The Development of New Ruthenium Catalyzed Reactions and a New Strategy for Cyclopentenone Synthesis PDF Download
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Author: Anthony Bruce Pinkerton
Publisher:
ISBN:
Category :
Languages : en
Pages : 954
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Author: Anthony Bruce Pinkerton
Publisher:
ISBN:
Category :
Languages : en
Pages : 954
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Author: Pierre H. Dixneuf
Publisher: Springer
ISBN: 3319084828
Category : Science
Languages : en
Pages : 404
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Book Description
The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics in pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors.
Author: Shun-Ichi Murahashi
Publisher: John Wiley & Sons
ISBN: 3527605797
Category : Science
Languages : en
Pages : 398
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In this comprehensive book, one of the leading experts, Shun-Ichi Murahashi, presents all the important facets of modern synthetic chemistry using Ruthenium, ranging from hydrogenation to metathesis. In 14 contributions, written by an international authorship, readers will find all the information they need about this fascinating and extraordinary chemistry. The result is a high quality information source and a indispensable reading for everyone working in organometallic chemistry. From the contents: Introduction (S.-I. Murahashi) Hydrogenation and Transfer Hydrogenation (M. Kitamura and R. Noyori) Oxidations (S.-I. Murahashi and N. Komiya) Carbon-Carbon Bond Formations via Ruthenacycle Intermediates (K. Itoh) Carbon-Carbon Bond Formation via pi-Allylruthenium Intermediates (T. Mitsudo) Olefin Metathesis (R. H. Grubbs) Cyclopropanation (H. Nishiyama) Nucleophilic Addition to Alkynes and Reactions via Vinylidene Intermediates (P. Dixneuf) Reactions via C-H Activation (N. Chatani) Lewis Acid Reactions (E. P. Kundig) Reactions with CO and CO2 (T. Mitsudo) Isomerization of Organic Substrates Catalyzed by Ruthenium Complexes (H. Suzuki) Radical Reactions (H. Nagashima) Bond Cleavage Reactions (S. Komiya)
Author: Ana Escribano Cuesta
Publisher: Springer Science & Business Media
ISBN: 3319007025
Category : Science
Languages : en
Pages : 202
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Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
![Investigations of [5+2] and Other Cycloadditions PDF](https://books.google.com/books/content/images/frontcover/aPWQAQAACAAJ?fife=w80-h100)
Author: Lauren Elizabeth Sirois
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Those who study new reactions and their selectivities are often driven by an interest in developing novel, practical methods that can be exploited to achieve complex chemical transformations over a small number of synthetic steps. The ultimate goal of such efforts is to achieve step economy, an overarching principle of green chemistry that minimizes reagents, waste, and production time. The design and application of metal-catalyzed and light-mediated cycloadditions is one important avenue of research, as such transformations can be atom economical and, more importantly, can create multiple bonds, rings, and stereocenters in a single step toward targets of high complexity and value. Linked to the development of new reactions is the design and understanding of new catalysts and ligands possessing novel reactivities and selectivities. Step economy can also be achieved by the clever streamlining of multiple transformations into a single synthetic operation, thus further reducing material and personnel costs. Such single-flask serial/cascade reactions can be used for the rapid assembly of molecular scaffolds, some of which comprise the core of targets with exciting physical properties or biological activity. The research presented in this dissertation addresses all of these themes. Within the context of similar reactions of activated, strained rings, Chapter 1 introduces the metal-catalyzed [5+2] cycloaddition of vinylcyclopropanes (VCPs) and pi-systems for the construction of seven-membered rings, an important motif in many natural products and natural-product-inspired synthetic targets. Chapter 2 describes the latest advancements in new catalysts and new ligands for the strategically convergent and operationally simple rhodium(I)-catalyzed intermolecular [5+2] reactions of VCPs and alkyne feedstocks. In Chapter 3, the regioselectivity of intermolecular [5+2] cycloadditions is explored systematically, as unsymmetrical substrates can give rise to multiple regioisomeric cycloadducts depending upon the orientation of the alkyne during a postulated (turnover-limiting) migratory insertion mechanistic step. Chapters 4 and 5 illustrate the development and application of single-flask / serial reactions involving the [5+2] cycloaddition, making use of the catalysts and insights from Chapters 2 and 3. In Chapter 4, an intermolecular [5+2] cycloaddition of enynones and VCPs, followed by a Nazarov cyclization, is envisioned for strategically novel and rapid access to the bicyclo[5.3.0]decane skeleton from readily available components. Chapter 5 describes the evolution of a project that, guided by the principles of function-oriented synthesis to access the minimally necessary chemical space for function via the fewest synthetic steps, uses serial [5+2]/[4+2] cycloadditions to assemble novel, potent inhibitors of protein kinase C (PKC). Lastly, Chapter 6 describes a total synthesis of penifulvin A, a sesquiterpenoid metabolite reported as the first example of a naturally occurring dioxa[5,5,5,6]fenestrane. The synthetic strategy features the use of an arene-alkene meta photocycloaddition as the key complexity-generating reaction.
Author: Lukas J. Gooßen
Publisher: Springer
ISBN: 3642342868
Category : Science
Languages : en
Pages : 345
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Barry Trost: Transition metal catalyzed allylic alkylation.- Jeffrey W. Bode: Reinventing Amide Bond Formation.- Naoto Chatani and Mamoru Tobisu: Catalytic Transformations Involving the Cleavage of C-OMe Bonds.- Gregory L. Beutner and Scott E. Denmark: The Interplay of Invention, Observation and Discovery in the Development of Lewis Base Activation of Lewis Acids for Catalytic Enantioselective Synthesis.- David R. Stuart and Keith Fagnou: The Discovery and Development of a Palladium(II)-Catalyzed Oxidative Cross-Coupling of Two Unactivated Arenes.- Lukas Gooßen and Käthe Gooßen: Decarboxylative Cross-Coupling Reactions.- A. Stephen K. Hashmi: Gold-Catalyzed Organic Reactions.- Ben List: Developing Catalytic Asymmetric Acetalizations.- Steven M. Bischof, Brian G. Hashiguchi, Michael M. Konnick, and Roy A. Periana: The De NovoDesign of CH Bond Hydroxylation Catalysts.- Benoit Cardinal-David, Karl A. Scheidt: Carbene Catalysis: Beyond the Benzoin and Stetter Reactions.- Kenso Soai and Tsuneomi Kawasaki: Asymmetric autocatalysis of pyrimidyl alkanol.- Douglas C. Behenna and Brian M. Stoltz: Natural Products as Inspiration for Reaction Development: Catalytic Enantioselective Decarboxylative Reactions of Prochiral Enolate Equivalents. Hisashi Yamamoto: Acid Catalysis in Organic Synthesis.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 180
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Author: Stanford University
Publisher:
ISBN:
Category :
Languages : en
Pages : 247
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Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 946
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Author: Montserrat Diéguez
Publisher: John Wiley & Sons
ISBN: 3527804072
Category : Technology & Engineering
Languages : en
Pages : 431
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Book Description
An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
