Author: Fargol Taba
Publisher:
ISBN:
Category : Photochemotherapy
Languages : en
Pages : 488

Get Book Here

Book Description

Author: Kathryn Wynne Woodburn
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 334

Get Book Here

Book Description

Author: Ravindra K Pandey
Publisher: World Scientific
ISBN: 9814719668
Category : Science
Languages : en
Pages : 563

Get Book Here

Book Description
The main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a 'product' from the bench to bed-side is also discussed.To have a clear concept of drug development the book is divided in three parts — Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.

Author: Todd Simard
Publisher:
ISBN:
Category :
Languages : en
Pages : 92

Get Book Here

Book Description

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

Get Book Here

Book Description

Author: Alexandra M. P. Santana Sorensen
Publisher:
ISBN:
Category :
Languages : en
Pages :

Get Book Here

Book Description

Author: Corey E. Stilts
Publisher:
ISBN:
Category :
Languages : en
Pages : 262

Get Book Here

Book Description

Author: Joseph Earl Bradshaw
Publisher:
ISBN:
Category :
Languages : en
Pages :

Get Book Here

Book Description
Photodynamic therapy (PDT) agents are light-activated materials used for localized disease treatment. Porphyrins are classic representations of photosensitive agents. Identified by their large, planar molecular structure, porphyrins are centrally composed of four pyrrole rings. Through this project, the starting material, H2TPPC, a tetra-carboxylic acid porphyrin, was first synthesized and later modified through the addition of the amine, morpholin-2-ylmethanol. This multi-step synthesis resulted in the highly water-soluble porphyrin product H2TPP-MorphMeOH. Following this synthesis, the compound was purified using liquid chromatography, and then structurally identified and classified using infrared (IR), nuclear magnetic resonance (NMR), and UV-Vis spectroscopies. Lastly, to determine its utility as a potential PDT agent, the cytotoxicity of H2TPP-MorphMeOH was determined using an MTT assay on MDA-MB-231 triple negative breast cancer cells comparing exposure and absence of white light.

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1398

Get Book Here

Book Description

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1064

Get Book Here

Book Description