The Assignment of the Absolute Configuration by NMR Using Chiral Derivatizing Agents PDF Download
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Author: José Manuel Seco
Publisher: Oxford University Press, USA
ISBN: 0199996806
Category : Science
Languages : en
Pages : 265
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Book Description
Nuclear magnetic resonance spectroscopy (NMR) is a technique that uses the magnetic properties of atomic nuclei to obtain information about the structure and properties of molecules. Proton and Carbon NMR, focusing on 1H and 13C, constitute the most powerful spectroscopic method for structure determination of Organic molecules. Application of this methodology to the assignment of absolute configuration was initiated in the late sixties and now is a well-established method that allows the rapid determination of the absolute configuration of more than one dozen different classes of mono-, bi-, and trifunctional organic compounds. Its simplicity requires the derivatization of the compound with a chiral arylalkoxyacetic acid, and examination of their 1H- and/or 13C-NMR spectra. In The Assignment of the Absolute Configuration by NMR using Chiral Derivatizing Agents: A Practical Guide, Professor Ricardo Riguera and coauthors organize this cutting-edge NMR research, offering a short and usable guide that introduces the reader to the research with a plethora of details and examples. The book briefly explains the theoretical aspects behind this methodology, dedicating most of its space to covering the practical aspects of the assignment, as well as the selection of the most adequate auxiliary reagent and the single or double derivatization, the use of resins etc. Examples and spectra taken from the authors' own experiments are included to illustrate the methodology. Upper-level undergraduates, graduate students, and chemical and pharmaceutical researchers will find this guide useful for their studies.
Author: José Manuel Seco
Publisher: Oxford University Press, USA
ISBN: 0199996806
Category : Science
Languages : en
Pages : 265
Get Book Here
Book Description
Nuclear magnetic resonance spectroscopy (NMR) is a technique that uses the magnetic properties of atomic nuclei to obtain information about the structure and properties of molecules. Proton and Carbon NMR, focusing on 1H and 13C, constitute the most powerful spectroscopic method for structure determination of Organic molecules. Application of this methodology to the assignment of absolute configuration was initiated in the late sixties and now is a well-established method that allows the rapid determination of the absolute configuration of more than one dozen different classes of mono-, bi-, and trifunctional organic compounds. Its simplicity requires the derivatization of the compound with a chiral arylalkoxyacetic acid, and examination of their 1H- and/or 13C-NMR spectra. In The Assignment of the Absolute Configuration by NMR using Chiral Derivatizing Agents: A Practical Guide, Professor Ricardo Riguera and coauthors organize this cutting-edge NMR research, offering a short and usable guide that introduces the reader to the research with a plethora of details and examples. The book briefly explains the theoretical aspects behind this methodology, dedicating most of its space to covering the practical aspects of the assignment, as well as the selection of the most adequate auxiliary reagent and the single or double derivatization, the use of resins etc. Examples and spectra taken from the authors' own experiments are included to illustrate the methodology. Upper-level undergraduates, graduate students, and chemical and pharmaceutical researchers will find this guide useful for their studies.
Author: José M. Seco
Publisher: Oxford University Press
ISBN: 0190463880
Category : Science
Languages : en
Pages : 264
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Book Description
Nuclear magnetic resonance spectroscopy (NMR spectroscopy) is a research technique that uses the magnetic properties of atomic nuclei to determine physical and chemical properties of atoms or the molecules in which they are contained. Proton NMR (1H NMR) is a technique that applies NMR spectroscopy specifically to the hydrogen-1 nuclei within the molecules of a substance, in order to determine the structure of that substance's molecules. The use of 1H NMR for the assignment of absolute configuration of organic compounds is a well-established technique. Recent research describes the technique's application to mono-, bi- and trifunctional compounds. In addition, several new auxiliary reagents, mono- and biderivatization procedures, on-resin methodologies and more recently, the use of 13C NMR, have been introduced to the field. In The Assignment of the Absolute Configuration by NMR Using Chiral Derivatizing Agents: A Practical Guide, eminent Professor of Organic Chemistry Ricardo Riguera organizes this cutting-edge NMR research. Professor Riguera offers a short and usable guide that introduces the reader to the research with a plethora of details and examples. The book briefly explains the theoretical aspects necessary for understanding the methodology, dedicating most of its space to covering the practical aspects of the assignment, with examples and spectra taken from the authors' own experiments. Upper-level undergraduates, graduate students, and chemical researchers will find this guide useful for their studies and practice.
Author: Thomas J. Wenzel
Publisher: John Wiley & Sons
ISBN: 1119324777
Category : Science
Languages : en
Pages : 1303
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Book Description
An updated guide to the most current information available for determining how to use NMR spectroscopy to differentiate chiral compounds Differentiation of Chiral Compounds Using NMR Spectroscopy offers a thoroughly revised second edition to the essential volume that puts the focus on the chiral systems that are commercially available and have been widely vetted for use in NMR spectroscopy. The text covers a broad range of reagents that make it possible to determine the enantiomeric purity and assign the absolute configuration of many classes of compounds. Comprehensive in scope, the text describes the chiral NMR differentiating agents as derivatizing agents, solvating agents, metal-based reagents and liquid crystals and gels, and explains the range and types of compounds for which they can be used for analysis. New to this edition are the most recent findings in the field as well as the development of advanced NMR measurement techniques that allow for the simplification of complex spectra resulting in more readily identified enantiodifferentiation. This important resource: Includes the most recent coverage of a large range of compounds that can be analyzed using chiral NMR reagents Explores the use of chiral NMR reagents and explains their relationship to the stereochemistry of the analyzed molecules Offers the essential information needed to help decide which method is the best NMR method to apply to a class or molecules Contains experimental strategies for using the reagents that are likely to improve the quality of the results Differentiation of Chiral Compounds Using NMR Spectroscopy is a comprehensive guide designed for investigators planning to use NMR spectroscopy to determine enantiomeric purity or assign the absolute configuration of a compound.
Author: Prasad L. Polavarapu
Publisher: CRC Press
ISBN: 1315357194
Category : Science
Languages : en
Pages : 298
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Book Description
This book details chiroptical spectroscopic methods: electronic circular dichroism (ECD), optical rotatory dispersion (ORD), vibrational circular dichroism (VCD), and vibrational Raman optical activity (VROA). For each technique, the text presents experimental methods for measurements and theoretical methods for analyzing the experimental data. It also includes a set of experiments that can be adopted for undergraduate teaching laboratories. Each chapter is written in an easy-to-follow format for novice readers, with necessary theoretical formalism in appendices for advanced readers.
Author: Piotr Garbacz
Publisher: Royal Society of Chemistry
ISBN: 1839169591
Category : Science
Languages : en
Pages : 268
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Book Description
How can we study one of the most elusive molecular properties, chirality, using nuclear interactions with the magnetic field that are apparently insensitive to handedness? This book answers this question from the physicochemical point of view by providing a clear, coherent, and comprehensive review of methods used in NMR studies of chirality. Presented arguments based on fundamental physical and chemical laws and in-depth descriptions of new methods utilizing purely physical interactions are mainly addressed to spectroscopists in both academia and industry. The introductory chapters provide the reader with the basics of NMR spectroscopy as a tool for the study of chiral compounds, and those more interested in the methods of chiral discrimination will benefit from the brief description of their common points and reasons why some of them may or may not work. In the following chapters, the book shows rapid progress in a newly emerging field of chirality-sensitive NMR, in particular, a search for effects that give direct information about the absolute configuration of a molecule.
Author: T. Claridge
Publisher: Elsevier
ISBN: 9780080427997
Category : Science
Languages : en
Pages : 408
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Book Description
From the initial observation of proton magnetic resonance in water and in paraffin, the discipline of nuclear magnetic resonance has seen unparalleled growth as an analytical method. Modern NMR spectroscopy is a highly developed, yet still evolving, subject which finds application in chemistry, biology, medicine, materials science and geology. In this book, emphasis is on the more recently developed methods of solution-state NMR applicable to chemical research, which are chosen for their wide applicability and robustness. These have, in many cases, already become established techniques in NMR laboratories, in both academic and industrial establishments. A considerable amount of information and guidance is given on the implementation and execution of the techniques described in this book.
Author: Maria-Magdalena Cid
Publisher: John Wiley & Sons
ISBN: 3527664637
Category : Science
Languages : en
Pages : 554
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Book Description
Intended for advanced readers, this is a review of all relevant techniques for structure analysis in one handy volume. As such, it provides the latest knowledge on spectroscopic and related techniques for chemical structure analysis, such as NMR, optical spectroscopy, mass spectrometry and X-ray crystallography, including the scope and limitation of each method. As a result, readers not only become acquainted with the techniques, but also the advantages of the synergy between them. This enables them to choose the correct analytical method for each problem, saving both time and resources. Special emphasis is placed on NMR and its application to absolute configuration determination and the analysis of molecular interactions. Adopting a practical point of view, the author team from academia and industry guarantees both solid methodology and applications essential for structure determination, equipping experts as well as newcomers with the tools to solve any structural problem.
Author: Oleg I. Kolodiazhnyi
Publisher: John Wiley & Sons
ISBN: 3527341536
Category : Science
Languages : en
Pages : 539
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Book Description
Authored by one of the leading experts in the field, this is the only comprehensive overview of chiral organophosphorus compounds, from asymmetric synthesis to catalysis and pharmacological applications. As such, this unique reference covers the chemical background as well as spectroscopical analysis of phosphorus compounds, and thoroughly describes all the various synthetic strategies for these substances. Metal-, organo- and biocatalyzed reactions for the introduction of phosphorus are explained as are asymmetric oxidation and reduction methods for the preparation of all possible oxidation states of phosphorus. The text also includes industrial applications for these compounds. Of particular interest to chemists working in the field of asymmetric synthesis, as well as to the pharmaceutical industry due to the increasing number of phosphorous-containing drugs.
Author: Ahindra Nag
Publisher: CRC Press
ISBN: 1315302292
Category : Medical
Languages : en
Pages : 665
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Book Description
This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds.
Author: Thomas J. Wenzel
Publisher: John Wiley & Sons
ISBN: 0471763527
Category : Science
Languages : en
Pages : 576
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Book Description
A comprehensive overview of the use of NMR spectroscopy for chiral discrimination Discrimination of Chiral Compounds Using NMR Spectroscopy concisely covers the broad array of reagents that make it possible to determine the optical purity and assign the absolute configuration of many classes of compounds. It describes chiral NMR derivatizing agents, solvating agents, metal-based reagents, and liquid crystals and discusses the range and types of compounds for which they can be used for analysis. After an overview of chiral reagents and methodologies, this reference: * Includes comprehensive coverage of the chiral reagents that have been reported * Catalogs the range of compounds for which different reagents have been shown to be effective * Includes specialty categories such as liquid crystals, ionic liquids, and the formation of chiral aggregates from achiral building blocks that do not fit into the broader categories * Offers experimental strategies for using the reagents that are likely to improve the quality of the results This guide describes the various systems and their overall utility, but goes further to show the full scope of the field as a way of guiding investigations into the optimal chiral reagents for use in NMR spectroscopy. It's a practical reference for organic chemists in the pharmaceutical industry, academia, and other areas, NMR spectroscopists, and researchers involved in the isolation and structure determination of natural products.
