Targeting Myeloid Cells to Fight Cancer PDF Download
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Author: Maija Hollmén
Publisher: Frontiers Media SA
ISBN: 2889633934
Category :
Languages : en
Pages : 150
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Book Description
Author: Maija Hollmén
Publisher: Frontiers Media SA
ISBN: 2889633934
Category :
Languages : en
Pages : 150
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Book Description
Author: Saul J. Priceman
Publisher: Elsevier Inc. Chapters
ISBN: 0128059222
Category : Medical
Languages : en
Pages : 33
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Book Description
Tumor-associated immune cells, in particular myeloid cells, have opposing roles during cancer development by facilitating antitumor immune responses and driving cancer-promoting inflammation. Defective antitumor immunity is prevalent in cancers, and it is now clear that overcoming the myeloid cell-mediated immunosuppressive microenvironment poses tremendous interest for future cancer therapies. JAK/STAT signaling has come to the forefront as a crucial pathway to induce immunosuppression and procancer inflammation. Specifically, STAT3 activation is critical for the phenotype of myeloid cells by regulating immunosuppressive and prometastatic factors, thereby providing myeloid cells with a multitude of tumor-promoting functions. Genetic ablation of STAT3 in the myeloid compartment induces potent innate and adaptive antitumor immunity along with an inhibition of tumor growth and metastasis. Recently, therapeutic targeting of JAK/STAT3 has shown great promise in blocking immunosuppression in preclinical models. One such example is the use of novel siRNA to selectively target STAT3 in myeloid cells, through conjugation to CpG oligonucleotides that agonize Toll receptor TLR9 on myeloid cells. Along with other novel therapeutic strategies to inhibit JAK/STAT signaling, it seems likely that future efforts to target this pathway will be made in single and combination approaches for effective anticancer immunotherapy.
Author: Sergei Kusmartsev
Publisher: Frontiers Media SA
ISBN: 2889714985
Category : Medical
Languages : en
Pages : 202
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Book Description
Author: David Escors
Publisher: Springer
ISBN: 331926821X
Category : Medical
Languages : en
Pages : 109
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Book Description
The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.
Author: Salem Chouaib
Publisher: Frontiers Media SA
ISBN: 2889638170
Category :
Languages : en
Pages : 196
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Book Description
Author: Brooke N. Benner
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 149
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Book Description
Author: Erik Wennerberg
Publisher: Frontiers Media SA
ISBN: 2889712710
Category : Medical
Languages : en
Pages : 144
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Book Description
Author: Andrew Robert Stiff
Publisher:
ISBN:
Category : Immune system
Languages : en
Pages :
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Book Description
While some of the mechanisms that cause impaired NK cell and T cell function are linked to processes inherent to tumor cells such as cytokine production and metabolic alterations it is also clear that cancer is linked to the expansion of multiple immune suppressive cell populations such as regulatory T cells (Treg), tumor associated macrophages (TAMs), and myeloid derived suppressor cells (MDSC).
Author: Erika Adriana Eksioglu
Publisher: Frontiers Media SA
ISBN: 2832541496
Category : Medical
Languages : en
Pages : 131
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Book Description
Author: Ali Syed Arbab
Publisher: Academic Press
ISBN: 0128232765
Category : Science
Languages : en
Pages : 204
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Book Description
New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. This book helps readers rethink treatment strategies to successfully fight glioblastomas. It is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field. Explains the effect of bone marrow derived cells on the development of resistance to clinically practiced therapies Provides information on the availability of alternate therapies for recurrent glioblastoma when standard practices have failed Discusses targeting tumor microenvironment using available FDA approved drugs as an alternative treatment strategy for glioblastoma
