T-Cell Paradigms in Parasitic and Bacterial Infections PDF Download
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Author: Stefan H.E. Kaufmann
Publisher: Springer Science & Business Media
ISBN: 3642749836
Category : Medical
Languages : en
Pages : 162
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Book Description
It has been said that the development of vaccines against a variety of infectious diseases is among the greatest triumphs of immunology. Indeed, several pathogens have lost their horror through the availability of effective vaccination measures. Unfortunately, this does not hold true for the pathogens dealt within this volume. Malaria, schistosomiasis, leishmaniasis, leprosy, and tuberculosis together are prevalent in more than 100 countries, and over 400 million persons suffer from these diseases. It is becoming increasingly clear that the failure to control these infections in a satisfactory way is directly related to the complexity oftheir interactions with the immune system. These agents have lived with their hosts for long enough to give both-host and parasite-ample opportunity to develop a highly sophisticated interrelationship. The central role of T lymphocytes both in acquired resistance to and pathogenesis of these microbes is well appreciated. In the beginning it may have been thought that acq uired resistance against infectious agents is nothing but another aspect of the immune response, studied with soluble and particulate antigens. This simple concept has gradually changed, and it has become clear that the viability not only of the immune cells but also of the 'antigens' adds another dimension to the game. Several achievements in cellular immunology and molecular biology have now made it possible to better understand at least some mechanisms in this intricate interplay.
Author: Stefan H.E. Kaufmann
Publisher: Springer Science & Business Media
ISBN: 3642749836
Category : Medical
Languages : en
Pages : 162
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Book Description
It has been said that the development of vaccines against a variety of infectious diseases is among the greatest triumphs of immunology. Indeed, several pathogens have lost their horror through the availability of effective vaccination measures. Unfortunately, this does not hold true for the pathogens dealt within this volume. Malaria, schistosomiasis, leishmaniasis, leprosy, and tuberculosis together are prevalent in more than 100 countries, and over 400 million persons suffer from these diseases. It is becoming increasingly clear that the failure to control these infections in a satisfactory way is directly related to the complexity oftheir interactions with the immune system. These agents have lived with their hosts for long enough to give both-host and parasite-ample opportunity to develop a highly sophisticated interrelationship. The central role of T lymphocytes both in acquired resistance to and pathogenesis of these microbes is well appreciated. In the beginning it may have been thought that acq uired resistance against infectious agents is nothing but another aspect of the immune response, studied with soluble and particulate antigens. This simple concept has gradually changed, and it has become clear that the viability not only of the immune cells but also of the 'antigens' adds another dimension to the game. Several achievements in cellular immunology and molecular biology have now made it possible to better understand at least some mechanisms in this intricate interplay.
Author: Michael B.A. Oldstone
Publisher: Springer Science & Business Media
ISBN: 3642785301
Category : Medical
Languages : en
Pages : 215
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Book Description
Cytotoxic T lymphocytes (CTL) control several viral infections in animals based on deletion and reconstitution experiments with CTL clones and use of CD8 genetically deficient (knock-out) mice. In this volume, data for the role that CTL play in human infectious diseases is presented. As such, this represents the first volume in which such information from several different viral and protozoan infections is brought together.
Author: Klaus Pfeffer
Publisher: Springer Science & Business Media
ISBN: 3642764924
Category : Medical
Languages : en
Pages : 277
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Book Description
Our current understanding of a/~ T cell receptor (TCR) ex pressing T cells advanced from function and specificity to the molecular organization ofthe TCR.We now know that the TCR a and ~ chains together express specificity for (antigenic) peptides presented by the "responder" M H C allele, thus explain ing the phenomenon of MHC restriction at a molecular level. Surprisingly even though our perception of the molecular organization of the y5 TCR is well advanced, current knowledge of function and specificity of the y5 T cell subset is poor. There fore it appeared rather timely to bring together scientists pioneering research on y5 T cells forthe International Workshop on Function and Specificity ofy5 Tcells,held October11-14, 1990 at Schloss Elmau/Bavaria, FRG. Besides offering a scientific forum for open discussions, it was also hoped that such a workshop would be seminal for collaborative interactions and personal relationships among scientists "addicted" to y 15 T cells.
Author: Dietrich Kraft
Publisher: CRC Press
ISBN: 9780849301360
Category : Medical
Languages : en
Pages : 358
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Book Description
Molecular Biology and Immunology of Allergens explores the characteristics of natural allergens and allergens produced by recombinant DNA techniques. The book covers important inhalant allergens such as pollen, mites, molds, and pet dander, as well as insect venoms and Chironomid hemoglobin allergens. Biological functions of allergens; the structural definition of allergens by NMR, crystallography, and computer modeling; and the production of recombinant allergens are discussed. Special attention is given to the search for the most effective expression systems in prokaryotic and eukaryotic organisms and the purification of recombinant allergens as fusion and non-fusion proteins. Other topics addressed include the production of allergen-specific T cell clones, the discovery of T cell epitopes by stimulation with overlapping peptides, and methods to induce T cell anergy by tolerogenic allergen-derived peptides. Molecular Biology and Immunology of Allergens will be an excellent reference for all researchers and clinicians in allergology, immunology, molecular biology, allergen extracting, and immunotherapy.
Author: Derek Wakelin
Publisher: Cambridge University Press
ISBN: 9780521436359
Category : Medical
Languages : en
Pages : 226
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Book Description
Parasites cause many important diseases in humans and domestic animals, malaria being an example. Parasites have evolved to exploit hosts' bodies whereas hosts have evolved immune systems to control infections. Host-parasite interactions therefore provide fascinating examples of evolutionary 'arms-races' in which the immune system plays a key role. Modern research in immunoparasitology is directed towards understanding and exploiting the capacity to develop effective anti-parasite immunity. By concentrating on selected infections where research has made significant progress, Immunity to Parasites provides a clear account of how host immune responses operate and how parasites can evade immunity. The experimental basis of this research is emphasised throughout. This completely updated second edition includes an expanded section on anti-parasite vaccines. The text is aimed at undergraduates and postgraduates with interests in either parasitology or immunology and provides introductory sections on these topics to lead the reader into the later chapters.
Author: C.H. Hagedorn
Publisher: Springer Science & Business Media
ISBN: 3642596053
Category : Medical
Languages : en
Pages : 386
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Book Description
Chronic hepatitis C is a major worldwide health problem affecting more than 170 million people. Chronic infections lead to cirrhosis and liver failure or hepatocellular cancer in many instances. This volume includes comprehensive reviews that cover much of the vast literature that has appeared since the identification of the hepatitis C virus RNA genome. It will be an invaluable collection for anyone wanting an up-to-date picture of HCV transmission, molecular virology, immune response, cellular/molecular pathogenesis, and possible avenues for developing effective new therapeutics and vaccines.
Author: Yogesh Dwivedi
Publisher: CRC Press
ISBN: 143983881X
Category : Medical
Languages : en
Pages : 485
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Book Description
With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
Author: James Swarbrick
Publisher: CRC Press
ISBN: 1439808236
Category : Medical
Languages : en
Pages : 880
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Book Description
Presenting authoritative and engaging articles on all aspects of drug development, dosage, manufacturing, and regulation, this Third Edition enables the pharmaceutical specialist and novice alike to keep abreast of developments in this rapidly evolving and highly competitive field. A dependable reference tool and constant companion for years to com
Author: David Schlossberg
Publisher: Springer Science & Business Media
ISBN: 1461383218
Category : Medical
Languages : en
Pages : 325
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Book Description
The gratifYing response to the first edition of Tuberculosis has prompted this revision. There are many important changes incorporated into this edition, including the dramatic effect of AIDS on the incidence and clinical mani festations of mycobacterial infection, new developments in epidemiology and bacteriology, and thoroughly updated therapeutic recommendations and principles of prophylaxis. The chapters that deal with clinical manifestations of tuberculosis have also been updated and include important and clinically applicable information on manifestations of tuberculosis in both the normal and immunocomprom ised host. As with the first edition, it is hoped that this text will continue to represent a definitive resource for both the basic scientist and the clinician who deal with the prevention and treatment of mycobacterial infection. II Preface to the First Edition We have just witnessed the lOOth anniversary of Koch's discovery of the tubercle bacillus. This event did not end the centuries-long saga of tuber culosis, however; it was but one major step in the ongoing struggle to un derstand and combat this disease. Tuberculosis is very much with us today, and its clinical manifestations and principles of treatment must be understood by both the primary care physician and the specialist. This monograph covers all aspects of tuberculosis in a single volume. It is divided into three parts, covering, respectively, general considerations, clin ical manifestations, and atypical mycobacterial infection.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1128
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Book Description
