Synthetic Polymer-protein Conjugates for Therapeutics PDF Download
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Author: Samantha B. McRae
Publisher:
ISBN:
Category : Lysozyne
Languages : en
Pages : 108
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Author: Samantha B. McRae
Publisher:
ISBN:
Category : Lysozyne
Languages : en
Pages : 108
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Author: Helmut Schlaad
Publisher: Springer
ISBN: 3642343503
Category : Technology & Engineering
Languages : en
Pages : 202
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Book Description
Polypeptide-Polymer Conjugates, by Henning Menzel Chemical Strategies for the Synthesis of Protein-Polymer Conjugates, by Björn Jung and Patrick Theato Glycopolymer Conjugates, by Ahmed M. Eissa and Neil R. Cameron DNA-Polymer Conjugates: From Synthesis, Through Complex Formation and Self-assembly to Applications, by Dawid Kedracki, Ilyès Safir, Nidhi Gour, Kien Xuan Ngo and Corinne Vebert-Nardin Synthesis of Terpene-Based Polymers, by Junpeng Zhao and Helmut Schlaad
Author: Johannes Martin
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
During the last decades, therapeutical proteins have risen to great significance in the pharmaceutical industry. As non-human proteins that are introduced into the human body cause a distinct immune system reaction that triggers their rapid clearance, most newly approved protein pharmaceuticals are shielded by modification with synthetic polymers to significantly improve their blood circulation time. All such clinically approved protein-polymer conjugates contain polyethylene glycol (PEG) and its conjugation is denoted as PEGylation. However, many patients develop anti-PEG antibodies which cause a rapid clearance of PEGylated molecules upon repeated administration. Therefore, the search for alternative polymers that can replace PEG in therapeutic applications has become important. In addition, although the blood circulation time is significantly prolonged, the therapeutic activity of some conjugates is decreased compared to the unmodified protein. The reason is that these conjugates are formed by the traditional conjugation method that addresses the protein's lysine side chains. [...].
Author: Gianfranco Pasut
Publisher: Elsevier
ISBN: 0444640827
Category : Technology & Engineering
Languages : en
Pages : 514
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Book Description
Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. - Provides an overview on the state-of-the-art of protein polymer conjugation - Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes - Outlines advantages and potential risks of present technology based on PEG - Offers new alternatives for PEG and new approaches for on site-selective protein modification - Identifies future direction of research in this field
Author: Greg T. Hermanson
Publisher: Academic Press
ISBN: 0080568726
Category : Science
Languages : en
Pages : 1233
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Book Description
Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions
Author: Jitender Madan
Publisher: Elsevier
ISBN: 0323916902
Category : Business & Economics
Languages : en
Pages : 510
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Book Description
Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ‘Linker Chemistry’ in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding. The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits. Covers mechanism, protocol and therapeutic significance of Polymer-Drug Conjugates Outlines updated methods and techniques to enumerate conjugation with related case studies Includes comprehensive compilation of marketed and clinical trial drugs conjugated with polymers or linkers
Author: Andrew Joseph McGahran
Publisher:
ISBN:
Category :
Languages : en
Pages : 55
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Book Description
In the first part of this thesis is described the use of free radical polymerization to synthesize a variety of sulfonated polymers. These polymers were employed in a biological screening study to determine their ability to participate in binding of basic fibroblast growth factor to its cellular receptor. Preliminary data suggests that poly(sodium vinyl sulfonate) (pVS) best serves this role. In order to obtain end-functionalized polymers with narrow molecular weight distribution profiles, controlled polymerizations of this monomer using reversible addition-fragmentation chain transfer (RAFT) were attempted. In addition, RAFT polymerization was used to synthesize poly(poly(ethylene glycol methyl ether acrylate)) (pPEGA) and poly(sodium styrene sulfonate)-co-poly(poly(ethylene glycol methacrylate)) (pSS-co-PEGMA). In the second part of this thesis, attempts to prepare fluorescent protein-polymer conjugates for use in biological mechanism studies are described. To achieve this, post-polymerization modification and fluorescent chain transfer agent (CTA) methodologies were employed to install a fluorescent tags onto these polymers.
Author: Greg T. Hermanson
Publisher: Elsevier
ISBN: 0080527906
Category : Medical
Languages : en
Pages : 813
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Book Description
Bioconjugate Techniques is the essential guide to the modification and crosslinking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Armed with this information and the abundant protocols provided, readers will form unique complexes that can be used for detecting, quantifying, and targeting important analytes. This book helps readers make: high activity antibody-enzymes conjugates, immunotoxins, immunogen complexes, liposome conjugates; as well as biotinylated molecules, avidin or streptavidin conjugates, colloidal gold labeled proteins, PEG or dextran complexes, labeled oligonucleotide probes, and fluorescently tagged or radiolabeled molecules. This book is the first to thoroughly capture the entire field of bioconjugate chemistry in a single volume Serves as a practical guide to modification and cross-linking technology for research, diagnostics, and therapeutics Provides useful, detailed, easy-to-follow, step-by-step protocols Contains easy-to-read, and easy-to-understand key concepts for making bioconjugates of all types Efficiently covers the chemistry of bioconjugation, the major reagents available for modification and cross-linking, and the application of these reagents to the synthesis of highly active conjugates Cites over more than references keyed to concepts covered in the book Uses more than 600 figures to illustrate bioconjugate reagents, their reactions, and applications Suggests sources for all key reagents
Author: Ronit Satchi-Fainaro
Publisher: Springer Science & Business Media
ISBN: 9783540292104
Category : Technology & Engineering
Languages : en
Pages : 224
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Book Description
Author: Thi H. Nguyen
Publisher:
ISBN:
Category :
Languages : en
Pages : 176
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Book Description
