Synthetic and Biosynthetic Approaches to Marine Natural Products PDF Download
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Author: Asunción Barbero
Publisher: MDPI
ISBN: 3039284665
Category : Medical
Languages : en
Pages : 182
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Book Description
Marine natural products containing a heterocyclic moiety in their structure are present in a wide variety of sponges, corals, algae, and fungi. Many of them show important biological activities such as cytotoxic properties against several cancer cell lines. Their challenging chemical structures have attracted the attention of many researchers who have developed various synthetic approaches. This Special Issue presents some examples of new synthetic or biosynthetic methodologies to access this type of marine natural drug.
Author: Asunción Barbero
Publisher: MDPI
ISBN: 3039284665
Category : Medical
Languages : en
Pages : 182
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Book Description
Marine natural products containing a heterocyclic moiety in their structure are present in a wide variety of sponges, corals, algae, and fungi. Many of them show important biological activities such as cytotoxic properties against several cancer cell lines. Their challenging chemical structures have attracted the attention of many researchers who have developed various synthetic approaches. This Special Issue presents some examples of new synthetic or biosynthetic methodologies to access this type of marine natural drug.
Author: Asunción Barbero
Publisher:
ISBN: 9783039284672
Category : Medicine (General)
Languages : en
Pages : 182
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Book Description
Marine natural products containing a heterocyclic moiety in their structure are present in a wide variety of sponges, corals, algae, and fungi. Many of them show important biological activities such as cytotoxic properties against several cancer cell lines. Their challenging chemical structures have attracted the attention of many researchers who have developed various synthetic approaches. This Special Issue presents some examples of new synthetic or biosynthetic methodologies to access this type of marine natural drug.
Author: Lawrence Evans Wolinsky
Publisher:
ISBN:
Category : Biosynthesis
Languages : en
Pages : 174
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Book Description
Author: Maria Costantini
Publisher: MDPI
ISBN: 3036502548
Category : Science
Languages : en
Pages : 92
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Book Description
In recent years, marine genomics has become a rapidly growing field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth’s surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs.
Author: Paul M. Dewick
Publisher: John Wiley & Sons
ISBN: 9780471496410
Category : Medical
Languages : en
Pages : 524
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Book Description
This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
Author: K.F. Albizati
Publisher: Springer Science & Business Media
ISBN: 3642768385
Category : Science
Languages : en
Pages : 334
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Book Description
Volumes five and six of Bioorganic Marine Chemistry differ from their predecessors in two respects - they deal exclusively with laboratory synthesis of marine natural products and they represent the effort of a single author and his associates. The rationale for these departures is readily perceived. For several decades organic synthesis has without doubt been the most spectacular branch of organic chemistry. While the late R.B. Woodward's dictum - organic compounds can undergo only four basic reactions: they can gain electrons; they can lose electrons; they can be transformed with acid or with base - is still true, the wealth and variety of available reagents which will accomplish chemical transformations has reached staggering proportions. Little wonder then, that synthetic methodology has achieved a high degree of predictability and total synthesis of natural products has been successfully directed toward ever more challenging targets. As for the second point, that of single authorship, multiple authorship would invariably have led to gaps and overlaps, thus making it difficult to assemble and assess recent research in a systematic and comprehens ive fashion.
Author: Paul J. Scheuer
Publisher: Springer
ISBN: 9783662149263
Category : Science
Languages : en
Pages : 185
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Book Description
Author: Hiromasa Kiyota
Publisher: Springer Nature
ISBN: 9811646376
Category : Science
Languages : en
Pages : 510
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Book Description
This book is a compilation of the latest achievements of leading researchers in marine natural products with extremely diverse structures and biological activities. It presents discussions of isolation, structure elucidation, biosynthesis, total synthesis, and biochemical properties of the compounds with characteristic structures such as macrolides, cyclic depsipeptides, alkaloids, and water-soluble heterocyclic low-molecular-weight compounds, from sponges, bacteria, cyanobacteria, flagellates, and other such organisms. The book especially focuses on heterocyclic natural products as a title in the book series, Topics in Heterocyclic Chemistry.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309169712
Category : Science
Languages : en
Pages : 130
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Book Description
Dramatic developments in understanding the fundamental underpinnings of life have provided exciting opportunities to make marine bioproducts an important part of the U.S. economy. Several marine based pharmaceuticals are under active commercial development, ecosystem health is high on the public's list of concerns, and aquaculture is providing an ever greater proportion of the seafood on our tables. Nevertheless, marine biotechnology has not yet caught the public's, or investor's, attention. Two workshops, held in October 1999 and November 2001 at the National Academies, were successful in highlighting new developments and opportunities in environmental and biomedical applications of marine biotechnology, and also in identifying factors that are impeding commercial exploitation of these products. This report includes a synthesis of the 2001 sessions addressing drug discovery and development, applications of genomics and proteomics to marine biotechnology, biomaterials and bioengineering, and public policy and essays contributed by the workshop speakers.
Author: K F Albizati
Publisher:
ISBN: 9783642768361
Category :
Languages : en
Pages : 296
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Book Description
This review is devoted to a compilation of the domain of na- tural product synthesis that involves metabolites from mari- ne organisms. The vast amountof material has been roughly organized along structural-biogenetic lines into two volu- mes: the first covers all terpenoid derived structures, the second nonterpenoid (amino acid, heterocyclic, fatty acid and other miscellaneous derived) metabolites. For each metabolite the source is discussed and some of the properties are described that make the compound attractive to synthesis chemists. These are mainly the substances' bio- logical, e.g. antitumor and antiviral activities.
