Synthesis of New Porphyrinoid Conjugates and Porphyrinoid Nanoparticles for Photodynamic Therapy Applicates PDF Download
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Author: Diana Samaroo
Publisher:
ISBN:
Category : Photochemotherapy
Languages : en
Pages : 406
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Author: Diana Samaroo
Publisher:
ISBN:
Category : Photochemotherapy
Languages : en
Pages : 406
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Book Description
Author: Roberto Paolesse
Publisher: Springer
ISBN: 3662439972
Category : Science
Languages : en
Pages : 184
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Book Description
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.
Author: Heinrich Lang
Publisher: Royal Society of Chemistry
ISBN: 1839164158
Category : Technology & Engineering
Languages : en
Pages : 374
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Book Description
Porphyrinoids are pyrrole-containing macrocycles with varied core sizes, which have found many applications beyond the original chemical and biological aspects. Porphyrin research has a long history, covering a wide variety of disciplines of natural sciences, including photosynthesis, P450-related biocatalysis, organic photovoltaic cells, photodynamic therapeutic agents, bioimaging probes, chemosensors, conductive organic materials, light-emitting materials, near-infrared dyes, nonlinear optical materials, information storage, molecular wires, and metal ligands. This book gives an overview of the applications and potential applications of porphyrins and related macrocycles as smart or functional materials. Chapters cover applications in fields such as energy storage and transfer, water purification, molecular electronics and imaging. With contributions from leading global researchers, this title will be of interest to graduate students and researchers across materials science, chemistry, physics and medicine.
Author: Ravindra K Pandey
Publisher: World Scientific
ISBN: 9814719668
Category : Science
Languages : en
Pages : 563
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Book Description
The main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a 'product' from the bench to bed-side is also discussed.To have a clear concept of drug development the book is divided in three parts — Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.
Author: Sarita Sitaula
Publisher:
ISBN:
Category : Photochemotherapy
Languages : en
Pages : 486
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Author: Katriann Arja
Publisher: Linköping University Electronic Press
ISBN: 9176852555
Category :
Languages : en
Pages : 105
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Book Description
Organic compounds that interact both with certain biological targets and display specific photophysical properties can be utilized as molecular tools to visualize and possibly effect disease related processes taking place in living organisms. In this regard, porphyrins are a class of naturally occurring molecules that possess intriguingly interesting photophysical properties where they can act as luminescent probes by emitting detectable light, as well as photosensitizers in the light mediated therapy called photodynamic therapy. In this thesis, the porphyrin structure has been synthetically combined with other molecule classes to achieve compounds with desirable multimodal characteristics. Firstly, luminescent conjugated oligothiophenes (LCOs) that have extensively, and with great success, been utilized as fluorescent ligands for amyloid formations, have been conjugated to porphyrins to render oligothiophene porphyrin hybrids (OTPHs) comprising two optically active modalities. When applied as fluorescent amyloidophilic dyes for visualization of amyloid-? (A?), one of the pathological hallmarks in Alzheimer’s disease, an enhanced optical assignment of distinct aggregated forms of A? was afforded. Thus, properly functionalized OTPHs could give us more information about pathological processes underlying devastating disorders, such as Alzheimer’s disease. In addition, the OTPHs can be associated with synthetic peptides inducing peptide folding into certain three-dimensional helical structures giving rise to novel optically active materials. Secondly, this thesis also embraces porphyrins’ potential as photosensitizers in photodynamic therapy to kill cancer cells. Grounded on the prerequisites for an optimal photosensitizer, we designed porphyrin-based conjugates equipped with common carbohydrates for improved cancer cell selectivity and with a fluorinated glucose derivative, 2-fluoro 2-deoxy glucose, for advantageous metabolism in cancer cells. Furthermore, incorporation of a radioisotopic fluorine-18 atom into the glycoporphyrins could give the means for diagnostic use of the conjugates in positron emission tomography (PET). In order to tether together the above-mentioned molecular moieties in a controlled fashion, we developed a robust synthetic strategy for asymmetrical functionalization of porphyrin core. The method involves chlorosulfonation of this otherwise inert tetrapyrrolic structure, followed by alkynylation. Parallelly to amide coupling reactions, copper(I)-catalyzed alkyne azide cycloaddition is used for fast and high-yielding late-stage conjugations. Overall, this thesis demonstrates how combining different molecular moieties in synthetic organic chemistry yields novel molecules with combined and improved multimodal properties for biological and medicinal applications, guided by the design-by-function methodology.
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 850
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Author: Roberto Paolesse
Publisher: Springer
ISBN: 3642385338
Category : Science
Languages : en
Pages : 301
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Book Description
The McMurry Reaction in Porphyrinoid Chemistry, by Kevin M. Smith Meso-tetraarylporphyrins: synthetic strategies and reactivity profiles based on nitro/amino substituents, by Maria da Graça Neves Functionalization of corroles, by José Cavaleiro Degradation pathways for porphyrinoids, by Jacek Wojaczynski Synthetic routes to porphyrinoids, by Sara Nardis Recent developments of non covalent porphyrin assemblies, by Donato Monti
Author: Homa Homayoni
Publisher:
ISBN:
Category : Afterglow (Physics)
Languages : en
Pages : 122
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Book Description
In Photodynamic therapy (PDT) PDT, cancer destruction relies on applying a photosensitizing drug (PS) followed by light. Absorbed light can activate the PS to transfer energy to existing molecules and substrates or to oxygen to generate singlet oxygen which are highly toxic to cells. Protophorphyrin IX (PpIX) is a photosensitizers (PSs) which has FDA approval and an absorbance near the Soret band which is 10 times stronger than the absorbance in Q-band (600nm). Our goal was to design a modality to eliminate of external blue light in addition to increasing the drug's water dispersion which finally may result in enhancing PDT efficiency. The hypothesis of this study proposes an enhanced PDT efficiency through the delivery of synthesized afterglow nanoparticles (AG NPs), which may be excited by both X-ray and UV and emit blue light for a long time, even after removing the energy source; Folic acid-PpIX-conjugated NPs could also improve the water dispersion of PpIX. Afterglow alkaline earth silicates (Sr3MgSi2O8) nanoparticles doped with rear earth elements (Eu, Dy) were synthesized through this study; the best parameters to achieve a successful synthesis were investigated. the silanol groups oriented outside of the AG NPs caused a net negative surface charge (- 38.52 mV). Alkaline wet grinding decreased the NP size from 809 ± 40.9 nm to 399.5 ± 117.5 nm. The surface silanization of synthesized AG NPs was induced to introduce an NH2 functional group on the surface of AG NPs for further drug and FA conjugation. After APTES coating, the surface charge changed to -4.28 mV because NH2 oriented out of the NPs surface. Adding a new layer caused size increments to 458 ± 136.8 nm. Calculations of Conjugation efficiency (CE) proved that 100 [microgram]/ml of APTES-coated AG NPs was containing of 43.043 ± 6.42 [microgram]/ml of APTES. Protonated PpIX dicholoride with high reactive COOH groups were successfully conjugated to the surface of APTES-AG NPs which led to better water dispersion of PpIX-AG NPs and caused 20 times enhancement of the red emission intensity of PpIX- AG NPs for the concentration equal to 6.25 [microgram]/ml of free PpIX compared to the same concentration of PpIX in water; in addition, 4 times concentration decrement of drug was observed to get most intense red emission. The results of the spectrofluorophotometer confirmed that FRET had happened between APTES-AG NPs and PpIX which corresponds to the successful conjugation of PpIX and NPs. The size decreased to 232 ± 1.3 nm. Raman spectroscopy results confirmed not only PpIX but also FA were successfully conjugated to APTES-AG NPs. Ultimate NPs (FA-PpIX-APTES-AG NPs) could improve the generation of singlet oxygen 2.4% more than free PpIX for concentration of 1.5 [microgram]/ml of free PpIX. Conjugation efficiency (CE) calculation showed that in 100 [microgram]/ml PpIX-APTES-AG NPs, there was a 2.050±0.207 [microgram]/ml of conjugated PpIX and 100 [microgram]/ml PpIX-APTES-AG NPs was containing 26.87±2.998 [microgram]/ml of FA. Exposed PC3 cells to ultimate NPs (equal to 5 [microgram]/ml of free PpIX) demonstrated 30% less dark toxicity and almost 15% more toxicity after exposure to UV for 5 min compared to that of free PpIX. All mentioned results proved that the fabrication of FA-PpIX-conjugated AG NPs may introduce an acceptable solution to current challenges of PDT including weak penetration of blue light and low water dispersion of PpIX in water.
Author: Francesca Bryden
Publisher:
ISBN:
Category :
Languages : en
Pages :
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