Synthesis of Internally Functionalized Silica Nanoparticles for Theranostic Applications

Synthesis of Internally Functionalized Silica Nanoparticles for Theranostic Applications PDF Author: Nathan Isaac Walton
Publisher:
ISBN:
Category : Nanoparticles
Languages : en
Pages : 100

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Synthesis of Internally Functionalized Silica Nanoparticles for Theranostic Applications

Synthesis of Internally Functionalized Silica Nanoparticles for Theranostic Applications PDF Author: Nathan Isaac Walton
Publisher:
ISBN:
Category : Nanoparticles
Languages : en
Pages : 100

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Mesoporous Silica Nanoparticles

Mesoporous Silica Nanoparticles PDF Author: Sachin Namdeo Kothawade
Publisher:
ISBN: 9783111338446
Category : Medical
Languages : en
Pages : 0

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Book Description
Mesoporous silica comprehensively covers the importance and applications of mesoporous silica nanoparticles in the field of nanoscience and nanotechnology. The book delves into the synthesis and characterization of mesoporous silica nanoparticles, discussing various synthesis methods and characterization techniques employed in their production. It explores the properties and structure of mesoporous silica nanoparticles, including their porosity, surface area, structural features, and tunability. It discusses mechanical, thermal, and optical properties. The applications of mesoporous silica nanoparticles in drug delivery are covered in detail, focusing on controlled release systems, targeted drug delivery, and theranostic applications.The catalytic applications of mesoporous silica nanoparticles are examined, including the use of these nanoparticles as supported catalysts in catalytic reactions, with discussions on reaction mechanisms. The book also explores the sensing and biosensing applications of mesoporous silica nanoparticles, including optical and electrochemical sensing, bioanalytical applications, and detection of biomolecules and environmental pollutants. Surface functionalization techniques for mesoporous silica nanoparticles are discussed, highlighting the importance of tailoring their properties for specific applications. Biocompatibility and toxicity considerations are addressed, providing insights into the assessment of biocompatibility, toxicity evaluation, mitigation strategies, and regulatory considerations. The future directions and emerging trends in mesoporous silica nanoparticle research are explored, along with interdisciplinary approaches, challenges, and opportunities in the field. The book concludes by summarizing the key findings and discussing the overall significance of mesoporous silica nanoparticles in nanoscience and nanotechnology. The references section provides a comprehensive list of sources used throughout the book for further exploration. The book serves as an essential resource for researchers, professionals, and students interested in understanding the synthesis, characterization, properties, and diverse applications of mesoporous silica nanoparticles in the realm of nanoscience and nanotechnology.

Synthesis of Phosphonate Functionalized Silica Nanoparticles for Protein Immobilization, Intracellular Protein Delivery and Catalytic Applications

Synthesis of Phosphonate Functionalized Silica Nanoparticles for Protein Immobilization, Intracellular Protein Delivery and Catalytic Applications PDF Author: Sai P. Maddala
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Silica-based Organic-inorganic Hybrid Nanomaterials

Silica-based Organic-inorganic Hybrid Nanomaterials PDF Author: Rakesh Kumar Sharma
Publisher: Wspc (Europe)
ISBN: 9781786347466
Category : Science
Languages : en
Pages : 0

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Book Description
Currently the field of nanocatalysis is undergoing many exciting developments and the design of silica-based organic-inorganic hybrid nanocatalysts is a key focus of the researchers working in this field. This book aims to present a succinct overview of the recent research progress directed towards the fabrication of silica-based organic-inorganic hybrid catalytic systems encompassing the key advantages of silica nanoparticles and silica-coated magnetic nanoparticles in an integrated manner. Featuring comprehensive descriptions of almost all approaches utilized for the synthesis of nanomaterials including some latest techniques such as flow and microwave-assisted synthesis that enable large-scale synthesis, it proves useful not only to academics but also industrialists. It also includes a systematic discussion on the vital characterization techniques employed for authenticating the structure of these. The title also offers an enormous amount of knowledge about the fusion of nanotechnology with green chemistry that strives to meet the scientific challenges of protecting human health and the environment.

Functionalization of Silica Micro-capillaries and Silica Nanoparticles Via Polymber Brushes

Functionalization of Silica Micro-capillaries and Silica Nanoparticles Via Polymber Brushes PDF Author: Andrew N. Constable
Publisher:
ISBN:
Category : Coatings
Languages : en
Pages : 169

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"Polymer brushes were synthesized on the interior of micro-capillaries to study the influence of brushes on solvent flow through a confined space. The synthesis of several polymer brush coatings was performed in fused silica micro-capillary tubing by atom transfer radical polymerization using the grafting from approach. Characterization of the polymer coatings inside of the capillaries was challenging due to inaccessibility of the sample geometry. Fluorescence spectroscopy was used as a technique to verify that covalently-attached polymer brushes were present. Capillary rise measurements demonstrated that the Zisman critical surface energy changes as the polymer coatings were modified from either a hydrophilic or a hydrophobic surface. The hydrophilic and hydrophobic nature of polymers leads to flow in micro-capillaries that can be manipulated and controlled in a passive fashion without external stimulus. Backpressure measurements were performed to show how selective solvents can be used to alter the backpressure required for flow. The measurements were used to correlate the flow of good/bad solvents with different polymer coatings; we speculate how these solvents alter brush conformation as an explanation for differentiated backpressure measurements. An analogous study involved capillaries functionalized with small molecule silanes which supported the hypothesis that the polymer brush is in an extended (solvated) state in good solvent and in a collapsed stated in bad solvent. Preferential flow experiments were designed to measure the preferred path an aqueous solvent would take when comparing two capillaries containing polymer coatings of different surface energies. Water flow preferred the hydrophilic, higher surface energy coated capillary when comparing capillaries of the same internal diameter. When the difference in internal size became too large, the surface energy effect was overwhelmed and the aqueous solvent flowed down the larger, hydrophobic capillary. The second portion of this dissertation describes the in situ formation of functionalized silica nanoparticles. The reactive stabilizers used in the study were (3-(2-bromoisobutyryl)propyl)triethoxysilane and (3-(2-bromoisobutyryl)propyl)ethoxy-dimethylsilane. Both stabilizers have an ATRP initiator at the non-condensable end yielding an initiator-immobilized silica nanoparticle. With the initiator-functionalized silica nanoparticles, ATRP synthesis was performed with styrene, tert-butyl acrylate and methyl acrylate. The size of these functionalized silica nanoparticles was controlled by varying the reactive stabilizer concentration and the time of addition. This work was extended by using preformed polymer chains as the reactive stabilizer. The polymer chain contained a monoethoxysilane-functional group which condensed to form hybrid polymer/silica nanoparticles. The relationships among the molecular weight, time of addition and concentration of the polymeric stabilizer to the nature of the resulting nanoparticle were studied. The large polymer reactive stabilizers did not afford the control in particle size observed with the small molecule reactive stabilizers."--Abstract.

Silica Nanoparticles

Silica Nanoparticles PDF Author: Juan Vivero-Escoto
Publisher:
ISBN: 9781613244524
Category : Biotechnology
Languages : en
Pages : 0

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Book Description
In this book, the authors present topical research in the study of the preparation, properties and use of silica nanoparticles. Topics discussed include the reactivity of inorganic radicals and excited triplet states in colloidal silica suspensions; multifunctional mesoporous silica nanoparticles for controlled drug delivery, multimodal imaging and simultaneous imaging and drug delivery; monodisperse luminescent silica nanoparticles and their application to DNA microarray technology.

Functionalized Silica Nanostructures

Functionalized Silica Nanostructures PDF Author: Yupeng Shi
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
Silica nanoparticles, thanks to the great easy and adaptability of particle synthesis and limited biotoxicity, is very widely studied for biomedical applications. This thesis conducted a large diversity of investigations involving silica nanomaterials. Firstly, the physicochemical properties and biodegradation properties of three types of structured silica nanoparticles were studied in a buffer, a culture medium and in contact with human dermal fibroblasts that suggest that, under these conditions, the silica nanoparticles must be mainly considered as degraded by hydrolysis and not biodegraded. Then, multifunctional silica nanoparticles which are consist of hollow silica nanoparticles and MnO2 nanosheets were synthesized. And the control drug release and imaging performance of this nanoplatforms were studied from 2D to 3D models. This approach could be used for a rapid assessment of the biofunctionality of nanoparticles before setting up in vivo experiments. Furthermore, a new 3D collagen-based nanocomposites using silica rods were studied and the relationships between the composite composition, structure and mechanical properties, emphasizing the key role of collagen-silica interactions. The influence of these parameters on the adhesion and proliferation of fibroblast cells was also investigated. In addition, we prepared and used magnetic silica nanorods to control particle orientation within the collagen network thanks to an external magnetic field. All the results bring new insights on the preparation and properties of bionanocomposites and open the route to multifunctional hydrogels.

FASTtrack Pharmaceutics

FASTtrack Pharmaceutics PDF Author: Yvonne Perrie
Publisher: Pharmaceutical Press
ISBN: 0857110594
Category : Medical
Languages : en
Pages : 257

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Book Description
"Pharmaceutics - Drug delivery and targeting focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs."--Page 4 of cover.

Nanotheranostics for Treatment and Diagnosis of Infectious Diseases

Nanotheranostics for Treatment and Diagnosis of Infectious Diseases PDF Author: Keerti Jain
Publisher: Academic Press
ISBN: 0323914691
Category : Medical
Languages : en
Pages : 414

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Book Description
Nanotheranostics for Treatment and Diagnosis of Infectious Diseases comprises the latest information on the technological advancements made in the field of nanotechnology for application in therapeutics with diagnostic applications. The book focuses on the theranostic applications of nanomaterials in infectious diseases, highlighting that rapid diagnosis, safe and effective treatment and strong preventive measures like vaccines are urgently needed. It compiles all relevant information to help scientists, researchers and students understand the role of nanomaterials, how nanomaterials could be explored simultaneously for therapeutic and diagnostic applications, and how to ensure safety and efficacy of these nanomaterials. Sections cover fundamental concepts, emerging concerns and challenges to combat infectious diseases, the characterization of nanomaterials for theranostic applications, and the toxicity, biocompatibility and regulatory perspectives in the diagnosis and treatment of infectious diseases. - Compiles the latest information on the technological advancements made in the field of nanotechnology for applications in therapeutics - Prepares researchers to get ready to fight any emergency which may arise due to the advent of infectious diseases - Focuses on the theranostic applications of nanomaterials in infectious diseases - Compiles all relevant information to help scientists, researchers and students in understanding the role of nanomaterials and how they could be explored for therapeutic and diagnostic applications

Synthesis and Properties of Substituted Polylactides and Surface Functionalization of Small Silica Nanoparticles

Synthesis and Properties of Substituted Polylactides and Surface Functionalization of Small Silica Nanoparticles PDF Author: Quanxuan Zhang
Publisher:
ISBN: 9781303339127
Category : Electronic dissertations
Languages : en
Pages : 271

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Book Description