Synthesis and Evaluation of Novel Heterocyclic Compounds as Anticancer Agents PDF Download
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Author: A. A. R. A. Mal ullah
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: A. A. R. A. Mal ullah
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Bimal Krishna Banik
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110735776
Category : Science
Languages : en
Pages : 532
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Book Description
Cancer is an incredibly diverse and difficult disease to treat, and even after decades of research there is no definitive cure. Therefore, it is highly crucial to search for novel and new organic molecules with high potency, low toxicity, and low mutagenicity with selective anticancer properties that are able to overcome frequently developed resistance to available drugs. Heterocyclic anticancer agents are an important class of drugs for cancer therapies. This book explores different heterocycles and their use as anticancer therapies. Topics covered include different heterocyclic derivatives, the impact of heterocycles on anticancer agent development, and naturally occurring heterocycles.
Author: Qiao-Hong Chen
Publisher: MDPI
ISBN: 3036501401
Category : Business & Economics
Languages : en
Pages : 606
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Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Author: Keshav Lalit Ameta
Publisher: Springer Nature
ISBN: 981190832X
Category : Science
Languages : en
Pages : 465
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Book Description
This book presents an overview of the recent advancements for the synthesis of small- and medium-sized azaheterocycles, including pyrroles, indoles, pyrimidines, pyridines, pyrrolidines, imidazoles, pyrazoles, pyrazolines, lactams, and 1,2,3-triazoles, which are significant scaffolds for compounds with pharmaceutical uses. The book also discusses various properties and performance attributes of azaheterocycles including their bioactivity and synthetic strategies. Given the contents, the book will be a valuable reference for students, researchers, and professionals interested in organic synthesis and medicinal chemistry.
Author:
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Category :
Languages : en
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Author: Pilar Munoz Ruiz
Publisher:
ISBN:
Category :
Languages : en
Pages : 426
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Author: Al-Ameen Abubakar Mohammed
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Category :
Languages : en
Pages :
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Author: Vikki Clark Pearson
Publisher:
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Category :
Languages : en
Pages : 165
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Author: Parag Rabara
Publisher:
ISBN: 9783659873072
Category :
Languages : en
Pages : 84
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Author: Jin Chen
Publisher:
ISBN: 9781109967388
Category : Antineoplastic agents
Languages : en
Pages : 373
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Book Description
A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.
