Studies Toward the Synthesis of Lyconadin A and Cranomycin PDF Download
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Author: Brad M. Loertscher
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 191
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Book Description
Lyconadin A is a pentacyclic Lycopodium alkaloid isolated from the club moss Lycopodium companatum with anticancer activity. Our approach sought to incorporate a 7-exo-6-exo acyl radical cyclization cascade to access the bicyclo[5.4.0]undecane framework of lycoadin A. Our studies created methodology for the synthesis of 5-alkyl and 3,5-dialkyl-6-carbomethoxy-2-pyridones and sterically demanding epoxide substrates. These epoxide substrates underwent an unanticipated Payne rearrangement.
Author: Brad M. Loertscher
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 191
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Book Description
Lyconadin A is a pentacyclic Lycopodium alkaloid isolated from the club moss Lycopodium companatum with anticancer activity. Our approach sought to incorporate a 7-exo-6-exo acyl radical cyclization cascade to access the bicyclo[5.4.0]undecane framework of lycoadin A. Our studies created methodology for the synthesis of 5-alkyl and 3,5-dialkyl-6-carbomethoxy-2-pyridones and sterically demanding epoxide substrates. These epoxide substrates underwent an unanticipated Payne rearrangement.
Author: Koudi Zhu
Publisher:
ISBN:
Category : Alkaloids
Languages : en
Pages : 74
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Book Description
Lyconadin A is an alkaloid possessing a unique structure and antitumor activity. The total synthesis of Lyconadin A was proposed via an acyl radical cascade reaction. To investigate the possibility and stereoselectivity of the cascade cyclization, phenyl selenoester 16 was chosen as a model substrate to study the 7-exo-5-exo radical cyclization. A synthetic route to phenyl selenoester 16 was developed. The 7-exo-5-exo radical cyclization was found to occur with a high yield and excellent stereoselectivty. Attempts were also tried to synthesize another radical precursor 14 albeit with less success. A synthetic pathway to the synthesis of 14 as well as its potential use in the context of the synthesis of Lyconadin A was proposed.
Author: Yu Zhang
Publisher:
ISBN:
Category :
Languages : en
Pages : 173
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Book Description
Lyconadin A is a pentacyclic Lycopodium alkaloid isolated from the club moss Lycopodium complanatum with antitumor properties. We have developed a novel 7-exo/6-exo acyl radical cascade cyclization as a method of making the bicyclo[5.4.0]undecane ring system of lyconadin A. The model products are trans-fused ring systems, while a cis-fused ring system is needed in lyconadin A. We have discovered a method to convert the trans-fused model cascade cyclization product into the desired cis isomer. Based on Donohoe's pyridone synthesis, we developed a method for the construction of 5-alkyl and 3,5-dialkyl-6-carbomethoxy-2-pyridones, the former of which is a subunit of lyconadin A. An intramolecular Reformatsky reaction is a key step in this process. We have proceeded with our total synthesis, in which we generated an epoxide by Shi asymmetric epoxidation and regioselectively opened epoxide rings. We have prepared carboxylic acid 197.
Author: David C. Morgan
Publisher: American Mathematical Soc.
ISBN: 1470436744
Category : Crafts & Hobbies
Languages : en
Pages : 154
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Book Description
When origami met the worlds of design and engineering, both fields embraced the ancient art form, using its principles and practices to discover new problems and to generate inventive solutions. This book demonstrates the potential of folding to improve the way things work, simplify how products are produced, and make possible new objects otherwise impossible. The solar collector, the felt stool, and the surgery tool have all been influenced in some way by folding paper. The example section is organized to show the folded figure next to the product prototype that was inspired by that work of origami. We have included models made from an array of materials over a range of sizes. This includes everything from a microscopic mechanism to huge solar panels designed to unfold in outer space. Most entries are at the prototype phase—meaning that physical hardware has been built to demonstrate the concept, but that the examples are not necessarily available commercially. Y Origami? also includes brief learning activities related to paper folding, such as a discussion of Euler's formula, angular measurements, and developable surfaces, along with more advanced topics. Throughout the book many diagrams and photographs illustrate the advancing concepts and methods of origami as an art form and a problem-solving strategy.
Author: Aravind Asthagiri
Publisher: Royal Society of Chemistry
ISBN: 1849734518
Category : Science
Languages : en
Pages : 277
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Book Description
This book presents a comprehensive review of the methods and approaches being adopted to push forward the boundaries of computational catalysis.
Author: William Angus Knight
Publisher: Edinburgh : W. Paterson
ISBN:
Category : Poets, English
Languages : en
Pages : 452
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Book Description
Author: Jiali Gao
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 328
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Book Description
Combined quantum mechanical and molecular mechanical methods (QM/MM) is one of the most promising approaches for quantum mechanical calculations of chemical processes in solution and in enzymes. This book provides an in-depth survey of the methods and applications of these combined techniques in chemistry and biochemistry.
Author: O.Henry
Publisher: Strelbytskyy Multimedia Publishing
ISBN:
Category : Fiction
Languages : en
Pages : 11
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Book Description
The story is about a wealthy businessman whose son wants to propose to his sweetheart before she leaves the USA for Europe in a couple of days’ time. Although the son believes that money cannot buy you time – the one thing he dearly needs more of if he is to woo his beloved – the events of the story suggest that money can be used to buy someone extra time. O. Henry's short stories are well known for their wit, wordplay, warm characterization and clever twist endings.
Author:
Publisher:
ISBN:
Category : Radiochemical analysis
Languages : en
Pages : 98
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Book Description
Author: John E. Clark
Publisher: New World Archaeological Foundation
ISBN: 9781949847413
Category : History
Languages : en
Pages : 0
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Book Description
Group B was one of the key architectural groups extensively excavated by NWAF in the early 1960s at the iconic Late Preclassic center of Izapa. The excavations, caches, burials, and stone monuments are presented in detail, as well as broader assessments of the site by Gareth W. Lowe and John E. Clark.
