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Author: Goutam Brahmachari
Publisher: Elsevier
ISBN: 0081028237
Category : Science
Languages : en
Pages : 352
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Book Description
Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. - Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules - Outlines each step of the process in detail, with full experimental information supported by extensive schemes - Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule
Author: Goutam Brahmachari
Publisher: Elsevier
ISBN: 0081028237
Category : Science
Languages : en
Pages : 352
Get Book Here
Book Description
Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. - Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules - Outlines each step of the process in detail, with full experimental information supported by extensive schemes - Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule
Author: Tao Wang
Publisher: Frontiers Media SA
ISBN: 2889660869
Category : Science
Languages : en
Pages : 99
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: Jie Jack Li
Publisher: Springer Science & Business Media
ISBN: 3642340652
Category : Science
Languages : en
Pages : 292
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Book Description
'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Author: Yiwen Zhang
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
The body of this thesis is comprised of four scientific journal articles and a patent. It is preceded by an overview that contextualizes all of this submitted/published work. The first major part of this thesis is comprised of Publication 1. This is a review concerned with the chemical syntheses of the cochliomycins, including congener A, and certain related resorcylic acid lactones (RALs). pecifically, Publication 1 reviews the recently published literature on the cochliomycins and related, co-occurring RALs and is accompanied by a brief commentary on the source organisms and certain of their biological properties. It serves to contextualize some of the author's other published research incorporated in the thesis. The second major part of this thesis is comprised of Publication 2. This details work concerned with establishing the true structure of the marine-derived RAL neocosmosin A. Specifically, the structure, A, originally assigned to neocosmosin A was synthesized with the key steps involving olefin-cross metathesis, ring-closing metathesis, palladium- catalyzed Meinwald rearrangement and Mitsunobu esterification reactions. A late-stage and simple modification to the reaction sequence also provided the enantiomer B that, in fact, represents the true structure of the natural product. The third major part of this thesis is comprised of Publication 3. This details the development of modular total syntheses of the marine-derived alkaloids discoipyrroles A and B. Specifically, the intermediates C and D (see below) were prepared from (parent) pyrrole using Ullmann-Goldberg and Suzuki-Miyaura cross-coupling, Vilsmeier-Haack formylation, electrophilic bromination, and Wittig olefination reactions as key steps. A late stage MoOPH-mediated oxidative cyclization reaction was then employed to assemble the novel heterobicyclic core of the target discoipyrroles. The fourth major part of this thesis is comprised of Publication 4. This details the first total synthesis of the most structurally complex member of the small family of marine- derived discoipyrroles, namely congener D. This synthesis, which used methodology developed during the course of the aforementioned syntheses of the discoipyrroles A and B, involved, as key steps, the MoOPH-mediated oxidative cyclization of precursor E and this was followed by conjugate addition and redox processes. The fifth and final part of this thesis is comprised of Publication 5. This patent details inventions related to methods for preparing a variety of discoipyrrole-like compounds and novel analogues, as well as pharmaceutical compositions comprising these compounds and their possible use in therapeutic settings. For example, compound F, which incorporates a discoipyrrole-like core structure, was synthesized in four steps from indole and involving the aforementioned MoOPH-mediated oxidative cyclization as one of the key processes. The Appendices to the thesis are comprised of a series of reports arising from single-crystal X-ray analyses of certain key compounds synthesized by the author. Drs Jas Ward, Paul Carr or Anthony Willis, members of the Research School of Chemistry's Crystallographic Analysis Unit, conducted these analyses.
Author: Sasadhar Majhi
Publisher: World Scientific
ISBN: 9811268703
Category : Science
Languages : en
Pages : 469
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Book Description
Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.
Author: Atta-ur Rahman
Publisher: Elsevier
ISBN: 0128179066
Category : Science
Languages : en
Pages : 460
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Book Description
Studies in Natural Products Chemistry: Bioactive Natural Products, Volume 65, the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, provides cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products. This has opened up exciting opportunities in the field of new drug development to the pharmaceutical industry. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores
Author: Spiros I. Liras
Publisher:
ISBN:
Category :
Languages : en
Pages : 268
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Book Description
Author:
Publisher: Elsevier
ISBN: 0444636102
Category : Science
Languages : en
Pages : 472
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Book Description
Studies in Natural Products Chemistry, Volume 48, provides the latest on the use of natural products from the plant and animal kingdom and the ways in which they can offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development. The series covers all aspects of the science, along with the synthesis, testing, and recording of the medicinal properties of natural products. With articles written by leading authorities in their respective fields of research, the book presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable resource for all those working in natural product and medicinal chemistry. - Provides the latest on the use of natural products from the plant and animal kingdom and the ways in which they can offer a huge diversity of chemical structures - Focuses on the chemistry of bioactive natural products and their exciting new applications in the pharmaceutical industry - Presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products - Contains contributions by leading authorities in the field
Author: Xiao-Tian Liang
Publisher: John Wiley & Sons
ISBN: 0471739332
Category : Science
Languages : en
Pages : 482
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Book Description
Current discoveries and research into bioactive natural products Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents. Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research. Enhanced by examples with updated research results, the discussion covers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and its analogs * The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer's disease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIV agents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and their structurally modified mimics
Author: Pei-Qiang Huang
Publisher: John Wiley & Sons
ISBN: 1118940202
Category : Science
Languages : en
Pages : 512
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Book Description
Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals
