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Author: V. Tarannu Aafiya S
Publisher: Independent Author
ISBN: 9781805307563
Category : Mathematics
Languages : en
Pages : 0
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Book Description
Ionic liquids have emerged as an innovative material for various applications due to their unique physicochemical properties. Collagen matrices have been used as a scaffold in tissue engineering and regenerative medicine due to their excellent biocompatibility and biodegradability. The combination of these two materials has attracted much attention in recent years. The studies on ionic liquids effect on collagen matrices have been carried out to investigate the potential applications of these materials. The effects of ionic liquids on collagen matrices have been studied in terms of their chemical modification, physical properties, mechanical properties, rheological properties, swelling behavior, gelation, and crosslinking. The ionic strength of the solution has been shown to play a crucial role in the properties of the collagen matrices. Cytotoxicity studies have been performed to evaluate the biocompatibility of these materials. In vitro and in vivo studies have been carried out to investigate the cell culture, cell proliferation, cell adhesion, cell differentiation, and extracellular matrix formation of the collagen-ionic liquid composite materials. The potential applications of these materials include wound healing, drug delivery, tissue engineering, and regenerative medicine. Electrospinning has been used to produce electrospun fibers and nanofiber scaffolds of collagen-ionic liquid composites for biomedical applications. The surface modification of these materials has also been studied to improve their properties for various biomedical applications. The studies on ionic liquids effect on collagen matrices have the potential to provide new insights into the development of novel materials for various biomedical applications. The chemical synthesis, analytical methods, and characterization of these materials are crucial to understanding the molecular interactions and interfacial phenomena that occur in these systems. The interdisciplinary field of polymer science, polymer chemistry, biophysics, and biomechanics is essential in advancing the development of collagen-ionic liquid composites for various biomedical applications.
Author: V. Tarannu Aafiya S
Publisher: Independent Author
ISBN: 9781805307563
Category : Mathematics
Languages : en
Pages : 0
Get Book Here
Book Description
Ionic liquids have emerged as an innovative material for various applications due to their unique physicochemical properties. Collagen matrices have been used as a scaffold in tissue engineering and regenerative medicine due to their excellent biocompatibility and biodegradability. The combination of these two materials has attracted much attention in recent years. The studies on ionic liquids effect on collagen matrices have been carried out to investigate the potential applications of these materials. The effects of ionic liquids on collagen matrices have been studied in terms of their chemical modification, physical properties, mechanical properties, rheological properties, swelling behavior, gelation, and crosslinking. The ionic strength of the solution has been shown to play a crucial role in the properties of the collagen matrices. Cytotoxicity studies have been performed to evaluate the biocompatibility of these materials. In vitro and in vivo studies have been carried out to investigate the cell culture, cell proliferation, cell adhesion, cell differentiation, and extracellular matrix formation of the collagen-ionic liquid composite materials. The potential applications of these materials include wound healing, drug delivery, tissue engineering, and regenerative medicine. Electrospinning has been used to produce electrospun fibers and nanofiber scaffolds of collagen-ionic liquid composites for biomedical applications. The surface modification of these materials has also been studied to improve their properties for various biomedical applications. The studies on ionic liquids effect on collagen matrices have the potential to provide new insights into the development of novel materials for various biomedical applications. The chemical synthesis, analytical methods, and characterization of these materials are crucial to understanding the molecular interactions and interfacial phenomena that occur in these systems. The interdisciplinary field of polymer science, polymer chemistry, biophysics, and biomechanics is essential in advancing the development of collagen-ionic liquid composites for various biomedical applications.
Author: Leah C. Abraham
Publisher:
ISBN:
Category : Biomedical engineering
Languages : en
Pages : 434
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Book Description
The structure and morphology of biomaterial matrices and the deposition of extracellular matrix (ECM) are interdependent issues critical to the integration of bioengineered materials and tissues in vivo. To address the mechanistic basis for the relationships between matrices and cells, a model system was studied in vitro employing type I collagen and human fibroblasts. We hypothesized that collagen structure influences rate and extent of matrix remodeling and deposition due to differences in surface chemistry and enzymatic digestion. To evaluate this hypothesis, matrix trafficking was assessed quantitatively and fit to a model by tracking collagen and proline metabolic fluxes. Human fibroblasts (IMR-90) were used to study the effect of collagen matrix structure variations on cell phenotypic and genotypic outcomes. Cell proliferation, morphology, senescence-specific beta-galactosidase, transcript content for Collagen-1, Matrix Metal loproteinase-1, Matrix Metal loproteinase-2, Tissue Inhibitor of Matrix Metal loproteinase-1, and Tissue Inhibitor of Matrix Metalloproteinase-2, trafficking of radio labeled collagen and proline from cell substrate or media, matrix phagocytosis, and intracellular protein levels were determined. The collagen matrices were characterized as functions of helicity, chemical composition, and topology. Cells grown on denatured collagen exhibited: improved cell viability, morphology and lower beta-galactosidase, senescence associated, activity; a significantly higher level of collagen matrix incorporation; and significantly greater levels of matrix remodeling (indicated by transcript levels) when compared to cells grown on native collagen and tissue culture plastic. The data suggest that denatured collagen promotes more active remodeling toward new extracellular matrix. This is significant because remodeling of tissue engineering matrices is critical to the integration of in vivo implants, and remodeling is integral to the pathology of several collagen related diseases. The ability to quantitatively address issues related to matrix trafficking offers a more systemic approach to understanding the influence of biomaterial structure, morphology, chemistry, or extracellular matrix features, on tissue remodeling, wound repair and disease progression. The model presents a quantitative basis for cell-matrix interactions and provides a critical first step toward future studies in which modes to influence these physiological features can be rationally assessed.
Author: Bin Xu
Publisher:
ISBN:
Category :
Languages : en
Pages : 266
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Book Description
Abstract: Collagen is the most abundant protein in the body. It plays critical roles in many supporting and connecting tissues. Collagen matrices prepared from commercially available collagen solution have been broadly used as a biomaterial in tissue engineering, drug delivery, and wound healing for its biocompatibility, low toxicity, and well-documented physical, chemical, and immunological properties. Collagen matrices are also used as three-dimensional model systems of extracellular matrix (ECM) in numerous studies of cell-ECM interactions under physiological and pathological conditions. As a biphasic material, collagen matrices contain a solid phase representing by collagen network and an interstitial fluid phase. This special structure makes collagen a viscoelastic material. The overall research goal of this thesis is to characterize the macroscopic elastic and viscoelastic properties of collagen matrices in both the frequency and time domain and to understand the deformation mechanisms using a coupled experimental and modeling approach. Hydrated collagen gel and dehydrated collagen thin film are exploited as two different hydration levels of collagen matrices. Genipin solution is used to induce crosslinking in collagen matrices.Biaxial tensile stress relaxation results show that the rate of stress relaxation of both hydrated and dehydrated collagen matrices shows a linear initial stress level dependency. Increased crosslinking reduces viscosity in collagen gel, but the effect is negligible for thin film. Relaxation time distribution spectrum was obtained from the stress relaxation data by inverse Laplace transform. For most of the collagen matrices, three peaks at the short (0.3s ∼ 1s), medium (3s ∼ 90s), and long relaxation time (>200s) were observed in the continuous spectrum, which corresponds with relaxation mechanisms involve fiber, inter-fibril, and fibril sliding. The intensity of the long-term peaks increases with higher initial stress levels indicates the engagement of collagen fibrils at higher levels of tissue strain. Splitting of the middle peak was observed at higher initial stress levels suggesting increased structural heterogeneity at the fibril level with mechanical loading. A viscoelastic constitutive model combining hyperelastic and generalized Maxwell model was established with viscous material parameters obtained directly from analysis of the relaxation time spectrum.Rheological shear relaxation and dynamic rheological tests were performed on collagen gel. Crossover of storage and loss modulus was observed from frequency sweep tests. The crossover frequency shows both strain amplitude and crosslinking dependency. Both dynamic moduli and shear relaxation modulus demonstrate strain-softening behavior. Conversion from frequency domain measurements to time domain properties was achieved through relaxation spectrum obtained by Tikhonov regularization method. The relaxation spectrum shows two obvious peaks between 0.01s∼0.1s and between 10s∼40s, which indicate the existence of fast and slow dominant relaxation processes. The peak between 0.01∼0.1s correspond is likely due to the collagen fiber-interstitial fluid sliding. In shear deformation both collagen fiber network and interstitial fluid play important roles, which contribute to the differences in relaxation mechanisms between rheological shear and tensile relaxation tests.
Author: Francesca D’Anna
Publisher: Frontiers Media SA
ISBN: 2889630056
Category :
Languages : en
Pages : 360
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Book Description
Sustainability, defined as the way to meet the needs of the present generation without compromising the ability of future ones to meet their own, is one of the main challenges of modern society. Within this context, chemistry plays a significant role, and solvent nature as well as its environmental impact are pivotal issues frequently addressed. Ionic liquids, i.e. organic salts that have melting temperatures lower than 100 °C, have been frequently hailed as alternatives to conventional organic solvents. Their greenness has been mainly ascribed to their low vapor pressure and flammability. However, in addition to this, their high solubilizing ability and low miscibility with conventional organic solvents frequently allow for reducing the amount used, as well as for their recycling. Ionic liquids, especially the ones featured by aromatic cations, are frequently described as “polymeric supramolecular fluids” constructed through the establishment of feeble but cooperative supramolecular interactions like Coulomb and π-π interactions, as well as hydrogen bonds. In general, ionic liquids are also indicated as “designer solvents” as it is possible to tailor their features to specific applications by simply modifying their cation or anion structure. In this way, small changes in the ion’s structure can give rise to solvents showing very different properties. The above premises widely justify the growing interest in the properties and applications of ionic liquids, seen in recent literature (according to Scopus, more than 27,000 papers published in the last five years have “ionic liquids” as a keyword). Thanks to their properties, they have been variously used as solvent media, solvents for the obtainment of gel phases, components in the building of dye-sensitized solar cells, media for the preparation of thermochromic materials, etc. This Research Topic aims to present how structural features can determine not only the properties of ionic liquids, but also their possible employment. In this latter case, the interest arises from their ability to affect the outcome of a given reaction in terms of rate, yield, and nature of the products obtained for general use in the field of materials chemistry. This article collection is dedicated to Prof. Kenneth R. Seddon for his outstanding contribution to the formation and development of the ionic liquids community.
Author: Bidyut K. Paul
Publisher: John Wiley & Sons
ISBN: 1118834194
Category : Science
Languages : en
Pages : 578
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Book Description
This volume will be summarized on the basis of the topics of Ionic Liquids in the form of chapters and sections. It would be emphasized on the synthesis of ILs of different types, and stabilization of amphiphilic self-assemblies in conventional and newly developed ILs to reveal formulation, physicochemical properties, microstructures, internal dynamics, thermodynamics as well as new possible applications. It covers: Topics of ionic liquid assisted micelles and microemulsions in relation to their fundamental characteristics and theories Development bio-ionic liquids or greener, environment-friendly solvents, and manifold interesting and promising applications of ionic liquid based micelles and micremulsions
Author: Joaquim Miguel Oliveira
Publisher: Springer
ISBN: 9783030422141
Category : Medical
Languages : en
Pages : 1302
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Book Description
This book provides a comprehensive analysis of microbial polysaccharides, their current uses, and highlights biomedical opportunities. The topics comprise principally a) their extraction, isolation, purification and advanced production processes; b) characterization of their structural, physicochemical, and biological properties, among others, by several techniques; c) description of the advanced functionalization and modification methods for the polysaccharide based-material; and d) their applications and uses in medical and pharmaceutical fields. Each chapter is written by world-renowned academics and practitioners on their field. This is an essential reference for students in biomedical, chemical, material, and microbiology engineering as well as researchers and professionals in the medical field.
Author: Francisca e Silva
Publisher: Royal Society of Chemistry
ISBN: 1839164697
Category : Science
Languages : en
Pages : 213
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Book Description
Modern societies produce large amounts of waste of many different types. This presents a problem in terms of management or disposal to prevent harm to human health and the environment. Additionally it represents a loss of potentially useful resources. In the circular economy concept nothing would ever become waste because everything would be re-usable or its components recoverable. Ionic liquids provide a potential route for valorisation of different waste types, paving the way for a circular economy and a more sustainable world. Covering various types of waste, including municipal, industrial, electronic, and medical, while addressing patented and commercial applications, this book aims to deliver a comprehensive, but also critical, perspective on the application of ionic liquids towards waste valorisation. Waste Valorisation Using Ionic Liquids is a useful resource for academic and industrial players, in the fields of chemistry, chemical and environmental engineering, and biotechnology, as well as anyone working on waste management and resource recovery.
Author: Mohammad Jawaid
Publisher: John Wiley & Sons
ISBN: 3527803823
Category : Technology & Engineering
Languages : en
Pages : 385
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Book Description
This first book on nanocellulose and nanohydrogels for biomedical applications is unique in discussing recent advancements in the field, resulting in a comprehensive, well-structured overview of nanocellulose and nanohydrogel materials based nanocomposites. The book covers different types of nanocellulose materials and their recent developments in the drug delivery and nanomedicine sector, along with synthesis, characterization, as well as applications in the biotechnological and biomedical fields. The book also covers the current status and future perspectives of bacterial cellulose and polyester hydrogel matrices, their preparation, characterization, and tissue engineering applications of water soluble hydrogel matrices obtained from biodegradable sources. In addition, the chitosan-based hydrogel and nanogel matrices, their involvement in the current biofabrication technologies, and influencing factors towards the biomedical sector of biosensors, biopharmaceuticals, tissue engineering appliances, implant materials, diagnostic probes and surgical aids are very well documented. Further, the history of cellulose-based and conducting polymer-based nanohydrogels, their classification, synthesis methods and applicability to different sectors, the challenges associated with their use, recent advances on the inhibitors of apoptosis proteins are also included. The recent developments and applications in the drug delivery sector gives an overview of facts about the nanofibrillated cellulose and copoly(amino acid) hydrogel matrices in the biotechnology and biomedicine field. This book serves as an essential reference for researchers and academics in chemistry, pharmacy, microbiology, materials science and biomedical engineering.
Author: Kheng-Lim Goh
Publisher: Woodhead Publishing
ISBN: 0081027311
Category : Technology & Engineering
Languages : en
Pages : 584
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Book Description
Interfaces in Particle and Fibre-Reinforced Composites: From Macro- to Nanoscale addresses recent research findings on the particle-matrix interface at different length scales. The book's main focus is on the reinforcement of materials by particles that can result in a composite material of high stiffness and strength, but it also focuses on how the particle interacts with the (matrix) material, which may be a polymer, biological-based material, ceramic or conventional metal. The different types of particle reinforced composites are discussed, as is load transfer at the particle-matrix interface. Readers will learn how to select materials and about particle structure. Significant progress has been made in applying these approaches, thus making this book a timely piece on recent research findings on the particle-matrix interface at different length scales. - Features wide coverage, from polymer, to ceramics and metal-based particulate composites - Structured in a logical order to cover fundamental studies, computer simulations, experimental techniques and characterization
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1860
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Book Description
