Studies of Some Platinum II Complexes by N.M.R. PDF Download
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Author: Joyce Margaret Edward
Publisher:
ISBN:
Category : Complex compounds
Languages : en
Pages :
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Book Description
Summary; This thesis describes the studies by NMR spectroscopy of a series of bis-(triethyl phosphine) complexes of platinum. ...
Author: Joyce Margaret Edward
Publisher:
ISBN:
Category : Complex compounds
Languages : en
Pages :
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Book Description
Summary; This thesis describes the studies by NMR spectroscopy of a series of bis-(triethyl phosphine) complexes of platinum. ...
Author: Joyce Margaret Edward
Publisher:
ISBN:
Category : Complex compounds
Languages : en
Pages : 0
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Book Description
Summary; This thesis describes the studies by NMR spectroscopy of a series of bis-(triethyl phosphine) complexes of platinum. ...
Author: Patricia Aileen Cronin
Publisher:
ISBN:
Category : Nuclear magnetic resonance
Languages : en
Pages : 450
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Book Description
Author: Emi Miyoshi
Publisher:
ISBN:
Category : DNA-ligand interactions
Languages : en
Pages :
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Book Description
Author: Catherine T. Hunt
Publisher:
ISBN:
Category : Nuclear magnetic resonance spectroscopy
Languages : en
Pages : 380
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Book Description
Author: Lori L. Bennett Slavin
Publisher:
ISBN:
Category : Nuclear magnetic resonance spectroscopy
Languages : en
Pages : 542
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Book Description
Author: Stephen B. Howell
Publisher: Springer Science & Business Media
ISBN: 030644027X
Category : Medical
Languages : en
Pages : 563
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Book Description
Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Author: Stephen Frederick Ralph
Publisher:
ISBN:
Category : Platinum compounds
Languages : en
Pages : 632
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Book Description
Author: Henry Alexander Raethel
Publisher:
ISBN:
Category : Complex compounds
Languages : en
Pages : 380
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Book Description
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241565055
Category : Medical
Languages : en
Pages : 204
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Book Description
Chapter 1. Introduction -- chapter 2. Disease burden and 2015 targets assessment -- chapter 3. TB case notifications and treatment outcomes -- chapter 4. Drug-resistant TB -- chapter 5. Diagnostics and laboratory strengthening -- chapter 6. Addressing the co-epidemics of TB and HIV -- chapter 7. Financing -- chapter 8. Research and development -- Annexes.
