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![Studies of Mammalian Brain Development by Fate Mapping and Mutant Analysis [microform] PDF](https://books.google.com/books/content/images/frontcover/tmb5tgAACAAJ?fife=w150-h200)
Author: Dawn Lenee Zinyk
Publisher: National Library of Canada = Bibliothèque nationale du Canada
ISBN: 9780612413573
Category :
Languages : en
Pages : 308
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Book Description
![Studies of Mammalian Brain Development by Fate Mapping and Mutant Analysis [microform] PDF](https://books.google.com/books/content/images/frontcover/tmb5tgAACAAJ?fife=w80-h100)
Author: Dawn Lenee Zinyk
Publisher: National Library of Canada = Bibliothèque nationale du Canada
ISBN: 9780612413573
Category :
Languages : en
Pages : 308
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Dawn Lenee Zinyk
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Mice lacking 'Engrailed-1' or 'Gli3' exhibit severe brain malformations, demonstrating that these molecules play key roles in mammalian brain development. The mouse 'En' genes are expressed in a band around the embryonic midbrain-hindbrain constriction. This region is involved in patterning of the midbrain and cerebellum and can act as an organizer region to induce midbrain and cerebellar development. Fate-mapping experiments in chick indicate that the cerebellar primordium is located anterior and posterior to the midbrain-hindbrain constriction, whereas midbrain precursors lie more anteriorly. Fate mapping in mice is complicated by the inaccessibility of the postimplantation embryo. I report a new 'in vivo' approach using the Cre/'loxP ' recombination system to map the fate of the mouse midbrain-hindbrain constriction: E9-12 cells originating in the dorsal midbrain-hindbrain constriction contribute significantly to the medial cerebellum. The feasibility of using a recombinase-based lineage-tracing system for fate mapping in mouse is demonstrated. Mice homozygous for a loss-of-function 'Gli3' mutation exhibit defective neural-tube closure in midbrain and forebrain regions, and later exencephaly. I show that: (1) 'Gli3-/-' mutants display transient ectopic 'Sonic hedgehog' (' Shh') expression in early dorsal neural folds, suggesting that Gli3 normally acts there to repress 'Shh' expression, (2) Gli3 is involved in the control of cell proliferation or cell death in the dorsal neural tube of rostral brain structures, and (3) Gli3 restricts ventrolateral expansion of 'Shh' and Shh-responsive gene expression at ventral midline in the brains of E9.5-11.5 embryos. Thus, Gli3 plays a role in the development of both dorsal and ventral neural tube at the rostral level. ' Gli3-/-' embryos were also found to exhibit abdominal heterotaxia, indicating that 'Gli3' is essential for the establishment of gut sidedness. Early somite-stage 'Gli3-/-' embryos exhibit a downregulation of 'nodal' but not ' lefty' expression in left lateral-plate mesoderm, suggesting that ' Gli3' is required for 'nodal' activation downstream of 'lefty' or in a separate pathway of left-right specification. Together, these data support the view that Gli3 genetically acts as both a repressor and activator.
Author: Peter Thorogood
Publisher:
ISBN:
Category : Bones
Languages : en
Pages : 274
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Author: Vishvanath Nene
Publisher: Springer Science & Business Media
ISBN: 3540740422
Category : Science
Languages : en
Pages : 253
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Achievements and progress in genome mapping and the genomics of microbes supersede by far those for higher plants and animals, in part due to their enormous economic implication but also smaller genome size. In the post-genomic era, whole genome sequences of animal-associated microbes are providing clues to depicting the genetic basis of the complex host-pathogen relationships and the evolution of parasitism; and to improving methods of controlling pathogens. This volume focuses on a globally important group of intracellular prokaryotic pathogens which affect livestock animals. These include Brucella, Mycobacterium, Anaplasma and Ehrlichia, as well as the protozoan pathogens Cryptosporidium and Theileria, for which genome sequence data is available. Insights from comparative genomics of the microbes described provide clues to the adaptation involved in host-microbe interactions, as well as resources potentially useful for application in future research and product development.
Author:
Publisher: Academic Press
ISBN: 0128140860
Category : Medical
Languages : en
Pages : 320
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Book Description
Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, stem cells and cancer, epigenetics and disease modeling, brain organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment. Stem Cell Epigenetics will provide researchers and physicians with a state-of-the-art map to orient across the frontiers of this fast-evolving field. Analyzes the role of epigenetics in embryonic stem cell regulation Indicates the epigenetic mechanisms involved in stem cell differentiation and highlights modifications and misregulations that may result in disease pathogenesis Examines the potential applications of stem cell epigenetics in therapeutic disease interventions and regenerative medicine, providing a foundation for researchers and physicians to bring this exciting and fast-evolving field into a clinical setting Features chapter contributions by leading international experts
Author: Brian Hare
Publisher: Random House
ISBN: 0399590676
Category : Psychology
Languages : en
Pages : 304
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Book Description
A powerful new theory of human nature suggests that our secret to success as a species is our unique friendliness “Brilliant, eye-opening, and absolutely inspiring—and a riveting read. Hare and Woods have written the perfect book for our time.”—Cass R. Sunstein, author of How Change Happens and co-author of Nudge For most of the approximately 300,000 years that Homo sapiens have existed, we have shared the planet with at least four other types of humans. All of these were smart, strong, and inventive. But around 50,000 years ago, Homo sapiens made a cognitive leap that gave us an edge over other species. What happened? Since Charles Darwin wrote about “evolutionary fitness,” the idea of fitness has been confused with physical strength, tactical brilliance, and aggression. In fact, what made us evolutionarily fit was a remarkable kind of friendliness, a virtuosic ability to coordinate and communicate with others that allowed us to achieve all the cultural and technical marvels in human history. Advancing what they call the “self-domestication theory,” Brian Hare, professor in the department of evolutionary anthropology and the Center for Cognitive Neuroscience at Duke University and his wife, Vanessa Woods, a research scientist and award-winning journalist, shed light on the mysterious leap in human cognition that allowed Homo sapiens to thrive. But this gift for friendliness came at a cost. Just as a mother bear is most dangerous around her cubs, we are at our most dangerous when someone we love is threatened by an “outsider.” The threatening outsider is demoted to sub-human, fair game for our worst instincts. Hare’s groundbreaking research, developed in close coordination with Richard Wrangham and Michael Tomasello, giants in the field of cognitive evolution, reveals that the same traits that make us the most tolerant species on the planet also make us the cruelest. Survival of the Friendliest offers us a new way to look at our cultural as well as cognitive evolution and sends a clear message: In order to survive and even to flourish, we need to expand our definition of who belongs.
Author: Heinrich Klefenz
Publisher: Wiley-VCH
ISBN:
Category : Medical
Languages : de
Pages : 328
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Book Description
This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.
Author: Frederick Marcus
Publisher: Springer Science & Business Media
ISBN: 3540783539
Category : Science
Languages : en
Pages : 296
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Book Description
Collaborative research in bioinformatics and systems biology is a key element of modern biology and health research. This book highlights and provides access to many of the methods, environments, results and resources involved, including integral laboratory data generation and experimentation and clinical activities. Collaborative projects embody a research paradigm that connects many of the top scientists, institutions, their resources and research worldwide, resulting in first-class contributions to bioinformatics and systems biology. Central themes include describing processes and results in collaborative research projects using computational biology and providing a guide for researchers to access them. The book is also a practical guide on how science is managed. It shows how collaborative researchers are putting results together in a way accessible to the entire biomedical community.
Author: Mark D. Kilby
Publisher: Cambridge University Press
ISBN: 1107012139
Category : Medical
Languages : en
Pages : 471
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Book Description
Covers the latest insights any fetal specialist needs and provides essential knowledge for professionals caring for women with high-risk pregnancies.
