Structure-function Analysis of DNA Polymerase-[beta] Using Monoclonal Antibodies PDF Download
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![Structure-function Analysis of DNA Polymerase-[beta] Using Monoclonal Antibodies PDF](https://books.google.com/books/content/images/frontcover/genttwAACAAJ?fife=w150-h200)
Author: Anthony J. Recupero
Publisher:
ISBN:
Category :
Languages : en
Pages : 242
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![Structure-function Analysis of DNA Polymerase-[beta] Using Monoclonal Antibodies PDF](https://books.google.com/books/content/images/frontcover/genttwAACAAJ?fife=w80-h100)
Author: Anthony J. Recupero
Publisher:
ISBN:
Category :
Languages : en
Pages : 242
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Author: Jessica Lang Kosa
Publisher:
ISBN:
Category :
Languages : en
Pages : 346
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Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Author: Melvin L. DePamphilis
Publisher: CSHL Press
ISBN: 0879697660
Category : Medical
Languages : en
Pages : 814
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Book Description
At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed. At least 160 proteins are involved in replicating the human genome, and at least 40 diseases are caused by aberrant DNA replication, 35 by mutations in genes required for DNA replication or repair, 7 by mutations generated during mitochondrial DNA replication, and more than 40 by DNA viruses. Consequently, a growing number of therapeutic drugs are targeted to DNA replication proteins. This authoritative volume provides a rich source of information for researchers, physicians, and teachers, and will stimulate thinking about the relevance of DNA replication to human disease.
Author:
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ISBN:
Category : Medicine
Languages : en
Pages : 1860
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1104
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1064
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 742
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Author: Edward D. Zanders
Publisher: John Wiley & Sons
ISBN: 111884985X
Category : Science
Languages : en
Pages : 454
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Book Description
The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates. The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book. Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum. Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.
Author:
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ISBN:
Category : Cytology
Languages : en
Pages : 604
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