Structure and Function in Peptides with Natural and Non-natural Backbones PDF Download
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Author: Jonathan Robert Lai
Publisher:
ISBN:
Category :
Languages : en
Pages : 422
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Book Description
Author: Jonathan Robert Lai
Publisher:
ISBN:
Category :
Languages : en
Pages : 422
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Book Description
Author: Tom W. Muir
Publisher: Academic Press
ISBN: 9780123743107
Category : Medical
Languages : en
Pages : 264
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Book Description
By combining the tools of organic chemistry with those of physical biochemistry and cell biology, 'Non-Natural Amino Acids' aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. This volume brings together the tools and principles of chemistry with the molecules and processes of living cells to create molecules with new properties and functions found neither in nature nor in the test tube. By studying the structure and function of these resulting molecules, new insights can be gained into the molecular mechanisms of complex biological and chemical systems. Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube. By studying the structure and function of non-natural molecules, new insights can be gained into the molecular mechanisms of complex biological and chemical systems. Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
Author:
Publisher: Academic Press
ISBN: 9780080921631
Category : Science
Languages : en
Pages : 350
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Book Description
By combining the tools of organic chemistry with those of physical biochemistry and cell biology, Non-Natural Amino Acids aims to provide fundamental insights into how proteins work within the context of complex biological systems of biomedical interest. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. With more than 400 volumes published, each Methods in Enzymology volume presents material that is relevant in today's labs -- truly an essential publication for researchers in all fields of life sciences. Demonstrates how the tools and principles of chemistry combined with the molecules and processes of living cells can be combined to create molecules with new properties and functions found neither in nature nor in the test tube Presents new insights into the molecular mechanisms of complex biological and chemical systems that can be gained by studying the structure and function of non-natural molecules Provides a "one-stop shop" for tried and tested essential techniques, eliminating the need to wade through untested or unreliable methods
Author: Antonio Guarna
Publisher: John Wiley & Sons
ISBN: 1119950600
Category : Science
Languages : en
Pages : 334
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Book Description
A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
![Development of [alpha/beta]-peptide Foldamer Tertiary and Quaternary Structure PDF](https://books.google.com/books/content/images/frontcover/Tr8IAQAAMAAJ?fife=w80-h100)
Author: Joshua Lloyd Price
Publisher:
ISBN:
Category :
Languages : en
Pages : 372
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Book Description
Author: Jean-François Lutz
Publisher: John Wiley & Sons
ISBN: 3527342370
Category : Technology & Engineering
Languages : en
Pages : 532
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Book Description
Edited by a leading authority in the field, the first book on this important and emerging topic provides an overview of the latest trends in sequence-controlled polymers. Following a brief introduction, the book goes on to discuss various synthetic approaches to sequence-controlled polymers, including template polymerization, genetic engineering and solid-phase chemistry. Moreover, monomer sequence regulation in classical polymerization techniques such as step-growth polymerization, living ionic polymerizations and controlled radical polymerizations are explained, before concluding with a look at the future for sequence-controlled polymers. With its unique coverage of this interdisciplinary field, the text will prove invaluable to polymer and environmental chemists, as well as biochemists and bioengineers.
Author:
Publisher: Elsevier
ISBN: 0443218153
Category : Science
Languages : en
Pages : 400
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Book Description
Peptide Chemical Tools for Modulating Biology, Volume 698 in the esteemed Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting topics on Peptide tools that target telomere maintenance, Molecular Design of Peptide Therapeutics, Sulfonyl peptide tools for modulating biology, Peptide tools for targeting the Crk/CrkL-p130Cas axis, Quorum sensing peptide tools, In vivo stability and BBB penetration of peptide tools, and Oligo-benzamide-based peptide mimicking tools for modulating biology. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology Updated release includes the latest information on Peptide Chemical Tools for Modulating Biology
Author: Hardy J. Rideout
Publisher: Springer
ISBN: 3319499696
Category : Medical
Languages : en
Pages : 271
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Book Description
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 764
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Book Description
Author: Zigang Li
Publisher: John Wiley & Sons
ISBN: 3527343458
Category : Science
Languages : en
Pages : 242
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Book Description
An important and timely guide to the progress being made on constrained helical peptides Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity. The book examines the therapeutic applications of the constraint helices and includes comparison with existing small molecule modulators or antibodies. Designed as a useful resource for both those outside and inside the field. Those new to the field will find a comprehensive introduction to cyclized helical peptide and those inside the field will find a deeper understanding of the topic. This important book: Offers a practical introduction to constrained helical peptides Includes all aspects of constrained helical peptides Includes information on the most recent methods that have emerged Presents a guide to help solve practical problems in the field Written for academics, pharmaceutical professional, Cyclized Helical Peptides is a comprehensive guide to the developments of constrained helical peptides.
