Story Of Interferon, The: The Ups And Downs In The Life Of A Scientist PDF Download
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Author: Kari Cantell
Publisher: World Scientific
ISBN: 9814497363
Category : Medical
Languages : en
Pages : 267
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Book Description
The Finnish doctor Kari Cantell is one of the scientists to whom the development of the drugs called interferons can be attributed. Interferons have achieved an important place in the treatment of cancer, viral infections and multiple sclerosis. In the 1960s Cantell and his coworkers developed a method for the preparation of interferon in white blood cells. During those years, most of the global production of interferon took place in Finland and the vast majority of the clinical studies in the world employed Finnish interferon.The memoirs of Cantell record interferon's long road from the laboratory to the pharmacy shelf. The journey took more than three decades and involved moments of triumph as well as desperation in the lives of many scientists.The book will give the reader a glimpse of the world of science; how research is carried out in the laboratory and the clinic; how the mind of the scientist operates and how he experiences success and failure; how warm friendships and bitter conflicts develop between investigators; how the involvement of money and politics harms as well as helps research.The Interferon Story is a richly rewarding book written for ordinary people without a basic knowledge of biology or medicine. It can be read as a thriller describing the struggle of scientists against the most feared diseases of mankind.
Author: Kari Cantell
Publisher: World Scientific
ISBN: 9814497363
Category : Medical
Languages : en
Pages : 267
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Book Description
The Finnish doctor Kari Cantell is one of the scientists to whom the development of the drugs called interferons can be attributed. Interferons have achieved an important place in the treatment of cancer, viral infections and multiple sclerosis. In the 1960s Cantell and his coworkers developed a method for the preparation of interferon in white blood cells. During those years, most of the global production of interferon took place in Finland and the vast majority of the clinical studies in the world employed Finnish interferon.The memoirs of Cantell record interferon's long road from the laboratory to the pharmacy shelf. The journey took more than three decades and involved moments of triumph as well as desperation in the lives of many scientists.The book will give the reader a glimpse of the world of science; how research is carried out in the laboratory and the clinic; how the mind of the scientist operates and how he experiences success and failure; how warm friendships and bitter conflicts develop between investigators; how the involvement of money and politics harms as well as helps research.The Interferon Story is a richly rewarding book written for ordinary people without a basic knowledge of biology or medicine. It can be read as a thriller describing the struggle of scientists against the most feared diseases of mankind.
Author: Toine Pieters
Publisher: Routledge
ISBN: 1134293054
Category : Business & Economics
Languages : en
Pages : 347
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Book Description
This innovative study charts the beginnings, history and fate of Interferon - one of modern medicine's most famous and infamous drugs. Interferon is part of the medical profession's armoury against viral infection, cancer and MS. The story of its development and use is one of survival in the face of remarkable cycles of promise and disappointment as a miracle drug. By telling this story, Toine Pieters' book provides insight into the research, manufacture, and marketing of new bio-molecules that mark modern medical science. Pieters' closely argued book adopts a multi-disciplinary approach in seeking to trace the extraordinary voyage of interferon. Through the lens of interferon's voyage, the book explores the interaction of the broad range of actors driving medical science: *biological and clinical researchers *the pharmaceutical industry *high-powered government agencies *doctors and patients *the media. The book demonstrates how research on interferon led to new clinical definitions of cancer and a new rationale for therapeutic use of the drug. Interferon provides a marvellous insight into the development of one of the most controversial drugs of our time. It enhances our understanding of how medicine manufacture and marketing all played a part in pushing back the boundaries of research, from the post-penicillin era to the genetics revolution in medicine. This study is of particular interest to undergraduates and postgraduates in the fields of History of Medicine, Pharmacology, Medical Genetics and History of Science.
Author: J. Lindenmann
Publisher: Springer Science & Business Media
ISBN: 3662037874
Category : Medical
Languages : en
Pages : 149
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Book Description
Forty years of Interferon I wish to dedicate this short introduction to the memory of Alick Isaacs (1921-1967), and to that of Sir Christopher Andrewes (1896-1988). Let us go back more than 40 years. In 1956 Isaacs was in charge of the Wodd Influenza Centre. Andrewes was head of the division of bac teriology and virology, and deputy director of the National Institute for Medical Research in London. When researchers are faced with a seemingly new phenomenon, ex planations are easy to come by. These explanations fall into two broad categories: the phenomenon in question is either due to something or to the lack of something. I apologize for the primitive way in which I ex press this, but I am going to give three examples, scattered over 100 years, of what I mean. First example: in 1880 the great French microbiologist Louis Pas teur was involved in work on chicken cholera. He was struck by the following observation: if a suitable chicken broth was inoculated with the bacterium, the organism grew profusely and the liquid became tur bid. If he now freed the fluid, by sedimentation or filtration, from the bulk of the organisms and re-inoculated it with the same bacterium, no growth occurred.
Author: Tristan Vaughan
Publisher: John Wiley & Sons
ISBN: 3527699139
Category : Medical
Languages : en
Pages : 754
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Book Description
In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.
Author: Teri Shors
Publisher: Jones & Bartlett Publishers
ISBN: 1284025926
Category : Medical
Languages : en
Pages : 969
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Book Description
Understanding Viruses continues to set the standard for the fundamentals of virology. This classic textbook combines molecular, clinical, and historical aspects of human viral diseases in a new stunning interior design featuring high quality art that will engage readers. Preparing students for their careers, the Third Edition greatly expands on molecular virology and virus families. This practical text also includes the latest information on influenza, global epidemiology statistics, and the recent outbreaks of Zika and Ebola viruses to keep students on the forefront of cutting-edge virology information. Numerous case studies and feature boxes illuminate fascinating research and historical cases stimulate student interest, making the best-selling Understanding Viruses the clear choice in virology. Each new print copy includes Navigate 2 Advantage Access that unlocks a comprehensive and interactive eBook, student practice activities and assessments, a full suite of instructor resources (available to adopting instructors with course ID), and learning analytics reporting tools (available to adopting instructors with course ID).
Author: Joseph Cummins
Publisher: Simon and Schuster
ISBN: 1510765514
Category : Science
Languages : en
Pages : 233
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Book Description
Touted as a potential breakthrough cancer therapy in the 1980s by the scientific community and publications such as TIME and Newsweek magazine, the reputation of interferon has not lived up to its early promise. Interferons are small proteins with anti-viral and anti-cancer effects, which have the power to modulate the functioning of the immune system. But Dr. Joseph Cummins, an early interferon pioneer, holder of sixteen US medical patents, author of more than sixty scientific publications, as well as having taught veterinary medicine at the University of Missouri, University of Illinois, and Texas A & M University, argues that the current thinking on interferon is fundamentally flawed. Interferon is created in small quantities in the body in response to infection, and seems to work best at these low dosages. However, the public health cowboys, working under the assumption that anything good in tiny amounts must be better in massive amounts, pursued exactly the wrong strategy. High-dose interferon does not work in the body and may even cause problems. The first remarkable results for interferon and the flu were reported by the Soviets in the 1970s, but Western medicine discounted these findings because they believed the dosages were so low they couldn’t possibly be effective. In the 1980s, when interferon was expensive to produce and only small quantities could be manufactured, the results were remarkable. Dr. Cummins was an early pioneer of low-dose interferon, and his remarkable findings among animals led to collaborations with medical doctors for human trials, even going so far as Africa at the height of the HIV-AIDS epidemic. Cummins reviews the evidence for this inexpensive, safe treatment and makes an eloquent argument for medical science to take another look at interferon to tackle today’s most challenging health conditions, including COVID-19.
Author: Eric H. Boehm
Publisher:
ISBN:
Category : History, Modern
Languages : en
Pages : 438
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Book Description
Author: Greg Whitesides
Publisher: Cambridge University Press
ISBN: 1108356052
Category : History
Languages : en
Pages : 705
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Book Description
The sciences played a critical role in American foreign policy after World War II. From atomic energy and satellites to the green revolution, scientific advances were central to American diplomacy in the early Cold War, as the United States leveraged its scientific and technical pre-eminence to secure alliances and markets. The growth of applied research in the 1970s, exemplified by the biotech industry, led the United States to promote global intellectual property rights. Priorities shifted with the collapse of the Soviet Union, as attention turned to information technology and environmental sciences. Today, international relations take place within a scientific and technical framework, whether in the headlines on global warming and the war on terror or in the fine print of intellectual property rights. Science and American Foreign Relations since World War II provides the historical background necessary to understand the contemporary geopolitics of science.
Author: Daniel M. Davis
Publisher: University of Chicago Press
ISBN: 022637114X
Category : Medical
Languages : en
Pages : 271
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Book Description
“A terrific book by a consummate storyteller and scientific expert considers the past and future of the body’s ability to fight disease and heal itself.” —Adam Rutherford, The Guardian The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body’s ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major advances in our grasp of this breathtakingly beautiful inner world: a vast and intricate network of specialist cells, regulatory proteins, and dedicated genes that are continually protecting our bodies. Far more powerful than any medicine ever invented, the immune system plays a crucial role in our daily lives. We have found ways to harness these natural defenses to create breakthrough drugs and so-called immunotherapies that help us fight cancer, diabetes, arthritis, and many age-related diseases, and we are starting to understand whether activities such as mindfulness might play a role in enhancing our physical resilience. Written by a researcher at the forefront of this adventure, The Beautiful Cure tells a dramatic story of scientific detective work and discovery, of puzzles solved and mysteries that linger, of lives sacrificed and saved. With expertise and eloquence, Davis introduces us to this revelatory new understanding of the human body and what it takes to be healthy. “Visceral.” —The Wall Street Journal “Illuminating.” —Publishers Weekly “Heroic.” —Science
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 748
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Book Description
