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Author: Alexandru Mihai Grumezescu
Publisher: William Andrew
ISBN: 0128136901
Category : Science
Languages : en
Pages : 838
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Book Description
Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. - Shows how the use of nanomaterials can help target a drug to specific tissues and cells - Explores the development of stimuli-responsive drug delivery systems - Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy
Author: Alexandru Mihai Grumezescu
Publisher: William Andrew
ISBN: 0128136901
Category : Science
Languages : en
Pages : 838
Get Book Here
Book Description
Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. - Shows how the use of nanomaterials can help target a drug to specific tissues and cells - Explores the development of stimuli-responsive drug delivery systems - Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy
Author: Ajit Behera
Publisher: CRC Press
ISBN: 1040032184
Category : Technology & Engineering
Languages : en
Pages : 444
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Book Description
Smart drug delivery at both the micro- and nanoscale is an evolving field with numerous potential applications. It has the potential to revolutionize drug therapy by making treatments more effective, reducing side effects, and improving patient outcomes. This book presents a comprehensive review of the most recent studies on smart micro- and nanomaterials with a focus on their “smart” activity for formation of targeted and responsive drug-delivery carriers. This volume: Introduces readers to the fundamentals of these the micro- and nanoscale materials as well as approaches to smart drug delivery and drug delivery systems. Covers polymers, metals, and composite materials as well as quantum dots and carbon nanotubes. Describes of all possible stimulated systems for drug delivery such as enzyme-responsive, small molecules-responsive, thermo-responsive, pH-responsive, electric field-responsive, magnetic field-responsive, light-responsive, ultrasound-responsive, and reductive environment responsive. Offers a critical perspective on the future scope of smart drug delivery systems. This reference work is written to support researchers in the fields of materials engineering and biotechnology with the goal of improving the diagnosis and treatment of disease and patient quality of life.
Author: Anand Krishnan
Publisher: Springer Nature
ISBN: 3030803716
Category : Science
Languages : en
Pages : 796
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Book Description
Over the past decade the world has seen the rise of the fascinating and diverse field currently recognized as nanotechnology. This book covers a broad spectrum of topics within nanotechnology, including synthesis techniques, various innovative characterization techniques, growth mechanisms of nanomaterials, the physics and chemistry of nanomaterials, diverse functionalization methods, and the various applications of nanomaterials in biology, therapeutics, energy, food science, and environmental science. It also discusses applications of nanostructured materials, integrative applications such as nano- and micro-electronic sensor devices, as well as agricultural and environmental remediation applications. The book also includes a discussion of advances in functionalized nanomaterials (0D, 1D, 2D and 3D) and covers the early stages of the development of functionalized nanostructures, considering the future for 2D nanomaterials and 3D objects. Additionally, it includes a chapter on nanomaterial research development that highlights work on the life-cycle analysis of nanostructured materials and toxicity aspects. This book proves useful for researchers and professionals working in the field of nanomaterials and green technology, as well as in the field of nanotechnology. It should be useful to students and specialized researchers in a number of disciplines ranging from biology, chemistry, and materials science to engineering and manufacturing in both academia and industry.
Author: Muhammad Raza Shah
Publisher: Elsevier
ISBN: 0443223882
Category : Technology & Engineering
Languages : en
Pages : 396
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Book Description
Stimuli-Responsive Nanocarriers for Targeted Drug Delivery presents a comprehensive overview of the most significant physical and chemical stimuli-responsive drug delivery systems. This book reviews targeted and controlled drug delivery systems and how nanocarriers can be used to improve the pharmacokinetics of drugs in biological systems, such as increasing utilization rate and reducing toxicity and side effects. After a key introduction to the topic, a range of nanocarrier types is assessed before exploring the clinical translation challenges and considerations involved.This book is a useful resource for researchers and postgraduate students in the fields of materials science, nanotechnology, pharmaceutical science, and medicinal chemistry. - Offers an in-depth look at the basic and fundamental aspects of stimuli-responsive materials, mechanisms, structure, synthesis and properties - Provides information about well-defined categorization for stimuli-responsive drug delivery system based on different triggering mechanisms to its reader - Reviews basic concepts and the latest research involving advances in stimuli-responsive drug delivery systems in controlled-release drugs - Discusses novel approaches and challenges for scaling-up and commercialization of stimuli-responsive polymers
Author: Seyed Morteza Naghib
Publisher: Bentham Science Publishers
ISBN: 9815051644
Category : Medical
Languages : en
Pages : 266
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Book Description
This book provides a comprehensive overview of the localized drug delivery system landscape. The 10 chapters provide a detailed introduction in polymers, nanostructures and nanocomposites for developing localized controlled drug delivery systems (LCDDSs) in the form of stimuli-responsive delivery systems, targeted drug delivery systems or the combination of both. A discussion on manufacturing techniques, optimization, challenges and adaptation of LCDDSs for the treatment of a wide range of diseases is also included. This simple and informative resource conveys an understanding about designing novel drug delivery systems to students in advanced pharmacology, biotechnology, materials science and biochemistry study programs. Readers will be equipped with the knowledge of regulating drug release rates to get a desired pharmacological profile, that helps a researcher to ensure a high therapeutic effectiveness. The detailed information about various drug delivery systems and a compilation of recent literature sources also paves the way for research scholars to construct a drug targeting framework for their research plans.
Author: Virendra Gajbhiye
Publisher: Academic Press
ISBN: 0323859046
Category : Medical
Languages : en
Pages : 485
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Book Description
Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understand and progress stimuli-responsive nanocarriers. The book contains recent advancements made in the field of stimuli-responsive nanocarriers with their application in controlled drug delivery against various diseases. It focuses on the design, mechanism, construction, therapeutic application and future challenges of stimuli-responsive nanocarriers which will help new researchers in designing next generation tailor-made advanced therapeutics. Finally, the book covers future aspects and challenges present in the route of development of stimuli responsive nanocarriers for disease therapeutics. Various recent advances and biomedical applications assembled in this book will guide scientists on how to design and develop novel controlled drug release systems. - Provides comprehensive knowledge of basic design, mechanism and construction of nanocarrier based stimuli-responsive drug releases - Explores various nanocarriers characteristically used in the development of stimuli-responsive drug release systems - Envisages future opportunities, challenges and implementation of nanocarrier based stimuli-responsive drug release systems in disease therapeutics
Author: Meng Bi Zhang
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
The use of nanomaterials for biomedical applications is an emerging and important field. This is particularly true of advancements in targeted and controlled drug delivery, which offer several important improvements over traditional drug administration. The clinical efficacy of small-molecule therapeutics is currently limited by many factors, including: poor solubility, inefficient cellular uptake, overly rapid renal clearance and an inability to target only desired locations such as diseased tissues. The use of nanocarriers for drug delivery may greatly improve the efficacy over traditional therapeutics by lowering the total dosage, limiting the exposure to affected areas only, and giving greater temporal control over drug elution. These materials often make use of both organic and inorganic components, exploiting the unique and useful properties of each constituent to achieve novel, synergistic functions. This dissertation presents a study of nanocomposites comprising the three most important materials in this field: titania, iron oxides and polypyrrole. Titania is a strong photocatalyst, iron oxides provide useful responses to applied magnetic fields, and polypyrrole is a polymer with unique electrochemical properties. Studies in this dissertation were aimed at combining these three materials to create a novel structure that is responsive towards light, magnetic fields and electrical stimulation to serve as an enabling platform for the loading and release of biologically interesting compounds. These nanomaterials have been paired with amino acids L-lysine and L-glutamic acid, two organic molecules of interest due to their ability to bind to DNA and proteins, and to form prodrugs that exhibit enhanced performance compared to traditionally administered medicines. Two model compounds have been loaded and released on these carriers: Ketoprofen, an important anti-inflammatory that is traditionally hindered by its limited cellular uptake levels; and fluorescein isothiocyanate, a fluorescent dye molecule that is a common tool used in this field for nanocarrier location and easy visualisation of release-related kinetics. First, an investigation into the effect of pH on the binding of amino acids to titania, iron oxide and polypyrrole is presented with a view towards optimising the functionalised material for subsequent loading and release of the model drugs (in this case, amine-reactive molecules). The release mechanism of photo-activated TiO2 is studied in detail with a particular focus on the competition between the cleavage of bonds versus organic degradation on the catalyst's surface. Both mechanisms are currently reported in literature and studies were aimed at identifying the more dominant pathway in the system developed alongside understanding the crucial role of reaction time scales on this photochemistry. Then, the pH-tuneable flocculation of the amino acid-functionalised nanoparticles via electrostatic attractions is exploited to create a novel, anisotropic assembly of iron oxides. These filaments display a dynamic and unique response towards a rotating magnetic field by creating local microscale vortices. This motion is used to enhance local delivery rate of molecules through magnetic-field triggered microscale mixing. Finally, this anisotropic iron oxide structure is combined with polypyrrole to create a unique, novel material that possesses directional conductivity, a photothermal response, and magnetic field-triggered release of loaded molecules at enhanced and controllable rates compared with traditional diffusion-limited systems.
Author: Lin Zhu
Publisher: CRC Press
ISBN: 100073336X
Category : Medical
Languages : en
Pages : 406
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Book Description
The response to the environmental and internal stimuli is one of the basic characteristics of living organisms. Inspired by this natural strategy and fast developing nanotechnology and materials science, currently, stimuli-responsive nanomedicine emerges as an active and important field of nanomedicine. This book offers a fundamental and comprehensive overview of stimuli-responsive nanomedicine, and also compiles and details its recent cutting-edge findings and most impressive achievements in biomedical applications, from a pharmaceutical science perspective, making it the first book in this field. By providing readers a broad and in-depth coverage of endogenous and exogenous stimuli as well as their applicable nanomedicines, this book is valuable for students, researchers, and educators in biomedical sciences or anyone interested in this burgeoning field.
Author: Ajeet Kaushik
Publisher: Springer
ISBN: 3319636332
Category : Medical
Languages : en
Pages : 245
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Book Description
Personalized health care to manage diseases and optimized treatment is crucial for everyone to maintain health quality. Significant efforts have been made to design and develop novel nano-enabling therapeutic strategies to cure and monitor diseases for personalized health care. As state-of-the-art, various strategies have been reported to develop personalized nanomedicine to combat against target diseases with no side effects. In this book proposal, we are trying to describe fundamentals of personalized nanomedicine, novel nanomaterials for drug delivery, role of nanotechnology for efficient therapeutics approach, nano-pharmacology, targeted CNS drug delivery, stimuli responsive drug release and nanotechnology for diseases management. This book would serve as a platform for new scholars to understand state-of-the-art of nanotechnology for therapeutics and designing their future research to develop effective personalized nanomedicine against targeted diseases. As of now, various studies have been reported to design and develop nanomedicines of higher efficacy but unfortunately, such products are up to laboratory research only and need to be well-tested using pre-clinical or human models. Our book would be a call for experts to explore multidisciplinary research for developing novel and efficient approaches to explore smart efficient nanocarriers for site-specific on-demand controlled drug delivery to combat against targeted diseases to personalized health care.
Author: Sougata Jana
Publisher: John Wiley & Sons
ISBN: 3527349049
Category : Science
Languages : de
Pages : 1063
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Book Description
A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.
