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Author: Yoshiaki Kawashima
Publisher: Springer
ISBN: 9811367868
Category : Medical
Languages : en
Pages : 118
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Book Description
This book describes the principles and applications of the spherical crystallization technique, from the standpoint of its inventor. After an introduction on the history of particle design engineering and nanotechnology, the concept of spherical crystallization itself is clearly explained. Attention then turns to the application of spherical crystallization in pharmaceutical processes. It is explained how the technique can provide physicochemical properties suitable for direct tableting of active pharmaceutical ingredients and how it has enabled the development of a novel particulate design platform from single to complex system. Subsequent chapters describe the roles of polymeric spherical crystallization in the preparation of novel microspheres, microballoons for drug delivery systems (DDS) and the development of biocompatible and biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanospheres. The various applications of PLGA nanospheres composite within oral-, pulmonary-, transdermal DDS and cosmetics are fully discussed. Finally, future perspectives are presented on use of the technology in the design and industrial-scale manufacture of new drug delivery systems, highlighting how a continuous pharmaceutical process that meets US Food and Drug Administration quality requirements should soon be introduced.
Author: Yoshiaki Kawashima
Publisher: Springer
ISBN: 9811367868
Category : Medical
Languages : en
Pages : 118
Get Book Here
Book Description
This book describes the principles and applications of the spherical crystallization technique, from the standpoint of its inventor. After an introduction on the history of particle design engineering and nanotechnology, the concept of spherical crystallization itself is clearly explained. Attention then turns to the application of spherical crystallization in pharmaceutical processes. It is explained how the technique can provide physicochemical properties suitable for direct tableting of active pharmaceutical ingredients and how it has enabled the development of a novel particulate design platform from single to complex system. Subsequent chapters describe the roles of polymeric spherical crystallization in the preparation of novel microspheres, microballoons for drug delivery systems (DDS) and the development of biocompatible and biodegradable poly(D,L-lactide-co-glycolide) (PLGA) nanospheres. The various applications of PLGA nanospheres composite within oral-, pulmonary-, transdermal DDS and cosmetics are fully discussed. Finally, future perspectives are presented on use of the technology in the design and industrial-scale manufacture of new drug delivery systems, highlighting how a continuous pharmaceutical process that meets US Food and Drug Administration quality requirements should soon be introduced.
Author: Olga Arsenyeva
Publisher: Springer Nature
ISBN: 3031468775
Category : Technology & Engineering
Languages : en
Pages : 480
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Book Description
This book offers a comprehensive review of smart technologies and provides perspectives on their applications in urban engineering. It covers a wide range of applications, from manufacturing engineering and transport logistics to information and computation technologies, providing readers with fresh ideas for future research and collaborations. The book showcases selected papers from the International Conference on Smart Technologies in Urban Engineering (STUE-2023), hosted by O.M. Beketov National University of Urban Economy in Kharkiv, Ukraine. The conference, held on June 8–10, 2023, aimed to address the complex rehabilitation of areas damaged by military conflicts and natural disasters. The contributions within this book offer a wealth of valuable information, fostering a meaningful exchange of experiences among scientists in the field of urban engineering. By delving into this book, readers explore innovative approaches to tackle urban challenges, gain insights from experts, and contribute to the advancement of smart technologies for the betterment of cities worldwide.
Author: Justin Louie Quon
Publisher:
ISBN:
Category :
Languages : en
Pages : 107
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Book Description
The control of crystallization steps is essential in the production of many materials in the pharmaceutical, materials, and chemical industries. Additionally, due to increasing costs of research and development, reductions in manufacturing costs by moving from batch to continuous manufacturing are necessary to sustain profitability of the pharmaceutical industry. Two different projects were researched to progress towards this goal. The first was the demonstration of a continuous manufacturing platform. The second goal was the development of new crystallization techniques. Two continuous crystallization processes were developed as part of a demonstration unit for continuous manufacturing of Aliskiren hemifumarate. The first process was an anti-solvent crystallization of an intermediate. The second process was a continuous reactive crystallization developed for the final product. The processes were able to crystallize the two compounds with both high yield (>90%) and purity (>99%). Population balance modeling was performed and experimental data were fit to the model to obtain kinetic parameters for crystal growth and nucleation for both systems. The models were used to optimize crystal purity and yield of the products. In addition, this thesis describes two separate projects involving spherical agglomerates. In the first study, acetaminophen was shown to crystallize significantly faster in the presence of spherical agglomerates of lactose than single crystal lactose. An epitaxy study and molecular dynamics simulations showed that the (141̄)/(001) pairing of faces showed coincident lattice matching and favorable energy interaction. Maximizing the number of substrate faces available for interaction increases the chance for a lattice match between the substrate and the crystallizing material which can be useful for controlling and increasing nucleation kinetics. Finally, water-in-oil emulsions were used to make composite spherical agglomerates with two components: a heterosurface, and a target compound that does not typically crystallize as spherical agglomerates on its own. The generated composite agglomerates were relatively monodisperse and were characterized using optical microscopy, scanning electron microscopy, x-ray powder diffraction, and differential scanning calorimetry. This technique could potentially be applied to other hydrophilic compounds, in particular water-soluble pharmaceuticals compounds, in order to change crystal morphology to spherical agglomerates in order to simplify downstream processing.
Author: Chad A. Mirkin
Publisher: CRC Press
ISBN: 1000092356
Category : Science
Languages : en
Pages : 510
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Book Description
Spherical nucleic acids (SNAs) comprise a nanoparticle core, and a densely packed and highly oriented nucleic acid shell. They have novel structure-dependent properties that differ from those of linear nucleic acids and that makes them useful in chemistry, biology, the life sciences, medicine, materials science, and engineering. This book is a reprint volume that compiles 101 key papers that have been published by the Mirkin Group at Northwestern University, USA, and their collaborators over the past more than two decades. Volume 1 provides an overview and a historical framework of SNAs and discusses their enabling features, which set them apart from all other forms of matter. Volume 2 covers the general design rules for colloidal crystal engineering with DNA, spanning the building blocks and DNA- and RNA-based "programmable bonds" that can be utilized in preparing such structures. Volume 3 continues the discussion of colloidal crystallization processes and routes to hierarchical assembly, featuring dynamic nanoparticle superlattices and lattices prepared on surfaces or via templating strategies, and explores what one can uniquely learn from and do with colloidal crystals prepared from nucleic acid–functionalized nanomaterials in optics, plasmonics, and catalysis. Volume 4 covers the role of SNAs in biomedicine, especially as diagnostic probes both inside and outside of cells, and treatments based on gene regulation and immunotherapy.
Author:
Publisher:
ISBN:
Category : Chemical engineering
Languages : en
Pages : 558
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Book Description
Author: Alan G. Jones
Publisher: Butterworth-Heinemann
ISBN: 0750655208
Category : Science
Languages : en
Pages : 362
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Book Description
Particulate Crystal Characteristics; Fluid-particle Transport Processes; Crystallization Principles and Techniques; Crystal Formation Processes; Crystallizer Design and Operation; Solid-Liquid Separation Processes; Design of Crystallization Process Systems.
Author: Michael E. Aulton
Publisher: Elsevier Health Sciences
ISBN: 0702042900
Category : Medical
Languages : en
Pages : 909
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Book Description
"Pharmaceutics is the art of pharmaceutical preparations. It encompasses design of drugs, their manufacture and the elimination of micro-organisms from the products. This book encompasses all of these areas."--Provided by publisher.
Author: Jim Litster
Publisher: Cambridge University Press
ISBN: 1107007372
Category : Science
Languages : en
Pages : 343
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Book Description
A unique text providing comprehensive coverage of fundamental particle science, processing and technology. Including quantitative tools, real-world case studies and end-of-chapter problems, it is ideal for students in engineering and applied sciences, as well as for practitioners in a range of industries manufacturing particulate products.
Author: Piyush Pradeep Mehta
Publisher: Springer Nature
ISBN: 9819919231
Category : Medical
Languages : en
Pages : 465
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Book Description
This book provides an insight into state-of-art developments in pulmonary drug delivery systems. It comprises several chapters covering a wide range of promising technologies and novel materials explored for developing effective pulmonary drug delivery systems. The initial book chapters elucidate role of thin film freezing, supercritical fluid technology, nano-in-micro particles system, crystal-engineered microstructures and porous particles in pulmonary drug delivery. The subsequent book chapters elaborate on various functional excipients such as chitosan, cyclodextrins, and Vitamin E-TPGS to attain local and systemic therapeutic action. There are book chapters focused on diverse novel carrier systems such as hydrogels, quantum dots, metal-organic framework, and prodrug approach. Additionally, book also contains chapters, exclusively dedicated to biologicals and numerical simulation in pulmonary therapeutics. The book chapters follow a sequential order, beginning with the pulmonary relevance of technology or polymeric materials, carrier synthesis schemes, current technical state-of-art, along with clinical, industrial, and regulatory aspects. Each chapter contains a future perspective section that will systematically reflect the current state of advances in pulmonary drug delivery. It also offers a practical basis for audience to understand the design and function of the delivery systems for better therapeutic outcomes. The book provides balanced views by considering the investigations from various scientific domains and industrial knowledge. Briefly, this book aims to collect, analyse, and bring together the latest developments in pulmonary drug delivery with more focus on materials and technologies. Indeed, this book is a valuable source for readers and researchers who wish to learn more about the advances in pulmonary drug delivery systems.
Author: H. Ohtaki
Publisher: John Wiley & Sons
ISBN:
Category : Science
Languages : en
Pages : 232
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Book Description
An overview of crystallization processes of organic and inorganic substances from various homogeneous liquids. Crystal structures, phase transitions and crystallization rates are described in the book in connection with the structure of ions, complexes and molecules of the solution phase.
