Smooth Muscle Cell-macrophage Interactions in Atherogenesis PDF Download
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Author: Robyn Elizabeth Rennick
Publisher:
ISBN:
Category : Atherosclerosis
Languages : en
Pages : 594
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Book Description
Author: Robyn Elizabeth Rennick
Publisher:
ISBN:
Category : Atherosclerosis
Languages : en
Pages : 594
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Book Description
Author: Jahnic Beck-Joseph
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"Cardiovascular disease is the leading cause of death worldwide, with atherosclerosis being the largest contributor towards life-threatening events. Cellular activity and cholesterol accumulation lead to vascular remodeling and the formation of fatty plaques. Complications arise from blood clots forming at ruptured or eroded plaques leading to thrombotic occlusion. Vascular smooth muscle cells and macrophages switch their phenotypes during atherosclerosis and influence the disease in various ways. Knowledge about intercellular communication is critical to understanding the disease and the development of novel medications. In this thesis, the literature has been reviewed on molecular interactions between vascular smooth muscle cells and macrophages in atherosclerosis. Communication through soluble factors, extracellular vesicles, and physical contact are discussed. Additionally, preliminary in-vitro experiments were devised in an attempt to probe transcriptional changes occurring during early phenotypic switching. To mimic early lesions, primary mouse smooth muscle cells and macrophages were co-cultured with low-density lipoproteins. Muscle cells were kept pure using transwell inserts and analyzed using qPCR. Markers associated with early phenotypic switching from a contractile to a dysfunctional cell were monitored. In future studies, cells undergoing transitioning could be subjected to next-generation sequencing for in-depth transcriptional analysis and insights into pathways involved in early phenotypic switching.At this time, there is insufficient data to statistically validate findings. However, the preliminary qPCR data shows interesting results with contractile markers generally downregulated and macrophage markers upregulated. Synergistic effects were observed for some genes, for which differential expression was only achieved with culture conditions that included both LDL and macrophages"--
Author: Allison Cherry Ostriker
Publisher:
ISBN:
Category :
Languages : en
Pages : 191
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Book Description
Author: Hiroshi Iwata
Publisher:
ISBN:
Category : Technology
Languages : en
Pages :
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Book Description
Vascular smooth muscle cells (SMCs) and monocytes/macrophages represent major players in atherosclerotic vascular diseases. In addition to physiological and pathological roles of each cell type in atherosclerosis, dynamic interplay between SMCs and monocytes/macrophages may contribute to the pathogenesis of atherosclerosis more critically than previously understood. Activated macrophages accelerate pro-atherogenic functions of SMCs in vascular lesions. Activated SMCs promote additional accumulation of pro-inflammatory macrophages through expression of chemoattractants. More recent evidence suggests the interchangeability between SMC and monocyte/macrophage lineages. Future efforts to understand such dynamic interactions between SMCs and macrophages may provide novel insight into the pathogenesis of vascular disease and the development of new classes of medical solutions.
Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589
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Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: Neville Woolf
Publisher: Butterworth-Heinemann
ISBN:
Category : Medical
Languages : en
Pages : 348
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Book Description
Author: Georg Wick
Publisher: Springer Science & Business Media
ISBN: 370910338X
Category : Medical
Languages : en
Pages : 628
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Book Description
It has been known for over 150 years that hallmarks of inflammation can be observed in the wall of atherosclerotic vessels. It was, however, not clear if this inflammation is the cause or the consequence of atherogenesis. More recently, it has become evident that inflammation mediated both by innate and adaptive immunity is instrumental even in the earliest stages of the development of atherosclerotic lesions, i.e., that it plays an important pathogenetic role. In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis.
Author: Marc A. Laberge
Publisher:
ISBN:
Category :
Languages : en
Pages : 80
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Book Description
Author: Margarethe Geiger
Publisher: Springer
ISBN: 3030122700
Category : Medical
Languages : en
Pages : 392
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Book Description
This well-structured textbook offers essential knowledge on the vascular system. The reader will learn the properties, basic cellular mechanisms and development of the different parts of the vascular system (including the heart), gain knowledge on vascular and related diseases, and will be made familiar with common and most current methods and techniques applied to analyze the vascular system in patients, in animal models, and ex vivo. This book is based on a PhD Course for students from various bioscientific backgrounds given at the Medical University of Vienna, and it will be a valuable resource for Master ́s Students in vascular biology and biomedicine in general and a helpful tool for young researchers world-wide wishing to gain or refresh their knowledge in this field.
Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
ISBN: 1615041230
Category : Science
Languages : en
Pages : 309
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Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
