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Author: Kevin Gaston
Publisher: Caister Academic Press Limited
ISBN: 9781904455998
Category : Science
Languages : en
Pages : 0
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Book Description
Small DNA tumor viruses are a fascinating group of double-stranded DNA viruses, made up of the polyomavirus, the adenovirus, and the papillomavirus families. These viruses continue to provide fundamental insights into mammalian cell transformation, cell cycle control, and tumor formation. The causal link between papillomaviruses and some human cancers is well known, and a role for polyomavirus in human cancer has recently been established. Adenoviruses do not cause cancer in humans, but, as well as providing excellent tools for the study of host cell processes, these viruses have been exploited as delivery vehicles in gene therapy for diseases, such as cystic fibrosis and cancer. A common feature of small DNA tumor viruses is their heavy reliance on the host for survival and replication. Understanding the virus-host relationship is critical to understanding the tumorigenic process and how these viruses subvert the host's immune system. In this timely book, leading scientists from around the world review current hot topics in this area, providing a fascinating overview of the molecular biology of these viruses and their interactions with the host. The topics covered include: HPV infections and the production of HPV virion stocks * viral oncoproteins and their functions * the replication and maintenance of viral genomes * virus-induced alterations in cellular miRNAs * viral deregulation of DNA damage responses * the initiation of viral DNA replication * induction of genomic instability by viral oncoproteins * targeting of PML proteins and PML nuclear bodies by these viruses * adenoviruses and gene therapy. The book will be essential reading for scientists and researchers working on small DNA tumor viruses and their associated diseases. It is also a recommended text for anyone involved with DNA replication, DNA damage responses and genome instability, virus-host interactions, and viral tumorigenesis or antiviral drug development.
Author: Kevin Gaston
Publisher: Caister Academic Press Limited
ISBN: 9781904455998
Category : Science
Languages : en
Pages : 0
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Book Description
Small DNA tumor viruses are a fascinating group of double-stranded DNA viruses, made up of the polyomavirus, the adenovirus, and the papillomavirus families. These viruses continue to provide fundamental insights into mammalian cell transformation, cell cycle control, and tumor formation. The causal link between papillomaviruses and some human cancers is well known, and a role for polyomavirus in human cancer has recently been established. Adenoviruses do not cause cancer in humans, but, as well as providing excellent tools for the study of host cell processes, these viruses have been exploited as delivery vehicles in gene therapy for diseases, such as cystic fibrosis and cancer. A common feature of small DNA tumor viruses is their heavy reliance on the host for survival and replication. Understanding the virus-host relationship is critical to understanding the tumorigenic process and how these viruses subvert the host's immune system. In this timely book, leading scientists from around the world review current hot topics in this area, providing a fascinating overview of the molecular biology of these viruses and their interactions with the host. The topics covered include: HPV infections and the production of HPV virion stocks * viral oncoproteins and their functions * the replication and maintenance of viral genomes * virus-induced alterations in cellular miRNAs * viral deregulation of DNA damage responses * the initiation of viral DNA replication * induction of genomic instability by viral oncoproteins * targeting of PML proteins and PML nuclear bodies by these viruses * adenoviruses and gene therapy. The book will be essential reading for scientists and researchers working on small DNA tumor viruses and their associated diseases. It is also a recommended text for anyone involved with DNA replication, DNA damage responses and genome instability, virus-host interactions, and viral tumorigenesis or antiviral drug development.
Author: Blossom Damania
Publisher: Springer Science & Business Media
ISBN: 0387689451
Category : Medical
Languages : en
Pages : 805
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Book Description
This unique book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. This book represents a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.
Author:
Publisher:
ISBN:
Category : Oncogenic viruses
Languages : en
Pages : 1254
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Book Description
Author: Sally Roberts
Publisher: Caister Academic Press Limited
ISBN: 9781910190791
Category : Medical
Languages : en
Pages : 0
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Book Description
Topics covered range from an overview of the contribution of DNA tumour viruses to the cancer burden worldwide, and the molecular pathogenesis of virus driven cancers to vaccine development.
Author: M. A. Epstein
Publisher: Springer Science & Business Media
ISBN: 3642672361
Category : Medical
Languages : en
Pages : 467
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Book Description
The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
Author: Ann Arvin
Publisher: Cambridge University Press
ISBN: 1139461648
Category : Medical
Languages : en
Pages : 1325
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Book Description
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author: Wang-Shick Ryu
Publisher: Academic Press
ISBN: 0128009993
Category : Science
Languages : en
Pages : 441
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Book Description
Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author’s more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. Presents viruses within their family structure Contains recommended journal articles with perspectives to put primary literature in context Includes integrated recommended reading references within each chapter Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank
Author: Jing-hsiung James Ou
Publisher: World Scientific
ISBN: 9812833463
Category : Medical
Languages : en
Pages : 354
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Book Description
Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and The cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, Epsteinndash;Barr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fellows, medical students, physicians and non-experts who are interested in learning more about the oncogenic viruses and how they cause human cancers.
Author: Samuel Schiminovich
Publisher: Springer Science & Business Media
ISBN: 1468469703
Category : Medical
Languages : en
Pages : 265
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Book Description
Milestones in Current Research is a series of reprint collections dis tinguished from other such publications by new concepts in preparation, presentation, and intent. The aim of each volume is to gather for a given field the seminal contributions that have defined and shaped the trends within the most active areas of current research. The selections for each volume and the structure of the book have been determined with the help of a novel tech nique of bibliographic analysis and have then been presented to an acknowl edged scientific authority for minor adjustments and the writing of an In troduction. These introductions will lend historic perspective to the material selected for each volume. The bibliographic analysis used tends to select papers central to the areas of current research within, roughly, the last decade and is a systematic procedure for depicting, delineating, and covering all such areas over a wide spectrum of scientific research. It is hoped that with this procedure it will be possible to achieve an objectivity, authority, and thoroughness not reached by others and that the timeliness of the volumes will not be limited to just a few years. Each volume should have the permanent value of a historical statement and yet be suf ficiently interesting to active researchers in the field as well as to students exploring the quiet way in which the relentless drama of research unfolds in the journal literature.
Author:
Publisher:
ISBN:
Category : Cells
Languages : en
Pages : 4
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Book Description
