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Author: David Ignatius Walsh (III)
Publisher:
ISBN:
Category : Microfluidic devices
Languages : en
Pages : 112
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Book Description
As the delivery of healthcare has shifted from best clinical outcomes to best value outcomes, the promise of point-of-care diagnostics provides an avenue for faster and more accurate treatment, saving both time and money than traditional laboratory diagnostic testing. For example, the lateral flow pregnancy test, has provided an at-home diagnostic test that has greatly benefited many by rapidly and cheaply detecting the presence human chorionic gonadotropin (hCG) hormone in pregnant women. The need for new point-of-care diagnostics for disease detection and treatment has provided a strong opportunity for microfluidics. Microfluidics is the interdisciplinary field studying the manipulation of fluids in "microchannels". Biomedical microfluidics has enabled the development of point-of-care diagnostic platforms that benefit from low-cost materials, small footprint, low reagent and sample volumes, and automation. However, while many microfluidic platforms have been developed, few have reached the market due to the inability to scale-up manufacturing. This dissertation contributes to the development of scalable rapid prototyping techniques to better translate microfluidic systems from the lab bench to the clinic. Chronic and idiopathic eye diseases are one facet of healthcare that could greatly benefit from microfluidic point-of-care diagnostic platforms to better preserve vision, reduce surgeries needed for large volume biopsies and personalize disease treatment. Three different scalable platforms have been developed to address this clinical need utilizing innovative microfluidic techniques such as centrifugal and paper-based flow control. These systems contribute to the field by: 1) providing a framework for scalable rapid prototyping of microfluidic devices using commercialization-friendly manufacturing methods and materials, 2) enabling the study of molecular diagnostic analysis and complicated cell functions such as chemotaxis at very small time frames (
Author: David Ignatius Walsh (III)
Publisher:
ISBN:
Category : Microfluidic devices
Languages : en
Pages : 112
Get Book Here
Book Description
As the delivery of healthcare has shifted from best clinical outcomes to best value outcomes, the promise of point-of-care diagnostics provides an avenue for faster and more accurate treatment, saving both time and money than traditional laboratory diagnostic testing. For example, the lateral flow pregnancy test, has provided an at-home diagnostic test that has greatly benefited many by rapidly and cheaply detecting the presence human chorionic gonadotropin (hCG) hormone in pregnant women. The need for new point-of-care diagnostics for disease detection and treatment has provided a strong opportunity for microfluidics. Microfluidics is the interdisciplinary field studying the manipulation of fluids in "microchannels". Biomedical microfluidics has enabled the development of point-of-care diagnostic platforms that benefit from low-cost materials, small footprint, low reagent and sample volumes, and automation. However, while many microfluidic platforms have been developed, few have reached the market due to the inability to scale-up manufacturing. This dissertation contributes to the development of scalable rapid prototyping techniques to better translate microfluidic systems from the lab bench to the clinic. Chronic and idiopathic eye diseases are one facet of healthcare that could greatly benefit from microfluidic point-of-care diagnostic platforms to better preserve vision, reduce surgeries needed for large volume biopsies and personalize disease treatment. Three different scalable platforms have been developed to address this clinical need utilizing innovative microfluidic techniques such as centrifugal and paper-based flow control. These systems contribute to the field by: 1) providing a framework for scalable rapid prototyping of microfluidic devices using commercialization-friendly manufacturing methods and materials, 2) enabling the study of molecular diagnostic analysis and complicated cell functions such as chemotaxis at very small time frames (
Author: Jonathan Pegan
Publisher:
ISBN: 9781267979568
Category :
Languages : en
Pages : 35
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Book Description
Micromachining techniques have enabled the rapid expansion of small-scale medical devices. However, as these techniques were originally developed for the integrated circuit industry, many of the processes and materials are ill suited for use in biological systems. Importantly, as current biomedical devices are larger then integrated circuits, scalability of manufacturing becomes a major challenge. There is a great need to discover new techniques and materials in the fabrication of biomedical microdevices that are inexpensive and can be easily scaled up for commercial production. Presented in this work are microfabrication techniques adapted for use with shape-memory polymers. These shape-memory polymers are less costly and more biocompatible then standard biomedical microdevice processes and materials. Notably, as these films are flexible, they are compatible with roll-to-roll manufacturing. These films are used to create a number of biomedical microdevices inexpensively with scalable fabrication processes to aid in the translation of biomedical microtechnology for point-of-care diagnostics.
Author: Jayvadan K. Patel
Publisher: Springer Nature
ISBN: 3030507033
Category : Medical
Languages : en
Pages : 611
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Book Description
This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges.
Author:
Publisher: Academic Press
ISBN: 0323853048
Category : Science
Languages : en
Pages : 370
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Book Description
Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B, Volume 187 represents the collation of chapters written by eminent scientists worldwide. Chapters in this new release include Design and fabrication of microfluidics devices for molecular biology applications, Micro/Nanofluidics devices for drug delivery, From organ-on-chip to body-on-chip: the next generation of microfluidics platforms for in vitro drug toxicity testing, Micro/Nanofluidics for high throughput drug screening, Design, fabrication and assembly of lab-on-a-chip and its uses, Advances in microfluidic 3D cell culture for pre-clinical drug development, Tissue and organ culture on lab-on-a chip for biomedical applications, and much more. - Offers a basic understanding of the state-of-the-art design and fabrication of microfluidics/ nanofluidics and lab on chip - Explains how to develop microfluidics/nanofluidic for advanced application such as healthcare, high throughout drug screening, 3D cell culture and organ-on-chip - Discusses the emerging demands and research of micro/nanofluidic based devices in biomedical and translational research applications
Author: Dimitrios A. Lamprou
Publisher: Springer Nature
ISBN: 3031607171
Category :
Languages : en
Pages : 494
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Book Description
Author: Xiujun James Li
Publisher: Woodhead Publishing
ISBN: 9780857096975
Category : Technology & Engineering
Languages : en
Pages : 0
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Book Description
Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications. The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.
Author: Sameer Sudhakar Tendulkar
Publisher:
ISBN:
Category :
Languages : en
Pages : 151
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Book Description
Author: Francis E. H. Tay
Publisher: Springer
ISBN: 9781441953162
Category : Technology & Engineering
Languages : en
Pages : 336
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Book Description
Microfluidics and BioMEMS Applications central idea is on microfluidics, a relatively new research field which finds its niche in biomedical devices, especially on lab-on-a-chip and related products. Being the essential component in providing driving fluidic flows, an example of micropump is chosen to illustrate a complete cycle in development of microfluidic devices which include literature review, designing and modelling, fabrication and testing. A few articles are included to demonstrate the idea of tackling this research problem, and they cover the main development scope discussed earlier as well as other advanced modelling schemes for microfluidics and beyond. Scientists and students working in the areas of MEMS and microfluidics will benefit from this book, which may serve both communities as both a reference monograph and a textbook for courses in numerical simulation, and design and development of microfluidic devices.
Author: Philip Wing-Jung Hum
Publisher:
ISBN:
Category :
Languages : en
Pages : 112
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Book Description
Discussion of the current manufacturing process of polydimethylsiloxane (PDMS) parts and the emergence of PDMS use in biomedical microfluidic devices addresses the need to develop large scale manufacturing processes for the fabrication of said devices. Casting PDMS parts is found to be the best mass production process after evaluating several different production methods. Automation of the manufacturing process is introduced as a solution to the need for mass production. Changing variables within the production process and its effects are also discussed with the recommendation being made for using low viscosity pre-cured PDMS, high temperature curing and high vacuum degassing techniques to produce high quality parts at high production rates. The further development of producing two-sided PDMS parts is recommended by investigating the usage of a non-closed aspect limited casting process.
Author: Raju Khan
Publisher: CRC Press
ISBN: 1000548376
Category : Medical
Languages : en
Pages : 416
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Book Description
This book provides a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. This authors examine microfluidics based diagnosis in the biomedical field as an upcoming field with extensive applications. It provides a unique approach and comprehensive technology overview for diagnosis management towards early stages of various bioanalytes via cancer diagnostics diabetes, alzheimer disease, toxicity in food products, brain and retinal diseases, cardiovascular diseases, and bacterial infections etc. Thus, this book would encompass a combinatorial approach of medical science, engineering and biomedical technology. The authors provide a well-focused and comprehensive overview of novel technologies involved in advanced microfluidics based diagnosis via various types of prognostic and diagnostic biomarkers. Moreover, this book contains detailed description on the diagnosis of novel techniques. This book would serve as a guide for students, scientists, researchers, and microfluidics based point of care technologies via smart diagnostics and to plan future research in this valuable field.
