Author: Mona Dagar
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659193149
Category :
Languages : en
Pages : 88
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Book Description
Periodontitis is an inflammatory condition of the supporting tissues of the teeth. Intracellular enzymes are increasingly released from the damaged cells of periodontal tissues into the gingival crevicular fluid and saliva. It has been a great challenge to determine biomarkers for screening and predicting the early onset of disease (prognostic tests) or evaluating the disease activity and the efficacy of therapy.Various enzymes evaluated for the early diagnosis of periodontal disease are aspartate and alanine aminotransferases ( AST, ALT ), lactate dehydrogenase ( LDH ), creatine kinase ( CK ), alkaline and acid phosphatase ( ALP, ACP ) and gamma glutamiltransferase ( GGT ), myeloperoxidase ( MPO ). The activities of CK, LDH, AST, ALT, GGT, ALP, ACP, MPO, enzymes are found to be increased in periodontal diseases. Thus, an attempt has been made to review the diagnostic value of salivary enzymes in the diagnosis and progression of periodontal disease.
Author: Ulvi Kahraman Gürsoy
Publisher: Frontiers Media SA
ISBN: 2889451240
Category :
Languages : en
Pages : 107
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Book Description
Periodontitis is an infection-induced inflammatory disease of the tooth supporting tissues. Treatment of periodontal diseases and regeneration of the effected tissues can be possible only in the early diagnosis of the disease. If left undiagnosed or untreated, periodontitis leads to irreversible soft and hard tissue destruction and finally to tooth loss. Saliva is known to contain inflammatory mediators, host tissue and cell degradation products as well as microbial metabolites and enzymes, reflecting the health status of the oral cavity. In this topic, in collaboration with the well-known scientists working on the field of salivary diagnostics, we demonstrate evidence on monitoring periodontitis by salivary analysis.
Author: Gazal Jain
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659685866
Category :
Languages : en
Pages : 84
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Book Description
Periodontal disease is a chronic bacterial infection characterized by persistent inflammation, connective tissue breakdown and alveolar bone destruction. Clinical parameters and indices and radiographic assessment of alveolar bone loss provide information on the severity of periodontitis but they do not measure disease activity. Thus the use of salivary biomarkers, could provide more accurate and allow more reliable evaluation of periodontal disease state. Saliva is an easily available, non-invasive diagnostic medium for a rapidly widening range of diseases and clinical situations. Salivary constituents that have been studied as potential diagnostic biomarkers for periodontal disease mainly include locally produced proteins of host and bacterial origin (enzymes, immunoglobulins and cytokines), genetic/genomic biomarkers such as DNA and mRNA of host origin, bacteria and bacterial products, ions, steroid hormones and volatile compounds.
Author: David Wong
Publisher: Wiley-Blackwell
ISBN:
Category : Medical
Languages : en
Pages : 330
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Book Description
'Salivary Diagnostics' describes the nature of saliva and the basis for its usefulness as a diagnostic fluid. It then surveys and reviews the field of research, moving on to detail the development of technologies and the deciphering of the human salivary proteome.
Author: Tonnie Kituku Mulli
Publisher:
ISBN:
Category : Biochemical markers
Languages : en
Pages : 544
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Book Description
Introduction: The aim of the study was to investigate novel biomarkers of periodontal disease present in GCF and saliva. -- Methods: The identities of specific putative biomarkers identified by SELDI-TOF MS were confirmed using 1-D PAGE coupled with LC-MS/MS. These biomarkers were then tested using ELISA in the samples that had been initially screened using SELDI-TOF MS as well as in saliva samples in an independent cohort selected according to diabetic status rather than periodontal status. The effect of non-surgical periodontal therapy, diabetes, saliva sample collection method, eating, time of day, day of the week and storage conditions on the salivary concentration of human neutrophil peptide 1-3 (HNP 1-3), cathelicidin LL-37 and protein S100A8 were tested. Copy number variation for HNP 1-3 gene, DEFA1A3 was tested in an independent cohort and the data analysed for association with presence and degree of periodontal disease. -- Results: Antimicrobial peptides, HNP 1-3, LL-37 and S100A8 were identified. GCF and salivary HNP 1-3 and LL-37 concentrations were significantly elevated in periodontitis than in gingivitis or health. LL-37 was significantly elevated in aggressive periodontitis (AgP) compared with chronic periodontitis (CP) and gingivitis/health. Periodontal therapy reduced the salivary levels of HNP 1-3. Diabetes, eating and day of week had no significant effect on AMP levels. Saliva collection using spitting method yielded significantly more AMPs than using Salivettes®. Sample collection at 16:00 hours yielded significantly higher amounts of AMPs than samples collected at other times. Sample storage at room temperature (RT) for up to 48 hours had no significant impact on the salivary HNP 1-3 and LL-37 concentration while a proteinase inhibitor did not did improve the recovery of the AMPs after 72 hours.
Author: Charles F. Streckfus
Publisher: Springer
ISBN: 3662453991
Category : Medical
Languages : en
Pages : 213
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Book Description
This book reviews the progress made in salivary diagnostics during the past two decades and identifies the likely direction of future endeavors. After an introductory section describing the histological and anatomical features of the salivary glands and salivary function, salivary collection devices and diagnostic platforms are reviewed. The field of “salivaomics” is then considered in detail, covering, for example, proteomics, the peptidome, DNA and RNA analysis, biomarkers, and methods for biomarker discovery. Salivary diagnostics for oral and systemic diseases are thoroughly discussed, and the role of salivary gland tissue engineering for future diagnostics is explored. The book closes by considering legal issues and barriers to salivary diagnostic development. Advances in Salivary Diagnostics will be an informative and stimulating reference for both practitioners and students.
Author: Nurcan Buduneli
Publisher: Springer Nature
ISBN: 3030373177
Category : Medical
Languages : en
Pages : 90
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Book Description
This book examines all aspects of the progress being made towards the development of highly specific and sensitive biomarkers that will overcome the shortcomings of clinical assessments in periodontics. The opening chapters present the basic anatomic features of periodontal tissues, outline the nature and pathogenic mechanisms of periodontal diseases, and discuss both conventional and novel methods of diagnosis with reference to their specificity and sensitivity. The potential role of biomarkers in periodontal diagnosis is then presented in the light of the published data. The biological samples in which potential biomarkers are sought are evaluated comparatively, drawing attention to their strengths and weaknesses, and the available technologies for biomarker studies are reviewed. The potential benefits of biomarkers are also discussed with regard to the possible bidirectional interactions between periodontal diseases and systemic health. Finally, the past, present, and future of periodontics are examined from a broader perspective. Readers will find the book to be an ideal summary of the state of the art in the field as biomarkers emerge that promise to facilitate periodontal diagnostics and permit timely, personally tailored interventions.
Author:
Publisher: BoD – Books on Demand
ISBN: 1789844606
Category : Medical
Languages : en
Pages : 100
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Book Description
This book aims to provide readers with the latest updates and an informative overview of the most successful diagnostic aids for periodontal diseases. This book is divided into three sections. Section 1 discusses the periodontal disease pathogenesis and how the disease develops and the contributing factors in disease development. Section 2 includes three chapters that focus mainly on the most common and recent biomarkers that aid in diagnosis of periodontal diseases. Section 3 includes one chapter and discusses a non-surgical treatment modality that could provide definite improvement in the mild to moderate conditions in periodontal diseases.
Author: Victor R. Preedy
Publisher: Springer
ISBN: 9789400776951
Category : Medical
Languages : en
Pages : 0
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Book Description
In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics and so on. The chapters are written by national or international experts and specialists.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Periodontitis is an infection-induced inflammatory disease of the tooth supporting tissues. Treatment of periodontal diseases and regeneration of the effected tissues can be possible only in the early diagnosis of the disease. If left undiagnosed or untreated, periodontitis leads to irreversible soft and hard tissue destruction and finally to tooth loss. Saliva is known to contain inflammatory mediators, host tissue and cell degradation products as well as microbial metabolites and enzymes, reflecting the health status of the oral cavity. In this topic, in collaboration with the well-known scientists working on the field of salivary diagnostics, we demonstrate evidence on monitoring periodontitis by salivary analysis.
