Role of REM Sleep, Melanin Concentrating Hormone and Orexin/hypocretin Systems in Ischemic Stroke PDF Download
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Author: Marta Pace
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Marta Pace
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: S. R. Pandi-Perumal
Publisher: Springer
ISBN: 3319757652
Category : Science
Languages : en
Pages : 236
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Book Description
This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists.
Author: Sebastiaan Overeem
Publisher: John Wiley & Sons
ISBN: 1118777263
Category : Medical
Languages : en
Pages : 372
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Book Description
The acclaimed guide to quickly and confidently diagnosing and treating sleep disorders in neurological disease—now with more algorithms and tables The diagnosis and treatment of sleep disorders can be extremely challenging for physicians, especially when there is underlying neurological disease. In addition to the primary sleep disorders, there is a growing clinical interest in sleep disturbances associated with common neurological disorders such as Parkinson's disease. This updated and expanded edition of the critically acclaimed Sleep Disorders in Neurology: A Practical Approach provides doctors with expert recommendations and clear guidance on identifying sleep disorders in patients suffering from neurological diseases and providing effective treatment plans. In creating this Second Edition doctors Overeem and Reading made every effort to further enhance the practical approach of the first edition by adding additional algorithms and tables to assist physicians in more rapid decision making. In addition, they expanded the content to include greater coverage of primary sleep disorders. Classification and diagnosis chapters have been revamped to follow the 3rd International Classification of Sleep Disorders. Offers physicians, with a practical approach to diagnosing and treating complex sleep disorders Draws on the expertise of neurologists who specialize in the disorders under discussion Features quick-access algorithms that help physicians rapidly diagnose and treat primary and secondary sleep disorders with confidence Provides guidance on when to consult a sleep specialist in managing a particular sleep disorder and Written by a multinational author team who provide a wider perspective and range of clinical experience Sleep Disorders in Neurology: A Practical Approach, Second Edition is an essential resource for sleep medicine specialists, as well as clinicians and health care professionals not specifically trained in sleep medicine, but who nevertheless need to manage neurologically damaged patients with increasingly recognized sleep/wake disturbances.
Author: Lourdes M. DelRosso
Publisher: Springer Nature
ISBN: 3030543595
Category : Medical
Languages : en
Pages : 309
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Book Description
This practical text provides knowledge of the basic neuroscience of sleep and sleep disorders as they interrelate with various neurologic conditions. Chapters in the first section cover neural networks involved in normal sleep processes, including dreams and memory. Also discussed are how these neural networks interact in various sleep stages and sleep disorders, such as sleep related movement disorders. The book's second section explores the pathophysiology of sleep disorders in the spectrum of neurologic conditions in both adults and children. This includes sleep changes in patients with dementia, seizures, headaches, and stroke, and other common neurologic disorders. Sleep Neurology fills an important gap in the sleep medicine literature by providing the underpinnings of sleep disorders and will be of great value to students, residents, and clinicians.
Author: Sebastiaan Overeem
Publisher: John Wiley & Sons
ISBN: 9781444315165
Category : Health & Fitness
Languages : en
Pages : 344
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Book Description
Formulate treatment plans with confidence when you consult SleepDisorders in Neurology, a helpful overview of both common andrare neurological disorders that are frequently accompanied bysignificant sleep disturbances. This concise guide explains when toconsult a sleep specialist in managing a particular sleep disorderand draws on the expertise of neurologists who specialize in thedisorders under discussion. This practical guide is fullyillustrated and easily digested, providing a counterpoint to largeencyclopedic reference volumes. The authors take you from historytaking and diagnostic testing, to pharmacological andnon-pharmacological treatment options, and are joined by diseasesub-specialists in the chapters on disease specific sleepdisturbances and the effects of common neurological medications onsleep. This book is essential for sleep medicine specialists, as wellas for clinicians and health care professionals not specificallytrained in sleep medicine, but who nevertheless need to manageneurologically damaged patients with increasingly recognizedsleep-wake disturbances.
Author: Luis De Lecea
Publisher: Springer Science & Business Media
ISBN: 0387254463
Category : Medical
Languages : en
Pages : 438
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Book Description
The first report that rapid eye movements occur in sleep in humans was published in 1953. The research journey from this point to the realization that sleep consists of two entirely independent states of being (eventually labeled REM sleep and non-REM sleep) was convoluted, but by 1960 the fundamental duality of sleep was well established including the description of REM sleep in cats associated with “wide awake” EEG patterns and EMG suppression. The first report linking REM sleep to a pathology occurred in 1961 and a clear association of sleep onset REM periods, cataplexy, hypnagogic hallucinations and sleep paralysis was fully established by 1966. When a naïve individual happens to observe a full-blown cataplexy attack, it is both dramatic and unnerving. Usually the observer assumes that the loss of muscle tone represents syncope or seizure. In order to educate health professionals and the general public, Christian Guilleminault and I made movies of full-blown cataplectic episodes (not an easy task). We showed these movies of cataplexy attacks to a number of professional audiences, and were eventually rewarded with the report of a similar abrupt loss of muscle tone in a dog. We were able to bring the dog to Stanford University and with this as the trigger, we were able to develop the Stanford Canine Narcolepsy Colony. Breeding studies revealed the genetic determinants of canine narcolepsy, an autosomal recessive gene we termed canarc1. Emmanuel Mignot took over the colony in 1986 and began sequencing DNA, finally isolating canarc1 in 1999.
Author: Daniel Pedro Cardinali
Publisher: Springer
ISBN: 3319575716
Category : Medical
Languages : en
Pages : 393
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Book Description
A traditional view of the Autonomic Nervous System (ANS) considers only its peripheral part: the sympathetic and parasympathetic systems. However, this view misses to consider the most important ANS function: the maintenance of homeostasis. This term is used today to define not only the strategies that allow the body proper response to changes in the environment (reactive homeostasis), but also temporal mechanisms that allow the body to predict the most likely timing of environmental stimuli (predictive homeostasis based on biological rhythms). This book discusses the ANS from both an enlarged and a timed perspective. First, it presents how the organization of the ANS is hierarchical into different levels. Following that, the book discusses how the ANS changes functionally in the three-body configurations (wakefulness, slow sleep, rapid eye movement sleep) found in a 24-hour cycle. Finally, the most important clinical implications of this enlarged and timed vision of ANS will be discussed. Autonomic Nervous System – Basic and Clinical Aspects is a comprehensive text intended for medical students and health professionals who are interested in a deeper approach to this important part of the nervous system. It provides a detailed and complete understanding of the neuroscience behind the ANS, allowing a proper clinical applicability of this knowledge.
Author: Jim R. Fadel
Publisher: Academic Press
ISBN: 0128137525
Category : Science
Languages : en
Pages : 190
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Book Description
The Orexins/Hypocretins System: Functional Roles and Therapeutic Potential summarizes research on both the physiological functioning of orexins, their impact on homeostatic processes, and related disorders. The book encompasses the effects on appetite, sleep, substance abuse, cognition, and anxiety. Additionally, it examines new therapeutic approaches utilizing orexins, including utilization of orexin receptors for drug development. It is essential reading for neuroscience researchers interested in brain-behavior relationships, as well as psychiatrists, endocrinologists and pharmacologists. - Provides an overview of new research on orexins/hypocretins - Includes an overview of intracellular signaling and orexin physiology - Discusses the effects on arousal, appetite, cognition, addiction and anxiety - Examines orexin based therapies and their potential use in disorders - Explores orexin receptors for drug development
Author: Jian-Sheng Lin
Publisher: Frontiers Media SA
ISBN: 2889194345
Category : Brain
Languages : en
Pages : 100
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Book Description
Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.
Author: MallIck/Inoue
Publisher: CRC Press
ISBN: 9780824703226
Category : Science
Languages : en
Pages : 450
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Book Description
This reference also includes nine color plates. Written by leading international scientists in the field, this comprehensive and up-to-date reference provides detailed coverage of various aspects of rapid eye movement sleep (REMS)-including phylogeny and evolution, ontogeny, neurophysiological and neurochemical phenomena, molecular processes, behavioral and physiological changes due to deprivation, and hypotheses on the neurodynamics of REMS. Examining the relationship between the neocortex in mammals and birds in the evolution of REM sleep, Rapid Eye Movement Sleep considers the roles of REMS in the maturation of the brain reveals a new theory that challenges the assumption that REM is solely initiated by bulbar mechanisms in intact animals explores experimental studies of REMS atonia and the mechanisms underlying tonic and phasic muscle atonia describes the cellular and molecular mechanisms and function of pontine ponto-geniculo-occipatal waves during REMS details the role of nitric oxide in the regulation of REMS summarizes new evidence on which neurotransmitters are responsible for the REMS generating mechanism presents an overview of several endogenous sleep substances that may positively or negatively regulate REMS and more. Rapid Eye Movement Sleep serves as essential reading for all researchers and clinicians in the study of sleep science, particularly physiologists and biologists; neurologists, neuropsychiatrists, psychiatrists, and psychologists; anesethiologists; and pharmacologists.
