Research and Development of Pharmaceutical Products for Neglected Diseases PDF Download
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Author: Beatrice Stirner
Publisher:
ISBN: 9782940400218
Category : Drugs
Languages : en
Pages : 274
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Book Description
Author: Beatrice Stirner
Publisher:
ISBN: 9782940400218
Category : Drugs
Languages : en
Pages : 274
Get Book Here
Book Description
Author: Frank Müller-Langer
Publisher: Springer Science & Business Media
ISBN: 3834983233
Category : Business & Economics
Languages : en
Pages : 312
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Book Description
Virtually no research is targeted at developing medicines for tropical diseases as the expected market returns from R&D into these diseases in the private pharmaceuticals sector are too low. Frank Müller-Langer addresses the market failure with respect to R&D for medicines for tropical diseases and the lack of short-term access to affordable medicines in poor countries. The author analyzes additional push and pull mechanisms to stimulate R&D for pharmaceutical products alongside patent protection which may help mitigate the problem of those consumers in poor countries who lack access to affordable medicines. Furthermore, he reasons that a global regime of banning parallel trade from low-income countries to high-income countries is desirable from a developing country’s perspective.
Author: Michael Kremer
Publisher: Princeton University Press
ISBN: 0691171165
Category : Business & Economics
Languages : en
Pages : 167
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Book Description
From Nobel Prize–winning economist Michael Kremer and fellow leading development economist Rachel Glennerster, an innovative solution for providing vaccines in poor countries Millions of people in the third world die from diseases that are rare in the first world—diseases like malaria, tuberculosis, and schistosomiasis. AIDS, which is now usually treated in rich countries, still ravages the world's poor. Vaccines offer the best hope for controlling these diseases and could dramatically improve health in poor countries. But developers have little incentive to undertake the costly and risky research needed to develop vaccines. This is partly because the potential consumers are poor, but also because governments drive down prices. In Strong Medicine, Michael Kremer and Rachel Glennerster offer an innovative yet simple solution to this worldwide problem: "Pull" programs to stimulate research. Here's how such programs would work. Funding agencies would commit to purchase viable vaccines if and when they were developed. This would create the incentives for vaccine developers to produce usable products for these neglected diseases. Private firms, rather than funding agencies, would pick which research strategies to pursue. After purchasing the vaccine, funders could distribute it at little or no cost to the afflicted countries. Strong Medicine details just how these legally binding commitments would work. Ultimately, if no vaccines were developed, such a commitment would cost nothing. But if vaccines were developed, the program would save millions of lives and would be among the world's most cost-effective health interventions.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309178169
Category : Medical
Languages : en
Pages : 151
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Book Description
The process for developing new drug and biologic products is extraordinarily expensive and time-consuming. Although large pharmaceutical companies may be able to afford the cost of development because they can expect a large return on investment, organizations developing drugs to treat rare and neglected diseases are unable to rely on such returns. On June 23, 2008, the Institute of Medicine's Forum on Drug Discovery, Development, and Translation held a public workshop, "Breakthrough Business Models: Drug Development for Rare and Neglected Diseases and Individualized Therapies," which sought to explore new and innovative strategies for developing drugs for rare and neglected diseases.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309158060
Category : Medical
Languages : en
Pages : 442
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Book Description
Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.
Author: Bjørn Lomborg
Publisher: Cambridge University Press
ISBN: 1107028698
Category : Health & Fitness
Languages : en
Pages : 387
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Book Description
A timely thought-provoking book, which examines the first-ever comparative cost-benefit analysis of responses to HIV/AIDS in Africa.
Author: Goutam Brahmachari
Publisher: Elsevier
ISBN: 0128157240
Category : Science
Languages : en
Pages : 461
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Book Description
Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. - Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery - Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases - Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases
Author: Jorge Lima de Magalhães
Publisher:
ISBN: 9788561325732
Category : Medicine
Languages : en
Pages : 272
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Book Description
Esta obra resulta de uma pesquisa da evolução da saúde pública brasileira e do respectivo status do mercado farmacêutico, das Parcerias Público-Privada concernente as Parcerias para Desenvolvimento de Produto. Aborda a questão da saúde pública no que concerne a epidemiologia, demonstrando a evolução das ações governamentais, explicando a questão de seis doenças negligenciadas (doença de Chagas, Dengue, Hanseníase, Leishmaniose, Malária e Tuberculose). É abordada a dinâmica do mercado farmacêutico, demonstrando o cenário mercadológico dessas seis doenças negligenciadas, no que tange os Insumos Farmacêuticos Ativos envolvidos, os medicamentos formulados, os produtores nacionais e internacionais. Também é feito um recorte das competências existentes para inovar, bem como as tendências tecnológicas para enfrentar esse agravo. Concernente às competências identificadas, entende-se por especialistas no país, os centros de pesquisa, Universidades e empresas atuantes no tema, bem como o situacional dos Estados com maiores e menores concentrações e as redes para enfrentamento do problema. Os autores fazem um overview do cenário internacional no que tange aos temas tratados no livro, identificando os cientistas e as Instituições no mundo que se destacam em cada doença negligenciada abordada no livro.
Author: David C. Swinney
Publisher: John Wiley & Sons
ISBN: 3527343040
Category : Medical
Languages : en
Pages : 392
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Book Description
A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.
Author: Danieli Arbex
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
This paper contributes to a better understanding of the pharmaceutical market for neglected diseases and propose a program that creates incentives and encourage research and development of new medicines for neglected diseases. The current patent system ensures that incentives are directed towards generating products that people want. However, the patent system has failed to create incentives to produce products for which there is a social need but no economic demand, such as drugs for diseases that primarily affect populations with little purchasing power. This paper investigates why it is occurring and shows the impact of this problem worldwide. It reviews several proposed reforms to encourage the research and development of new drugs for neglected diseases. Getting developing countries involved in the research process turns out to be critical not only for the pharmaceutical industry but also for poor and developing countries. This is a key feature of the proposed Double Push-and-Pull program, which proposes to, systematically, reorganize some of the ideas to spur innovation by involving effectively the developing countries in the process of research and development of new drugs for neglected diseases, since they are the most affected by them. The main goal of this program is to find a connection between global decisions, policies and local people's priorities regarding neglected diseases. It is a program that makes possible a link between local needs, reality on low-income countries and global assistance.
