Regulation of P2Y2 Nucleotide Receptor Expression in Salivary Glands PDF Download
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Author: Jae Suk Ahn
Publisher:
ISBN:
Category :
Languages : en
Pages : 260
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Author: Jae Suk Ahn
Publisher:
ISBN:
Category :
Languages : en
Pages : 260
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Author: Ann Marie Schrader-Ratchford
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages :
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Sjögren's syndrome (SS) is an autoimmune disease that specifically targets exocrine glands, including salivary glands, and results in an impairment of secretory function. P2Y2 nucleotide receptors for extracellular ATP and UTP are up-regulated in response to stress or injury in a variety of tissues including submandibular glands (SMGs). Therefore, our objective was to assess whether P2Y2 receptor expression is up-regulated in SMGs of the NOD. B10 mouse model of SS, and to determine the function of P2Y2Rs in salivary gland tissue. Our data indicate that P2Y2Rs are up-regulated in SMGs of the NOD. B10 mice, and this up-regulation increases as the disease progresses. Moreover, data obtained using a human submandibular gland cell line, demonstrate that P2Y2Rs activate a signaling pathway leading to gene transcription via at least two distinct mechanisms. These findings suggest that regulation of P2Y2Rs is likely to be an important therapeutic target for various diseases.
Author: Linda Ann Neighbors Landon
Publisher:
ISBN:
Category : Adenosine triphosphate
Languages : en
Pages : 202
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Author: Farid G. El-Sayed
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages :
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Author: John T. Turner
Publisher: Springer Science & Business Media
ISBN: 1461218004
Category : Science
Languages : en
Pages : 439
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Book Description
A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.
Author: Margherita Sisto
Publisher: MDPI
ISBN: 3036502726
Category : Medical
Languages : en
Pages : 314
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Book Description
A large number of diseases affect salivary gland (SG) secretion through different mechanisms, leading to SG dysfunction and associated oral problems. The glands may suffer from viral, bacterial, and, albeit rarely, fungal infections, which may cause painful swelling or obstruction; they could also become the target of an autoimmune attack or may be affected by various benign and malignant tumors which consist of a heterogeneous group of lesions with complex clinical–pathological characteristics. The loss of normal SG function results in widespread deterioration of oral health. This book, entitled “Diseases of Salivary Glands”, provides an overview of recent advances in the field of SG disorders, focusing on the cellular and molecular mechanisms involved in the pathogenesis of SG diseases and on the most innovative investigation techniques that could help to preserve patients’ health, function, and quality of life.
Author: P. Illes
Publisher: Elsevier
ISBN: 0080862454
Category : Medical
Languages : en
Pages : 449
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Book Description
The study of purinergic mechanisms has for long been focused on the actions of the nucleoside adenosine, whereby the contribution of nucleotides to the signaling systems has been underestimated.Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, this book offers a comprehensive update and overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metabolizing ecto-enzymes as well as the physiological functions of nucleotides in the nervous system. The physiology and molecular biology of receptors for ATP and other nucleotides are examined, as are the physiology and molecular biology of enzymes that hydrolyze extracellular nucleotides.At present, a pharmacology of the nucleotide signaling system is being developed. Of particular interest is the production of receptor subtype-specific antagonists and of drugs that selectively affect the extracellular lifetime of the nucleotide.An excellent source of reference for institutes of pharmacology, biochemistry, neurology, zoology, and physiology, and for the pharmaceutical industry.
Author: Rosa Gomez-Villafuertes
Publisher: Frontiers Media SA
ISBN: 2889639649
Category :
Languages : en
Pages : 126
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Author:
Publisher: Academic Press
ISBN: 012818728X
Category : Science
Languages : en
Pages : 3420
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Book Description
Encyclopedia of Gastroenterology, Second Edition provides a comprehensive and concise reference on all aspects of gastroenterology and hepatology, including the organs in the gastrointestinal system, their functions in health and disease, and strategies or procedures to resolve or prevent problems and disease. This concise, up-to-date information includes comprehensive sections on the impact of nutrition, gastrointestinal microbiota, lifestyle, commonly used drugs, and surgical procedures on health and disease. Since the first edition, attention to the roles of nutrition and gastrointestinal microorganisms (microbiota, formerly Microbiota) in health and disease has skyrocketed. In addition, an entirely new section on obesity and diabetes is included. Presents comprehensive coverage of every topic within gastroenterology Offers researchers a one-stop, fully-referenced resource to explore questions Includes teaching tools, multimedia and interactive elements Provides readers with multi-layered content and a media-rich learning resource for both instructors and students Covers hot new topics in GI health and disease, including new sections on stem cells, intestinal bacteria, obesity and intestinal microbiota
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 146
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