Regulation of Gene Expression by Metal Ions in Bacillus Subtilis PDF Download
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Author: Lei Chen
Publisher:
ISBN:
Category :
Languages : en
Pages : 478
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Author: Lei Chen
Publisher:
ISBN:
Category :
Languages : en
Pages : 478
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Book Description
Author: Simon Silver
Publisher: Springer Science & Business Media
ISBN: 1461559936
Category : Science
Languages : en
Pages : 479
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Book Description
This is the first volume on the role of metal ions in regulating genes to focus not only on toxicity effects of metals but also on the role of metal ions in normal metabolisms, in both prokaryotes and in eukaryotes. This book is a comprehensive treatment of the role of metal ions in gene regulation, and it will be of great utility for those doing basic biological and biomedical research.
Author: Gunther Louis Eichhorn
Publisher:
ISBN: 9780444015402
Category : Biochemistry
Languages : en
Pages : 280
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Author: Paola Randazzo
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
The present doctoral thesis concerns the study of the regulatory network linked tometal ions homeostasis in the Gram+ Bacillus subtilis. Metal ions such as Fe(II), Mn(II) andZn(II) are essential for many metabolic processes, since they function as enzyme cofactors andstructural ligands of proteins. Changes in ions availability can alter activity of enzymes of thecarbon metabolism and lead to changes in gene expression. In addition, the modulation of metalion homeostasis is intimately linked with the oxidative stress response: during aerobic growth,hydrogen peroxide is generated and it rapidly reacts with ferrous iron to form ROS molecules.Hence, regulation of metal ions uptake/efflux has to be finely regulated and coordinated with othercellular processes. With the present project, I aim to understand at system's level how Bacillussubtilis integrates the control of metal ions homeostasis with other metabolic processes.
Author: A. L. Sonenshein
Publisher:
ISBN:
Category : Bacillus subtilis
Languages : en
Pages : 664
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Book Description
Focusing on issues of gene organization, regulation, and evolution in the context of the whole life of the cell, this new volume complements the editors' classic 1993 volume Bacillus subtilis and Other Gram-Positive Bacteria. Building upon the previous edition, Bacillus subtilis and Its Closest Relatives contains an updated annotation of the complete B. subtilis genome and includes a unique compilation of major pathways of metabolism and macromolecular synthesis, correlating genes and proteins and assigning new functions to many genes. It also provides clear explanations of the major regulatory mechanisms that are unique to gram-positive bacteria as well as an overview of their special properties. This essential reference offers detailed, current information and is valuable reading for microbiologists, biotechnologists, and students.
Author: Qiang Que
Publisher:
ISBN:
Category :
Languages : en
Pages : 354
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Book Description
Author: Frans J. de Bruijn
Publisher: John Wiley & Sons
ISBN: 1119004896
Category : Science
Languages : en
Pages : 1472
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Book Description
Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.
Author: Valeria Culotta
Publisher: John Wiley & Sons
ISBN: 1118636864
Category : Science
Languages : en
Pages : 608
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Book Description
Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.
Author: Jose M. Arguello
Publisher: Academic Press
ISBN: 0123943906
Category : Science
Languages : en
Pages : 478
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Book Description
This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
Author: Christopher A. Mendello
Publisher:
ISBN:
Category :
Languages : en
Pages : 60
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Book Description
