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Author: Gustavo Duque
Publisher: Springer Nature
ISBN: 3030258904
Category : Science
Languages : en
Pages : 382
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Book Description
This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.
Author: Gustavo Duque
Publisher: Springer Nature
ISBN: 3030258904
Category : Science
Languages : en
Pages : 382
Get Book Here
Book Description
This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.
Author: Bagher Larijani
Publisher: Frontiers Media SA
ISBN: 2889761622
Category : Medical
Languages : en
Pages : 123
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Book Description
Author: Gustavo Duque
Publisher: Elsevier
ISBN: 0128204206
Category : Reference
Languages : en
Pages : 350
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Book Description
Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity. - Presents diagnostic and therapeutic tips that facilitate the design and implementation of new care pathways, impacting the wellbeing of our older population - Provides cross-disciplinary understanding by experts from the bone/osteoporosis field and the muscle/sarcopenia field - Covers muscle and bone biology, mesenchymal stem cells, age-related changes and cross-talk between muscle, fat and bone, falls and fracture risk, glucose metabolism, diagnosis, imaging, and genetics of osteosarcopenia
Author: Bagher Larijani
Publisher: Frontiers Media SA
ISBN: 2832542328
Category : Medical
Languages : en
Pages : 110
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Book Description
This Research Topic is the second volume of the Community Series, Reducing the Burden of Age-related Disease in relation to Osteoporosis, Sarcopenia and Osteosarcopenia. Please find the first Edition here. Osteoporosis is a common disease worldwide, resulting in nearly 9 million bone fractures globally per year. The number of people living with osteoporosis is set to dramatically increase in the coming decades, because of aging populations and lifestyle changes. Developing countries suffer more from osteoporosis due to limited availability of resources. Osteoporotic fractures are one of the most prevalent causes of disability and 1/3 women and 1/5 men >50 years will experience an osteoporotic fracture. Worldwide, 40% of osteoporotic fractures occur in people of working age. In women over 45 years of age, osteoporosis accounts for more days of hospitalization than diabetes, heart attacks or breast cancer. Fractures are also directly responsible for a 30% increase in mortality in the first year after the incidence. While the underlying cause of fragility fracture is osteoporosis, and a previous fracture increases the risk of the following fracture by nearly twofold in men and women, only 9%–50% of patients with fragility fractures have formal bone health assessment and treatments. According to a systematic review, bone density scans were ordered only for 1 to 32% of adults who experience a fragility fracture. Furthermore, post-hip fracture mortality rates vary between 25-30% in western countries, and 2-3 folds higher in populations from the Middle East and Africa region. Sarcopenia is a syndrome defined by loss of skeletal muscle mass and strength that gradually progresses by age and it is severely correlated with poor quality of life, dependency, and mortality. Documents showed that loss of muscle mass is associated with a higher duration of hospitalization and costs. The direct health care cost attributed to sarcopenia in U.S.A was estimated at $18.5 billion for the year 2000 (~ 1.5% of the total healthcare expenditure). The progressive loss in bone mineral density, muscle mass and strength are significant features of the aging process and the economic burden seems to significantly increase by the worldwide population aging. Osteosarcopenia, defined by the presence of sarcopenia and bone loss, can lead to higher clinical outcomes such as falls and fractures, while the information regarding this progressively increased geriatric syndrome is scarce. Despite the preventable nature of osteoporosis, sarcopenia and osteosarcopenia, and related complications, loss of accurate information on the distribution of related risk factors leftovers a major concern for policymakers in some countries and expanding appropriate interventions should be prioritized. To do this, a precise depiction of the situation, determination of the related risk factors in detail, providing acceptable strategies for prevention and treatment are required. The number of people living with dependency is set to dramatically increase in the coming decades due to aging populations and lifestyle changes. Musculoskeletal disorders are amongst the most impactful ailments that result in the inability to live independently. The forthcoming growth in the number of people living with dependency will place significantly greater demands on our systems of care. Despite much research for slowing the decline and prevention of related complications, lack of accurate information on the risk factors pose a major roadblock for policymakers in some countries as implementation of appropriate interventions needs to be prioritized. For these reasons, precise diagnosis of these disabilities, their underlying risk factors and proven strategies for prevention and treatment need definition.
Author: Paolo Falaschi
Publisher: Springer Nature
ISBN: 3030481263
Category : Anesthesiology
Languages : en
Pages : 355
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Book Description
This new open access edition supported by the Fragility Fracture Network aims at giving the widest possible dissemination on fragility fracture (especially hip fracture) management and notably in countries where this expertise is sorely needed. It has been extensively revised and updated by the experts of this network to provide a unique and reliable content in one single volume. Throughout the book, attention is given to the difficult question of how to provide best practice in countries where the discipline of geriatric medicine is not well established and resources for secondary prevention are scarce. The revised and updated chapters on the epidemiology of hip fractures, osteoporosis, sarcopenia, surgery, anaesthesia, medical management of frailty, peri-operative complications, rehabilitation and nursing are supplemented by six new chapters. These include an overview of the multidisciplinary approach to fragility fractures and new contributions on pre-hospital care, treatment in the emergency room, falls prevention, nutrition and systems for audit. The reader will have an exhaustive overview and will gain essential, practical knowledge on how best to manage fractures in elderly patients and how to develop clinical systems that do so reliably.
Author: J. Robin Harris
Publisher: Springer
ISBN: 9811336814
Category : Medical
Languages : en
Pages : 502
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Book Description
This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.
Author: Connie M. Weaver
Publisher: Springer
ISBN: 3319984640
Category : Medical
Languages : en
Pages : 264
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Book Description
This book comprehensively covers the topics and discussions covered at the 10th International Symposium on Nutritional Aspects of Osteoporosis. It is the only international meeting that exclusively covers the role of nutrition on musculoskeletal health and function. Current thinking on the role of nutrition on bone and muscle development and health, and as a means of preventing osteoporosis, falls and fractures is covered. The latest evidence on the potential roles that protein, potassium, B vitamins, vitamin D, omega-3 fatty acids, and flavonoids in the context of bone and muscle health are also discussed. Nutritional Influences on Bone Health reviews the role of nutrition in bone health and its potential role in preventing osteoporosis and sarcopenia in ageing populations, providing a valuable and practically applicable resource for practising and trainee health and medical professionals.
Author: Yasser El Miedany
Publisher: Springer Nature
ISBN: 303087950X
Category : Medical
Languages : en
Pages : 903
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Book Description
This book provides a review of the most recent data on osteoporosis and bone health, presenting a vision of diagnosis and management for the year 2021 and beyond. It covers all pertinent aspects of bone health including diagnosis, fracture prevention, optimized practice, impaired orthostasis, and falls. The book examines recent developments in therapeutics, including goal-directed therapy, individualizing therapy, sequential and combined therapies, pharmaceuticals, and anabolic vs. antiresorptive therapy. In addition, it provides an in-depth overview of osteoporosis and bone health in complex patients, covering Duchene dystrophy, renal failure, periodontal diseases, and steroid-induced osteoporosis as well as considerations for pediatric populations and men. New Horizons in Osteoporosis Management is an essential resource for physicians and related professionals, residents, fellows, graduate students and nurses in rheumatology, endocrinology, radiology, pediatrics, primary care, and internal medicine.
Author: Diana Kuh
Publisher: Oxford University Press, USA
ISBN: 0199656517
Category : Family & Relationships
Languages : en
Pages : 299
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Book Description
This title investigates the lifetime determinants of healthy ageing and their implications for policy and practice, bringing together authorities in ageing research and knowledge transfer from across the world.
Author: Jozef Rovenský
Publisher: Springer
ISBN: 3319311697
Category : Medical
Languages : en
Pages : 372
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Book Description
This book covers all aspects of the specialized field of gerontorheumatology, providing a complete overview of rheumatic and musculoskeletal diseases and related conditions in the elderly. The emphasis is particularly on pathogenesis, diagnosis, prevention, and treatment, including the latest advances in biological and pharmacological therapy and potential treatment side effects. The book will provide the reader with a keen awareness of the characteristic features, distinctive etiologies, and different courses of the various disorders of the musculoskeletal system in the geriatric population. Diagnostic and treatment considerations of special relevance in daily practice are highlighted, and the importance of comorbidities and their rheumatic consequences is also emphasized. The book will be of value for gerontologists, rheumatologists, internists, and rehabilitation physicians and will offer excellent guidance for general practitioners, who are typically the first to deal with disorders of the musculoskeletal system in elderly patients.
