Recent Advances in Pediatric Cancer Predisposition Syndromes PDF Download
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Author: Angela Mastronuzzi
Publisher: Frontiers Media SA
ISBN: 2889667146
Category : Medical
Languages : en
Pages : 123
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Book Description
We would like to acknowledge Dr. Giada Del Baldo and Dr. Mariachiara Lodi from IRCCS Bambino Gesù Children’s Hospital have acted as coordinator and have contributed to the preparation of the proposal for this Research Topic.
Author: Angela Mastronuzzi
Publisher: Frontiers Media SA
ISBN: 2889667146
Category : Medical
Languages : en
Pages : 123
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Book Description
We would like to acknowledge Dr. Giada Del Baldo and Dr. Mariachiara Lodi from IRCCS Bambino Gesù Children’s Hospital have acted as coordinator and have contributed to the preparation of the proposal for this Research Topic.
Author: Nathaniel H. Robin
Publisher: Elsevier Health Sciences
ISBN: 0323495966
Category : Medical
Languages : en
Pages : 350
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Book Description
Get a quick, expert overview of the many key facets of pediatric cancer genetics with this concise, practical resource by Dr. Nathaniel H. Robin and Meagan Farmer, MS, CGC, MBA. Ideal for pediatric oncologists and all providers who care for children, this easy-to-read reference addresses the remarkable potential of genetic testing as well as the complexities of choosing the correct test, understanding the results, and counseling the family. Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counselors. Highlights examples of syndromes that present in childhood and increase susceptibility to cancer. Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer. Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples. Consolidates today’s available information and guidance in this timely area into one convenient resource.
Author: Cristal Namuhoranye
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
"Background: Cancer predispositions syndromes (CPSs) are genetic conditions that increase the likelihood of developing cancer throughout a patient's lifetime. For pediatric cancer patients, CPSs are particularly relevant, as this population is less likely to develop malignancies from environmental exposures or other cancer-associated lifestyle factors. In fact, recent advances in the field of cancer genetics have elucidated the importance of recognizing the multitude of CPSs that may impact treatment plans, cancer surveillance and/or preventative measures for pediatric patients and their families. As a result, the last 20 years have seen a rise in decision-support tools (DSTs) that aim to guide health care practitioners in their evaluations of underlying CPSs. Currently, the scope of DSTs used to evaluate pediatric CPSs has yet to be described and their clinical application across Canadian institutions is not well understood. Objectives: The primary goal of this thesis is to identify, describe and categorize the features of DSTs developed for the pediatric oncology population. The second goal is to establish how these tools are being adopted in clinical settings, by assessing their utility to pediatric hematologist- oncologists (PHOs) across Canadian tertiary-care hospitals. Methods: An initial scoping review was performed to identify the pediatric-adapted DSTs that utilize the patient's clinical features to determine whether they are likely to have an underlying CPS. Using the Joanna Briggs Institute scoping review methodology, a systematic search strategy was developed and customized for MEDLINE and EMBASE databases. Subsequently, the tools identified in the scoping review informed a survey electronically distributed to PHOs across the 16 largest pediatric oncology departments in Canada. Their awareness and attitude towards DSTs were solicited on an anonymous basis. Results: Fourteen DSTs were identified, of which (8/14) (57%) have been internally or externally validated for clinical use. Half of the DSTs were specific to one CPS (7/14); the majority were published in a paper-based format (11/14); developed to input the patient's tumour type (14/14), family history of cancer (12/14), non-malignant physical findings (8/14); and developed to output their recommendation in a dichotomous form (10/14).With the online survey, a total of 36 responses from PHOs were recorded: 18/36 (50%) of the respondents had previously used a DST, while 15/36 (41.7%) had not, and 3 were uncertain. Users of DSTs did not solely rely on the tool's recommendation but used it as part of their decision-making process. Non-DST users were often unaware of the existence of these tools or how to gain access to them. Both DST users and non-users stated that a tool's ease-of-use, its accessibility, and its promotion by their academic institution constitute the most important features for a tool's adoption into their clinical practice.Conclusion: Fourteen pediatric CPS DSTs were identified through a scoping review; these were developed with a wide range of input/output parameters, formats, and types of CPSs and malignancies being evaluated. Despite the need for additional resources, the use of DSTs in clinical settings is not prominent, as half of the surveyed physicians have not previously used a DST and most tools remain unknown to them. With further development of DSTs' ease-of-use, accessibility, and evidence of their clinical benefit, adoption of DSTs in clinical practices across the country may become more systematic and lead to the increased recognition of CPSs in pediatric patients"--
Author: Hans D. Ochs
Publisher:
ISBN: 019514774X
Category : Medical
Languages : en
Pages : 745
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Book Description
The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Author: Presidential Commission for the Study of Bioethical Issues
Publisher: CreateSpace
ISBN: 9781508807643
Category : Medical
Languages : en
Pages : 156
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Book Description
Anticipate and Communicate is the Bioethics Commission's sixth major report. In this report the Bioethics Commission offers specific recommendations for the management of incidental and secondary findings in clinical, research and direct-to-consumer settings. Emerging medical technologies, changing cost structures, and evolving medical practice make the likelihood of discovering incidental and secondary findings across contexts a growing certainty. Such findings can be lifesaving, but also can lead to uncertainty and distress if they are unexpected or identify conditions for which no effective treatment is available.
Author: David Malkin
Publisher: Springer Nature
ISBN: 3030744485
Category : Medical
Languages : en
Pages : 495
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Book Description
This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the ‘disease-related’ chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where ‘modern’ technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.
Author: Philip A. Pizzo
Publisher: Lippincott Williams & Wilkins
ISBN: 1496318765
Category : Medical
Languages : en
Pages : 3581
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Book Description
Now thoroughly updated to include new advances in the field,and with regular content updates to the eBook, Principles and Practice of Pediatric Oncology, 7th Edition remains the gold standard text for the care and research of children with cancer. This authoritative reference is the single most comprehensive resource on the biology and genetics of childhood cancer and the diagnosis, multimodal treatment, and long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this 7th Edition provides expert guidance on state-of-the-art, multidisciplinary care for children and families. Stay up to date with the most recent advances in the field with the contributions by new and returning contributors, including the perspective from patients and parents in the chapter titled “The Other Side of the Bed.” Reference your eBook version for key updates in the field during the life of the edition! Chapters included on palliative care and education. Supportive care is covered broadly and specifically – in contexts such as emergencies, infectious disease, and nutrition. The most updated and authoritative information is provided by the leading experts in the field. Gain a thorough understanding of every aspect of pediatric oncology, with comprehensive information regarding basic science, diagnostic tools, principles of treatment, and clinical trials, as well as highly detailed, definitive coverage of each pediatric malignancy. Collaborate more effectively with others on the cancer care team to enhance quality-of-life issues for patients and families. Understand the cooperative nature of pediatric oncology as a model for cancer research with information from cooperative clinical trial groups and consortia.
Author: National Academies of Sciences Engineering and Medicine
Publisher:
ISBN: 9780309683494
Category :
Languages : en
Pages :
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Book Description
Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.
Author: Rosalind A. Eeles
Publisher: John Wiley & Sons
ISBN: 1118991060
Category : Medical
Languages : en
Pages : 456
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Book Description
Cancer Prevention and Screening offers physicians and all clinical healthcare professionals a comprehensive, useful source of the latest information on cancer screening and prevention with both a global and a multidisciplinary perspective. Includes background information on epidemiology, cancer prevention, and cancer screening, for quick reference Offers the latest information for clinical application of the most recent techniques in prevention and screening of all major and many lesser cancer types Emphasises the importance of multidisciplinary teamwork in cancer screening Highlights frequent dilemmas and difficulties encountered during cancer screening Provides clear-cut clinical strategies for optimal patient education, communication, and compliance with cancer prevention techniques
Author: Stephan D. Voss
Publisher: Springer
ISBN: 3030037770
Category : Medical
Languages : en
Pages : 408
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Book Description
This book, co-authored by an internationally acclaimed team of experts in the field of pediatric oncologic imaging, provides a comprehensive update on new advances in diagnostic imaging as they relate to pediatric oncology. In contrast to other oncologic imaging texts focusing on the radiology of specific tumors, this book emphasizes the important fundamentals of imaging that every child with a new or treated malignancy receives. Guidance is provided on the selection and use of appropriate imaging techniques, with individual chapters devoted to each of the major cross-sectional imaging modalities used in the detection and follow-up of pediatric cancers, including PET-CT, PET-MRI, whole-body MRI, and diffusion-weighted MRI. Additional nuclear medicine techniques are addressed, and detailed attention is paid to more advanced areas of practice such as contrast-enhanced ultrasound, pediatric interventional radiology techniques, radiation treatment planning, and radiation dose considerations (ALARA). Other areas covered include screening of children with cancer predisposition syndromes, treatment related complications, potential pitfalls during neuro-oncologic imaging, and the risks and benefits inherent in post-therapy surveillance imaging.
