Author: Susanna Valanne
Publisher: Frontiers Media SA
ISBN: 2889661911
Category : Science
Languages : en
Pages : 221
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: Susanna Valanne
Publisher: Frontiers Media SA
ISBN: 2832550835
Category : Medical
Languages : en
Pages : 116
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Book Description
The fruit fly Drosophila melanogaster is an established tool to study mechanisms of innate immunity. Drosophila flies and larvae launch elegant humoral and cellular innate immune responses against bacteria, viruses, fungi and parasites. The humoral immune response is based on microbial recognition primarily by peptidoglycan recognition proteins leading to the production of antimicrobial peptides (AMPs). In the past few decades, Drosophilists have dissected how flies react to systemic bacterial and fungal infections at the molecular level and shown how these mechanisms are conserved from human to man. Fly humoral immune response is mainly mediated by two evolutionarily conserved NF-κB signaling pathways, the Toll and the Immune deficiency (Imd) pathways. The discovery of the Toll receptor as a key regulator of immune response, first in cultured Drosophila cells and then in Drosophila in vivo, formed the basis of the Toll-Like Receptor (TLR) research in humans and mammals. More recently, this field has broadened considerably, including e.g. the antimicrobial responses taking place in the gut. Another interesting aspect related to innate immunity is the antiviral immune mechanisms found in Drosophila. Best understood are the mechanisms based on RNAi, primarily against RNA virus infections. More recently, the evolutionarily conserved molecule STING has been shown to integrate responses against both viruses and bacteria.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: L. Du Pasquier
Publisher: Springer Science & Business Media
ISBN: 3642596746
Category : Medical
Languages : en
Pages : 324
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Book Description
The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo lecular contexts in which the mechanism was introduced.
Author: Nancy E. Beckage
Publisher: Academic Press
ISBN: 008091649X
Category : Science
Languages : en
Pages : 383
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Book Description
Both volumes of Parasites and Pathogens of Insects provide in-depth coverage of the interface between insect parasites and pathogens and hosts, and explore the relationships between these partners. They emphasize biochemical and molecular interactions, basic biology, and the roles of hormones, receptors, and other cellular components in modulating interactions between host insects and attacking agents. These topics also are assessed in relation to biotechnology and biological control.In the short term, these volumes fill a void in current literature by emphasizing basic interactions at the biochemical and molecular levels. In the long term, these interactions may provide avenues for exploitation to enhance the rate of "beneficial" parasitism or to reduce the rates of disease transmission and infection of vertebrate hosts. - Presents the latest information on insect parasites and pathogens - Describes biochemical and molecular host-parasite and host-pathogen relationships - Covers mechanisms of insect pathogenicity and resistance - Provides exceptional breadth of coverage and authoritative reviews - Special topics - Transposable elements in insect pathogens - Co-evolution and gene transfer between hosts and invaders - Biological control
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309180686
Category : Medical
Languages : en
Pages : 102
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Book Description
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
Author: Laura Vesala
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: Virgil Schijns
Publisher: Elsevier
ISBN: 0080457215
Category : Medical
Languages : en
Pages : 396
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Book Description
Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. - Contributions from leading international authorities in the field - Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system - Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator
Author: Petros Ligoxygakis
Publisher: Academic Press
ISBN: 9780128117750
Category : Science
Languages : en
Pages : 0
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Book Description
Insect Immunity, Volume 52 provides readers with the latest interdisciplinary reviews on the topic. It is an essential reference source for invertebrate physiologists, neurobiologists, entomologists, zoologists and insect chemists, providing invaluable chapters on Insect Antimicrobial Defenses: A Brief History, Recent Findings, Biases, and a Way Forward in Evolutionary Studies, Phagocytosis in Insect Immunity, The Melanization Response in Insect Immunity, Microbiota, Gut Physiology, and Insect Immunity, Intestinal Stem Cells: A Decade of Intensive Research in Drosophila and the Road Ahead, and Insect Symbiosis and Immunity: The Bean Bug-Burkholderia Interaction as a Case Study, along with other related topics.
Author: Mariusz Skwarczynski
Publisher: William Andrew
ISBN: 0323400299
Category : Medical
Languages : en
Pages : 462
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Book Description
This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. - Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development - Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development - Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines
