Reaction Chemistry of Chiral Titanium Complexes PDF Download
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Author: Elizabeth Joy Duvall
Publisher:
ISBN:
Category : Enantioselective catalysis
Languages : en
Pages : 54
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Book Description
Author: Elizabeth Joy Duvall
Publisher:
ISBN:
Category : Enantioselective catalysis
Languages : en
Pages : 54
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Book Description
Author: Helene Pellissier
Publisher: World Scientific
ISBN: 1783268964
Category : Science
Languages : en
Pages : 278
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Book Description
Chiral titanium complexes are low-cost, low-toxicity and high-efficiency catalysts. Impressive progress on enantioselective titanium-catalysed transformations has been achieved in the past seven years, with exciting new discoveries ranging from basic reactions to novel methodologies. Despite this, the field has not been substantially reviewed since 2008.This book contains up to date research and covers all types of enantioselective transformations using chiral titanium catalysts. It illustrates the economic, health, and environmental benefits of chiral titanium catalysts, showing the types of highly enantioselective reactions that they are able to induce are unlimited.Work presented here is aimed at researchers in organic and catalytic chemistry, and has been carefully curated to encourage future research possibilities.
Author: Manfred T. Reetz
Publisher: Springer Science & Business Media
ISBN: 3642707041
Category : Science
Languages : en
Pages : 244
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Book Description
Titanium has been used to perform many kinds of reactions in organic and inorganic chemistry. The present book is concerned primarily with a new development in titanium chemistry which is useful in organic synthesis. In 1979/80 it was discovered that the titanation of classical carbanions using C1TiX leads to species with reduced basicity and reactivity. This increases 3 chemo-, regio-and stereo selectivity in reactions with organic compounds such as aldehydes, ketones and alkyl halides. Many new examples have been reported in recent times. Since the nature of the ligand X at titanium can be widely varied, the electronic and steric nature of the reagents is easily controlled. This helps in predicting the stereochemical outcome of many of the C-C bond forming reactions, but the trial and error method is still necessary in other cases. One of the ultimate objectives of chemistry is to understand correlations between structure and reactivity. Although this goal has not been reached in the area of organotitanium chemistry, appreciable progress has been made. A great deal of physical and computational data of organotitanium compounds described in the current and older literature (e. g. , Ziegler-Natta type catalysts) has been reported by polymer, inorganic and theoretical chemists. It is summarized in Chapter 2 of this book, because some aspects are useful in understanding reactivity and selectivity of organo titanium compounds in organic synthesis as described in the chapters which follow.
Author: Sami Klaib
Publisher:
ISBN:
Category :
Languages : en
Pages : 116
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Book Description
Author: Carmen Hernández Cervantes
Publisher: Universidad Almería
ISBN: 8416642109
Category : Science
Languages : en
Pages : 329
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Book Description
This thesis deals with the Ti(III) catalyzed synthesis of exocyclic allenes and the development of new titanocene complexes. It is structured in six chapters: Chapter 1 is a general introduction about the generation and reactivity of [TiCp2Cl]. A review about the different [TiCp2Cl] catalyzed or promoted reactions reported to date, is included. Chapter 2 is divided in introduction and results and discussion. In the introduction, an overview about the promoted or catalyzed methodologies, already available for the synthesis of α-allenols, is included. Results and discussion section is sub-divided in other two parts. The first one describes the synthesis of carbocyclic or nitrogen heterocyclic precursors bearing a propargyl halide and a carbonyl group. Next, the [TiCp2Cl] catalyzed synthesis of exocyclic allenols is studied. Additionally, a mechanistic study through deuterium incorporation and reaction of secondary propargyl halide precursors is performed. In the second part, the preparation of oxygen precursors and its cyclization are studied. In chapter 3, there is an introduction about enantioselective syntheses using chiral titanocene catalysts. The results and discussion section deals with the enantioselective cyclization of some of the precursors previously prepared using precatalyst (R,R)-ethylenebis(4,5,6,7-tetrahydro-1-indenyl) titanium(IV), also known as Brintzinger complex. A formal synthesis of the alkaloid (})-stemoamide is carried out in chapter 4, being the key step for this synthesis the generation of an α-allenol derivative through a [TiCp2Cl] catalyzedcyclization. This chapter is also divided in an introduction, in which a review about the different methods of synthesis of stemoamide are included, and results and discussion. Chapter 5 compiles the project that I have developed during my research stay at University of Bonn, under the supervision of Prof. Gansauer. The target of this project was to develop an azide functionalized short linker titanocene derivative with the aim of linking it to a surface by click chemistry. The chapter is divided in introduction and results and discussion. In the introduction the different methodologies for the synthesis of titanocene derivatives are reviewed. This section also includes the background in which this project is based. Chapter 6 includes the experimental part. In this chapter all reactions performed during the development of this thesis, as well as the spectroscopic characterization of compounds, are compiled.
Author: Jacek Mlynarski
Publisher: John Wiley & Sons
ISBN: 3527802150
Category : Technology & Engineering
Languages : en
Pages : 520
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Book Description
A complete overview covering the application of metal-based chiral Lewis acids from all parts of the periodic table, the Author emphasizes the most recent contributions to the field as well as prominent direction of development. The book discusses the design of chiral complexes as well as a wide spectrum of reactions promoted by various chiral Lewis acids, including water-compatible acids as well as the most important applications in the chemical and pharmaceutical industries. A must-have for catalytic and organic chemists working in the field, both in academia and industry, as well as pharmaceutical and medicinal chemists.
Author:
Publisher: Newnes
ISBN: 0080951686
Category : Science
Languages : en
Pages : 5635
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Book Description
Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.
Author: Jen Tiong Pei
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 0
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Book Description
This Thesis describes the synthesis and characterisation of titanium hydrazido(2- ) and alkylidene hydrazido(2- ) complexes and their reactivity towards unsaturated molecules. Exploration of the bonding in titanium hydrazido(2- ) and alkylidene hydrazido(2- ) complexes is performed through structural and computational studies. Chapter 1 introduces current Group 4 hydrazido chemistry in comparison to Group 4 imido and mid/late metal hydrazido examples. Current Group 4 alkylidene hydrazido chemistry is also described. Chapter 2 describes the synthesis, bonding and the novel reaction chemistry of titanium hydrazido(2- ) half-sandwich complexes. Novel reactivity at the Ti=N, bond is presented with the mechanisms of some of these transformations probed by Density Functional Theory (DFT) calculations. Chapter 3 describes the novel reaction chemistry of Cp*Ti{MeC(Nipr)2} (NNMe2) in comparison to its imido and diphenyl hydrazido analogues. Novel reactivity at both Ti=N, and Na-N~ bonds is presented with the mechanisms of some of these transformations probed by Density Functional Theory (DFT) calculations. Chapter 4 describes the synthesis and characterisation of a new titanium alkylidene hydrazido(2- ) complex. The bonding of the alkylidene hydrazido(2- ) ligand is explored through structural and computational studies. Novel reactivity at Ti=N, and Na-N~ bonds is presented. Chapter 5 presents full experimental procedures and characterising data for the new complexes reported. CD Appendix contains .cif files for all new crystallographically characterised complexes described.
Author: H. S. Rashid
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Michael B. Smith
Publisher: John Wiley & Sons
ISBN: 0470084944
Category : Science
Languages : en
Pages : 2379
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Book Description
The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. New features include: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations
