Quantifying and Controlling the Nano-Architecture of Neuronal Synapses PDF Download
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Author: Xiaobing Chen
Publisher: Frontiers Media SA
ISBN: 2832500846
Category : Science
Languages : en
Pages : 195
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Book Description
Author: Xiaobing Chen
Publisher: Frontiers Media SA
ISBN: 2832500846
Category : Science
Languages : en
Pages : 195
Get Book Here
Book Description
Author: Jacopo Lamanna
Publisher: Frontiers Media SA
ISBN: 2832536379
Category : Science
Languages : en
Pages : 117
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Book Description
Synapses represent a unique neuronal compartment specialized in communication. The morpho-functional investigation of the synapse has always been hindered by its tiny size and high density of molecular elements, but specific technological and methodological advances helped us to reduce these limitations. As the matter of fact, in recent years, we have witnessed the continuous development of new methods allowing measuring and controlling synaptic activation both in vitro and in vivo. These include new genetically encoded sensors of synaptic exo-endocytosis, but also engineered synaptic proteins able to inhibit the release of neurotransmitters. Furthermore, new promising tools allow changing the functional properties of synapses in a plasticity-like manner. All these methodological advances are likely to generate unprecedented knowledge about the dynamics of synaptic transmission and plasticity at several levels of the nervous system. Nevertheless, in most cases, the implementation of these new methods remains technically demanding, likely due to the high complexity of their operating principle. Hence, it would be worth refining and potentiating these tools in order to extend the range of experimental settings for their application.
Author: Anup Das
Publisher: Frontiers Media SA
ISBN: 2832553184
Category : Science
Languages : en
Pages : 235
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Book Description
Spiking Neural Networks (SNN) closely imitate biological networks. Information processing occurs in both spatial and temporal manner, making SNN extremely interesting for the pertinent mimicking of the biological brain. Biological brains code and transmit the sensory information in the form of spikes that capture the spatial and temporal information of the environment with amazing precision. This information is processed in an asynchronous way by the neural layer performing recognition of complex spatio-temporal patterns with sub-milliseconds delay and at with a power budget in the order of 20W. The efficient spike coding mechanism and the asynchronous and sparse processing and communication of spikes seems to be key in the energy efficiency and high-speed computation capabilities of biological brains. SNN low-power and event-based computation make them more attractive when compared to other artificial neural networks (ANN).
Author: George J. Augustine
Publisher: Frontiers Media SA
ISBN: 2889451755
Category :
Languages : en
Pages : 127
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Book Description
Development of new imaging technologies in recent years has transformed neuroscience in profound ways. Following on the heels of the revolution based on the Green Fluorescent Protein, refined genetically-encoded fluorescent reporters and genetic targeting strategies now enable optical recording of synaptic transmission in defined neuronal populations at speeds approaching the enviable temporal resolution of electrophysiology. Super-resolution light microscopy permits observation of synapses and their molecular machinery at sub-diffraction resolution. At the ultrastructural level, automated forms of electron microscopy, improvements in specimen fixation methods, and recent efforts to correlate data from light and electron micrographs now make the reconstruction of functional neural circuits a reality. Finally, the use of optogenetic actuators, such as channelrhodopsins, allows precise temporal and spatial manipulation of neuronal activity and is revealing profound insights into the organization of neural circuits and their roles in behavior. This research topic highlights recent advances in both light and electron microscopy, with a specific focus on approaches that combine innovations from several different fields to obtain novel information about synapse structure and function. We are confident that this collection of articles - three original research papers, six reviews, one methods paper and one perspective article - will enable neuroscientists to achieve the next generation of experiments aimed at cracking the neural code.
Author: Charles Watson
Publisher: Academic Press
ISBN: 9780128141465
Category : Medical
Languages : en
Pages : 0
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Book Description
The Mammalian Spinal Cord provides a comprehensive account of the anatomy and histology of the spinal cord. The text covers the cytoarchitecture, chemoarchitecture, motor neuron distribution, long tracts, autonomic outflow, and gene expression in the spinal cord. A feature of the book is the inclusion of segment-by-segment atlases of the spinal cords of rat, mouse, newborn mouse, marmoset, rhesus monkey, and human. This book is an essential reference for researchers studying the spinal cord.
Author:
Publisher: Academic Press
ISBN: 0128121572
Category : Medical
Languages : en
Pages : 562
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Book Description
Cannabinoids and Their Receptors, Volume 593, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This updated volume includes comprehensive chapters on a variety of topics, including Real time cAMP signaling in response to CB1 activation, CB1 signaling in mitochondria, Lipidomics of cannabinoid systems, Studying endocannabinoid transport, Metabolic profiling of CB1 neutral antagonists, Approaches to assess biased signaling at the CB1 receptor, and the Development of CB1 allosteric modulators. - Continues the legacy of this premier serial with a new and updated release - Covers research cannabinoids and their receptors
Author: Jean-Claude Béïque
Publisher: Frontiers Media SA
ISBN: 2889764818
Category : Science
Languages : en
Pages : 250
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Book Description
Author: Paul R. Prucnal
Publisher: CRC Press
ISBN: 1498725244
Category : Science
Languages : en
Pages : 445
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Book Description
This book sets out to build bridges between the domains of photonic device physics and neural networks, providing a comprehensive overview of the emerging field of "neuromorphic photonics." It includes a thorough discussion of evolution of neuromorphic photonics from the advent of fiber-optic neurons to today’s state-of-the-art integrated laser neurons, which are a current focus of international research. Neuromorphic Photonics explores candidate interconnection architectures and devices for integrated neuromorphic networks, along with key functionality such as learning. It is written at a level accessible to graduate students, while also intending to serve as a comprehensive reference for experts in the field.
Author: Philippe Isope
Publisher: Frontiers Media SA
ISBN: 2889660001
Category : Medical
Languages : en
Pages : 223
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author:
Publisher:
ISBN:
Category : Biotechnology
Languages : en
Pages : 982
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Book Description
