Pseudomonas Aeruginosa, Biology, Genetics, and Host-pathogen Interactions

Pseudomonas Aeruginosa, Biology, Genetics, and Host-pathogen Interactions PDF Author: Dara W. Frank
Publisher: Frontiers E-books
ISBN: 2889190161
Category :
Languages : en
Pages : 164

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Book Description
The opportunistic pathogen Pseudomonas aeruginosa offers a rich variety of biologically relevant topics to explore and serves as a model system to understand the interactions of Gram-negative bacteria with human hosts. The organism adapts readily to most environments. It has a large and variable genome with a great deal of metabolic potential. P. aeruginosa encodes a variety of regulatory systems to fine tune gene expression and integrate environmental signals. This organism can infect both plants and animals and produces a plethora of enzymes and factors that can overcome host defenses. Moreover, it has the ability to change between the states of a sedentary colonizer to an invasive and highly motile organism. Clinically, the bacterium is resistant to many antibiotics making it difficult to treat and impossible to eradicate from the lungs of patients with cystic fibrosis. Intrinsic antibiotic resistance combined with an armamentarium of tissue degradative enzymes makes it imperative to possess a comprehensive understanding of the biology, genetics and pathogenesis of this organism so that novel therapeutics based on virulence product neutralization can be designed and implemented. This Research Topics issue will be devoted to updating the current understanding of P. aeruginosa systems as they relate to its different lifestyles in different environments. The underlying theme is to provide broad overviews and to integrate protein structure-function and gene regulation as it relates to the biology of this bacterium.

Pseudomonas Aeruginosa, Biology, Genetics, and Host-pathogen Interactions

Pseudomonas Aeruginosa, Biology, Genetics, and Host-pathogen Interactions PDF Author: Dara W. Frank
Publisher: Frontiers E-books
ISBN: 2889190161
Category :
Languages : en
Pages : 164

Get Book Here

Book Description
The opportunistic pathogen Pseudomonas aeruginosa offers a rich variety of biologically relevant topics to explore and serves as a model system to understand the interactions of Gram-negative bacteria with human hosts. The organism adapts readily to most environments. It has a large and variable genome with a great deal of metabolic potential. P. aeruginosa encodes a variety of regulatory systems to fine tune gene expression and integrate environmental signals. This organism can infect both plants and animals and produces a plethora of enzymes and factors that can overcome host defenses. Moreover, it has the ability to change between the states of a sedentary colonizer to an invasive and highly motile organism. Clinically, the bacterium is resistant to many antibiotics making it difficult to treat and impossible to eradicate from the lungs of patients with cystic fibrosis. Intrinsic antibiotic resistance combined with an armamentarium of tissue degradative enzymes makes it imperative to possess a comprehensive understanding of the biology, genetics and pathogenesis of this organism so that novel therapeutics based on virulence product neutralization can be designed and implemented. This Research Topics issue will be devoted to updating the current understanding of P. aeruginosa systems as they relate to its different lifestyles in different environments. The underlying theme is to provide broad overviews and to integrate protein structure-function and gene regulation as it relates to the biology of this bacterium.

Colloquium on Virulence and Defense in Host-Pathogen Interactions

Colloquium on Virulence and Defense in Host-Pathogen Interactions PDF Author: Noel T. Keen
Publisher: National Academies Press
ISBN: 0309070805
Category : Medical
Languages : en
Pages : 373

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Book Description


Pseudomonas aeruginosa as an Opportunistic Pathogen

Pseudomonas aeruginosa as an Opportunistic Pathogen PDF Author: Mario Campa
Publisher: Springer
ISBN: 9781461363248
Category : Medical
Languages : en
Pages : 0

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Book Description
Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It will provide a deeper understanding of the pathogen to physicians and surgeons caring for patients infected, or at risk of becoming infected, with Pseudomonas Aeruginosa.

Pseudomonas

Pseudomonas PDF Author: Pierre Cornelis
Publisher:
ISBN: 9781913652258
Category :
Languages : en
Pages : 244

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Book Description
The genome sequences of several pseudomonads have become available in recent years and researchers are beginning to use the data to make new discoveries about this bacterium. This concise volume reviews the most current and topical aspects of Pseudomonas molecular biology and genomics and is aimed at a readership of research scientists, graduate students and other specialists. Renowned international authors have contributed chapters on diverse topics including taxonomy, genome diversity, oligonucleotide usage, polysaccharides, pathogenesis, virulence, biofilms, antibiotic resistance and iron u.

Molecular Mechanisms of Bacterial Virulence

Molecular Mechanisms of Bacterial Virulence PDF Author: C.I. Kado
Publisher: Springer Science & Business Media
ISBN: 9401107467
Category : Science
Languages : en
Pages : 676

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Book Description
The growing body of information on bacteria pathogenic for humans, mammals and plants generated within the past ten years has shown the interesting conservation of newly identified genes that playa direct role in the pathogenic mechanism. In addition to these genes, there are also genes that confer host specificities and other traits important in pathogenesis on these pathogens. In this volume, we have organized the subject areas to best fit the concept on the way bacterial pathogens recognize, interact and invade the host, on the regulation of genes involved in virulence, on the genes involved in the elaboration of toxins and other pathogenic components such as iron sequestering proteins, and on the mechanisms of circumventing the host defense systems. These areas are divided into Sections. Section I covers the first step when the pathogen seeks its host, and Sections II through VI cover subsequent steps leading to pathogenesis while avoiding host defenses. We conclude this work with a chapter summarizing information on examples of virulence mechanisms that are highly conserved.

Metagenomics and Its Applications in Agriculture, Biomedicine and Environmental Studies

Metagenomics and Its Applications in Agriculture, Biomedicine and Environmental Studies PDF Author: Robert W. Li
Publisher: Nova Science Publishers
ISBN: 9781628086447
Category : Microbial ecology
Languages : en
Pages : 0

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Book Description
Metagenomics is the study of microbial communities sampled directly from their natural environment, without prior culturing. DNA sequencing (or alternatively, an assay of functional properties) is applied to the culture-independent analyses of complex and diverse ("meta") populations of microbes. The rapid growth of metagenomics entails an expanded focus on microbes in a wide range of basic and applied research fields, ranging from microbiology to agriculture, biomedicine to bioenergy, and from veterinary to clinical medicine. This book is an insightful and inclusive study on metagenomics and its applications.

Principles and Practice of Pediatric Infectious Diseases

Principles and Practice of Pediatric Infectious Diseases PDF Author: Sarah S. Long
Publisher: Saunders
ISBN: 9780702034688
Category : Medical
Languages : en
Pages : 1618

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Book Description
"In print, online, or on your mobile device, Principles and Practice of Pediatric Infectious Disease provides the comprehensive and actionable coverage you need to understand, diagnose, and manage the ever-changing, high-risk clinical problems caused by infectious diseases in children and adolescents. With new chapters, expanded and updated coverage, and increased worldwide perspectives, this authoritative medical reference offers the latest need-to-know information in an easily-accessible, high-yield format for quick answers and fast, effective intervention!"--Publisher's website.

Data Integration in the Life Sciences

Data Integration in the Life Sciences PDF Author: Erhard Rahm
Publisher: Springer Science & Business Media
ISBN: 3540213007
Category : Computers
Languages : en
Pages : 230

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Book Description
This book constitutes the refereed proceedings of the First International Workshop on Data Integration in the Life Sciences, DILS 2004, held in Leipzig, Germany, in March 2004. The 13 revised full papers and 2 revised short papers presented were carefully reviewed and selected from many submissions. The papers are organized in topical sections on scientific and clinical workflows, ontologies and taxonomies, indexing and clustering, integration tools and systems, and integration techniques.

Invertebrate Immunity

Invertebrate Immunity PDF Author: Kenneth Söderhäll
Publisher: Springer Science & Business Media
ISBN: 1441980598
Category : Medical
Languages : en
Pages : 338

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Book Description
It can be seen that the insects are the still attracting most research and researchers. However, an increasing interest is emerging to study new invertebrate groups, especially those where the genome is known. Even though Drosophila has been and still is an excellent model for immune studies, it is now clear that there are great differences between immune responses in Drosophila and that of several other invertebrates, which indeed calls for more research on other invertebrates

Plant-microbe Interactions 2

Plant-microbe Interactions 2 PDF Author: Gary Stacey
Publisher: Springer Science & Business Media
ISBN: 1461560535
Category : Science
Languages : en
Pages : 238

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Book Description
Plant-Microbe Interactions, Volume 2 Volume 1 of this series has made its appearance and dealt forcefully with impor tant current topics in the field of plant-microbe interactions. We believe that the quality of those chapters was high and should serve as a focal point for the state of the art as well as an enduring reference. Volume 2 builds upon these accom plishments. Chapter 1 discusses the fascinating lipo-chitin signal molecules from Rhizo bium, aspects regarding their biosynthesis, and the basis for host specificity. These molecules are a cardinal example of how microorganisms influence plant development and stimulate speculation that they have identified a previously un known aspect of plant hormone activity. Chapter 2 continues the discussion of Rhizobium by considering the trafficking of carbon and nitrogen in nodules. Al though the ostensible advantage of nodules to plants is the fixation of atmos pheric nitrogen, the actual process involved in supplying reduced nitrogen to the plant host is complex.