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Author: Keith D. Lindor
Publisher: Springer Science & Business Media
ISBN: 9401148848
Category : Medical
Languages : en
Pages : 187
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Book Description
The condition of prolonged obstructive jaundice with patent bile ducts was first described in 1851 by Addison and Gull of Guy's Hospital, London. The term primary biliary cirrhosis (PBC) was defined in 1950 by Ahrens and colleagues of the Rockefeller Institute, New York. The condition was considered rare but this changed in 1965 with the discovery of a definitive diagnostic serum mitochondrial antibody test and the recognition that a raised serum alkaline phosphatase value, often discovered incidentally, could be a diagnostic pointer. If the diagnosis is made earlier, the end stages are rarely reached as death is replaced by liver transplantation. On November 6th 1997, in Chicago, an International Faculty discussed in depth the clinical features, pathogenesis and treatment of PBC, no longer considered a rare disease. The course of PBC is long, but some 18 years after the discovery of a positive mitochondrial antibody test in a symptom free patient with normal serum biochemistry, 83% will have developed abnormal tests and 76% will be symptomatic. Identification of those who will progress rapidly is difficult. The serum antimitochondrial profile may be useful but this is a very specialist technique. Mathematical prognostic models are useful in therapeutic trials and in the selection and timing of patients for liver transplantation but have limited value in individual patients. An increasing serum bilirubin level remains the most important indicator of rapid progression. Its value however can be negated by the use of ursodeoxycholic acid which has a bilirubin-lowering effect.
Author: Keith D. Lindor
Publisher: Springer Science & Business Media
ISBN: 9401148848
Category : Medical
Languages : en
Pages : 187
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Book Description
The condition of prolonged obstructive jaundice with patent bile ducts was first described in 1851 by Addison and Gull of Guy's Hospital, London. The term primary biliary cirrhosis (PBC) was defined in 1950 by Ahrens and colleagues of the Rockefeller Institute, New York. The condition was considered rare but this changed in 1965 with the discovery of a definitive diagnostic serum mitochondrial antibody test and the recognition that a raised serum alkaline phosphatase value, often discovered incidentally, could be a diagnostic pointer. If the diagnosis is made earlier, the end stages are rarely reached as death is replaced by liver transplantation. On November 6th 1997, in Chicago, an International Faculty discussed in depth the clinical features, pathogenesis and treatment of PBC, no longer considered a rare disease. The course of PBC is long, but some 18 years after the discovery of a positive mitochondrial antibody test in a symptom free patient with normal serum biochemistry, 83% will have developed abnormal tests and 76% will be symptomatic. Identification of those who will progress rapidly is difficult. The serum antimitochondrial profile may be useful but this is a very specialist technique. Mathematical prognostic models are useful in therapeutic trials and in the selection and timing of patients for liver transplantation but have limited value in individual patients. An increasing serum bilirubin level remains the most important indicator of rapid progression. Its value however can be negated by the use of ursodeoxycholic acid which has a bilirubin-lowering effect.
Author: James S. Dooley
Publisher: John Wiley & Sons
ISBN: 1119237548
Category : Medical
Languages : en
Pages : 832
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Book Description
A new, fully updated edition of the world’s most famous book on liver diseases—with updating of all areas and inclusion of new specific topics, by internationally renowned specialists This brand new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world’s leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th Edition takes a different approach. Concentrating on the clinical decisions to be taken and the relevant supporting data, it is written and edited to maintain Sheila Sherlock's unique approach, in particular the clarity and layout of the text, and the explanatory figures and tables. The book is thus concise, highly accessible, and generously illustrated with over 700 attractive color figures. There is a pithy approach to each disease based both on evidence and on the authors’ experience, the hallmark of this book. Based on these elements, the 12th edition was awarded first prize in the 2012 British Medical Association Book Awards in the Internal Medicine category. Sherlock's Diseases of the Liver and Biliary System begins by introducing the anatomy and function of the liver to readers, continuing then with in-depth coverage of liver biopsy techniques and interpretation, and fibrogenesis and its assessment. There are then chapters on all aspects of liver and biliary disease including acute liver failure, cirrhosis, portal hypertension, hepatic encephalopathy, ascites, hepatitis B and C, alcohol and the liver, non-alcoholic fatty liver disease, drug related liver reactions, cholestatic, autoimmune and genetic liver diseases, benign and malignant tumours and not least liver transplantation. There are also chapters on the liver in pregnancy, in the neonate, infancy and childhood, in systemic diseases and in infections. This new edition also features four new individual chapters focusing on coagulation, non-invasive assessment of fibrosis and cirrhosis; vascular diseases of the liver and portal vein thrombosis, and nutrition in liver disease. Digital downloads of the figures from this edition are offered on a companion website. Internationally recognized and loved, world-renowned hepatology book, first published in 1955 Takes a one-of-a-kind, clinical approach maintaining Sheila Sherlock’s clarity and legacy of presentation Full colour throughout with 700 illustrative figures Wide faculty of international contributors Sherlock's Diseases of the Liver and Biliary System, 13th Edition is an ideal primer in hepatology for students and trainees in hepatology and gastroenterology, and a valuable resource for all specialist gastroenterologists and hepatologists, paediatricians, pathologists, radiologists, general physicians and specialist nurses.
Author: James Neuberger
Publisher: John Wiley & Sons
ISBN: 1119532604
Category : Medical
Languages : de
Pages : 336
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Book Description
Ein praxisorientierter Leitfaden zu autoimmunen Lebererkrankungen, Pathogenese, Diagnose und Management. Autoimmune Liver Disease Management and Clinical Practice erläutert alles Wissenswerte zum aktuellen Forschungsstand autoimmuner Lebererkrankungen und legt dabei den Schwerpunkt auf Diagnose und Behandlung. Nach einer ausführlichen Darstellung der heutigen Erkenntnisse in der Immunologie in Verbindung mit der Autoimmunität der Leber werden die vier wichtigsten autoimmunen Lebererkrankungen bei Erwachsenen und Kindern erläutert, einschließlich Management, Rolle von Lebertransplantationen, erprobte Ansätze des Patientenmanagements und Empowerment-Ansätze. Die Autoren, Experten des Fachgebiets, untersuchen im Detail autoimmune Lebererkrankungen und geben Kliniker Handreichungen zur Patientenunterstützung. Die folgenden Themenkomplexe werden unter anderem ausführlich behandelt: - Die vier autoimmunen Lebererkrankungen, deren Diagnose und Behandlungsoptionen. - Einsatz (und Missbrauch) von Autoantikörpern bei Diagnose und Behandlung. - Rolle und Zeitpunkt von Lebertransplantationen und die Auswirkung auf wiederkehrende autoimmune Lebererkrankungen und De-novo-Autoimmunhepatitis. - Optimales Patientenmanagement und patientenbezogene Pflege. Dieses Referenzwerk zeigt umfassend, im Detail und mit alltäglichem Praxisbezug die jüngsten Entwicklungen beim Management von Lebererkrankungen und richtet sich an Ärzte, Pflegepersonal und Experten im Gesundheitswesen.
Author: George Y. Wu
Publisher: Springer Science & Business Media
ISBN: 146146191X
Category : Medical
Languages : en
Pages : 192
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Book Description
Atlas of Dermatological Manifestations of Gastrointestinal Disease provides a comprehensive compendium of digestive tract diseases with dermatological manifestations. The work is arranged by digestive symptoms, with sections based on the specific digestive disease etiology. Each section contains paired chapters of text, one on gastrointestinal manifestations and the other on dermatological manifestations. The atlas includes clinical presentations, pathophysiology, differential diagnosis, diagnostic tests/procedures, pathology, and references presented with substantial numbers of images. Concise and easy to use, Atlas of Dermatological Manifestations of Gastrointestinal Disease is an important resource for gastroenterologists, dermatologists, and internists alike in the treatment of digestive tract diseases.
Author: David Jones Obe
Publisher: Independently Published
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
This is the Second Edition of this highly acclaimed book for people with the liver disease primary biliary cholangitis (PBC), fully updated and expanded in 2023 to take account of the substantial progress in the field over the three years since the publication of the first edition. This is the definitive guide to help patients with PBC beat the condition. Treatments for PBC have advanced rapidly in recent years and we are in a better position than ever to completely control it. With the information in this book you can make sure you are getting the best possible treatment, and find out what you can do to help yourself. Written by one of the world's leading experts on PBC, this book explains all aspects of the condition, from why people get it, to how it is diagnosed in the clinic, how it is treated and how you can beat the symptoms. It can be read as a thorough explanation; a textbook for patients. Alternatively, with "two-minute versions" for each of the chapters, you get can all the key facts quickly. The book also has a dictionary of PBC which will help you understand the technical terms and medical jargon that you may encounter. The book is also ideal for the relatives and partners of PBC patients to help them better understand their loved one's medical problems. It will also be really useful for students, doctors, nurses and other professionals who are encountering PBC for the first time and want to find out more. New for the second edition A chapter summarising what has changed in PBC in the three years since the first edition was published Extensive details of all the new and emerging drugs being used in trials in PBC More information on what the best management in clinic looks like and how to get it Expanded section on why people get fatigue and the new approaches to treating it in practice A frequently asked questions section directly answering the questions I get asked most frequently in clinic A revised look at the future of PBC taking on board all the recent advances A "know your numbers" section to help you understand how well your disease is controlled and to give you confidence in your discussions with doctors and nurses What people said about the first edition " An excellent book.....thank you for writing this" S "If you have PBC this is a must have book" C "This book is a bible for PBC" SS " This book is an absolute godsend......this amazing book is a must have for all PBC patients and their families" JP "An essential purchase" C "Professor Jones is amazing, thank you so much for writing this invaluable book" LE "Every piece of information you need to know and more is contained within this bible" PL
Author: Elizabeth J. Carey
Publisher: Springer
ISBN: 1493910132
Category : Medical
Languages : en
Pages : 265
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Book Description
Since the publication of the first edition, there have been advances in both the diagnosis and the management of many of the cholestatic liver diseases. Cholestatic Liver Disease, Second Edition thoroughly updates the topics previously addressed, such as primary biliary cirrhosis, primary sclerosing cholangitis and cholestatic variants of drug hepatotoxicity and viral disease. New treatments, such as the development of the farnesoid X receptor agonists for the treatment of PBC, are highlighted. Current guidelines and areas of uncertainty are also covered. Additionally, new chapters have been added to reflect the changing landscape of cholestatic liver disease. Cholestatic Liver Disease, Second Edition is a concise yet comprehensive summary of the current status of the field and is of value to clinicians and researchers interested in patients with cholestatic liver disease provide that will help to guide patient management and stimulate investigative efforts.
Author: Lawrence Samuel Friedman
Publisher:
ISBN: 9780443066337
Category : Medical
Languages : en
Pages : 481
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Book Description
Here's instant access to the symptoms, signs, differential diagnosis, and treatment for the full range of liver disorders. Written by an international 'who's who' of hepatology-and now in full color-this new 2nd Edition provides readers with top-notch, authoritative guidance they can count on! Discusses the hottest topics in the field, such as non-alcoholic steatohepatitis (NASH) and the latest information on liver transplantation. Includes expanded coverage of chronic hepatitis C, most notably the use of combination therapy with peginterferon and ribavirin and improvements in the management of the side effects of antiviral therapy. Offers the most recent therapeutic options for the management of chronic hepatitis B and advances in the understanding of the molecular biology of this virus. Updates the approach to the diagnosis of many liver diseases due to newer tests based on molecular techniques and advances in imaging. Features over 340 full-color illustrations. Uses a redesigned templated, outline format that makes reference a snap. Presents a concise, in-depth clinical summary-in an outline format-of the current practice of hepatology for each major disease entity. Provides a liberal use of tables, algorithms, and figures, rendering complex concepts understandable. Includes key point boxes at the beginning of each chapter, providing at-a-glance access to vital information. Includes alert symbols that highlight information that's critical to patient safety.
Author: A.L. Gerbes
Publisher: Springer Science & Business Media
ISBN: 9780792387657
Category : Medical
Languages : en
Pages : 410
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Book Description
Symposium in Honour of Gustav Paumgartner
Author: Edward L. Krawitt
Publisher: Elsevier Science Health Science Division
ISBN: 9780444828033
Category : Medical
Languages : en
Pages : 656
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Book Description
The second edition, which appears seven years after the first, is a more comprehensive text and addresses the many recent advances in basic and clinical science applicable to autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune aspects of viral-, drug- and alcohol-induced liver disease and hepatocellular cancer. Pathogenesis, diagnosis and treatment are discussed in depth in light of current understanding of the molecular mechanisms of autoimmunity as it applies to liver disease.
Author: Frederick J. Suchy
Publisher: Cambridge University Press
ISBN: 1139464035
Category : Medical
Languages : en
Pages : 995
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Book Description
Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
