Predictive Modeling of Human Microbiota and their Role in Health and Disease

Predictive Modeling of Human Microbiota and their Role in Health and Disease PDF Author: Hyun-Seob Song
Publisher: Frontiers Media SA
ISBN: 2889740919
Category : Science
Languages : en
Pages : 145

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Book Description

Predictive Modeling of Human Microbiota and their Role in Health and Disease

Predictive Modeling of Human Microbiota and their Role in Health and Disease PDF Author: Hyun-Seob Song
Publisher: Frontiers Media SA
ISBN: 2889740919
Category : Science
Languages : en
Pages : 145

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Book Description


Modeling the Transmission and Prevention of Infectious Disease

Modeling the Transmission and Prevention of Infectious Disease PDF Author: Christon J. Hurst
Publisher: Springer
ISBN: 3319606166
Category : Science
Languages : en
Pages : 290

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Book Description
This volume focuses on blocking disease transmission and the ecological perspective of pathogens and pathogenic processes. The chapters on blocking transmission cover the environmental safety of space flight, biocides and biocide resistance, as well as infection control in healthcare facilities. The book also offers insights into the ecological aspects of infectious disease, introducing the reader to the role of indigenous gut microbiota in maintaining human health and current discussions on environmentally encountered bacterial and fungal pathogens including species that variously cause the necrotizing skin disease Buruli ulcer and coccidioidomycosis. Further, it explores the influenza A virus as an example for understanding zoonosis. It is a valuable resource for microbiologists and biomedical scientists alike.

Environmental Chemicals, the Human Microbiome, and Health Risk

Environmental Chemicals, the Human Microbiome, and Health Risk PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309468698
Category : Science
Languages : en
Pages : 123

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Book Description
A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

The Human Microbiome

The Human Microbiome PDF Author:
Publisher: Academic Press
ISBN: 9780128137147
Category : Science
Languages : en
Pages : 0

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Book Description
Methods in Microbiology, Volume 44 presents the latest volume in the most prestigious series devoted to techniques and methodology in the field, with updated chapters that cover Metabolomics and the vaginal microbial ecosystem and health, Esophageal microbiome, Bioinformatics methods, Evolution of biomolecules, genomes and communities, and Gut microbial metabolism or the acquisition of the gut microbiome. Established for over 30 years, this comprehensive series provides ready-to-use recipes, the latest emerging techniques, and novel approaches on tried, tested and established methods.

The Microbiome in Health and Disease

The Microbiome in Health and Disease PDF Author:
Publisher: Academic Press
ISBN: 0128200014
Category : Science
Languages : en
Pages : 524

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Book Description
The Microbiome in Health and Disease, Volume 171 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Microbiome in health and disease, CNS development and microbiome in infants, A gut feeling in ALS, Microbiome (Virome) and virus infection, Bugs and Drugs: microbiome in medicine metabolism, Immunity, T cells, and microbiome, Salmonella (Bacterial) infection and cancer: of mice and men, and many other highly researched topics. Provides a novel theme and multiple disciplinary topics of microbiome research in basic and translational studies Presents an updated collection on bacteria, virus, fungi and their interactions in microbiome Includes a timely discussion on the tools and methods used for modeling and analysis of microbiome data

The Lung Microbiome

The Lung Microbiome PDF Author: Michael J. Cox
Publisher: European Respiratory Society
ISBN: 1849841020
Category : Medical
Languages : en
Pages : 261

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Book Description
Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.

The Human Microbiome, Diet, and Health

The Human Microbiome, Diet, and Health PDF Author: Food Forum
Publisher: National Academies Press
ISBN: 030926586X
Category : Medical
Languages : en
Pages : 197

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Book Description
The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

The Chemistry of Microbiomes

The Chemistry of Microbiomes PDF Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309458390
Category : Science
Languages : en
Pages : 133

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Book Description
The 21st century has witnessed a complete revolution in the understanding and description of bacteria in eco- systems and microbial assemblages, and how they are regulated by complex interactions among microbes, hosts, and environments. The human organism is no longer considered a monolithic assembly of tissues, but is instead a true ecosystem composed of human cells, bacteria, fungi, algae, and viruses. As such, humans are not unlike other complex ecosystems containing microbial assemblages observed in the marine and earth environments. They all share a basic functional principle: Chemical communication is the universal language that allows such groups to properly function together. These chemical networks regulate interactions like metabolic exchange, antibiosis and symbiosis, and communication. The National Academies of Sciences, Engineering, and Medicine's Chemical Sciences Roundtable organized a series of four seminars in the autumn of 2016 to explore the current advances, opportunities, and challenges toward unveiling this "chemical dark matter" and its role in the regulation and function of different ecosystems. The first three focused on specific ecosystemsâ€"earth, marine, and humanâ€"and the last on all microbiome systems. This publication summarizes the presentations and discussions from the seminars.

Genomic Applications in Pathology

Genomic Applications in Pathology PDF Author: George Jabboure Netto
Publisher: Springer
ISBN: 3319968300
Category : Medical
Languages : en
Pages : 631

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Book Description
​The recent advances in genomics are continuing to reshape our approach to diagnostics, prognostics and therapeutics in oncologic and other disorders. A paradigm shift in pharmacogenomics and in the diagnosis of genetic inherited diseases and infectious diseases is unfolding as the result of implementation of next generation genomic technologies. With rapidly growing knowledge and applications driving this revolution, along with significant technologic and cost changes, genomic approaches are becoming the primary methods in many laboratories and for many diseases. As a result, a plethora of clinical genomic applications have been implemented in diagnostic pathology laboratories, and the applications and demands continue to evolve rapidly. This has created a tremendous need for a comprehensive resource on genomic applications in clinical and anatomic pathology. We believe that our current textbook provides such a resource to practicing molecular pathologists, hematopathologists and other subspecialized pathologists, general pathologists, pathology and other trainees, oncologists, geneticists and a growing spectrum of other clinicians. With periodic updates and a sufficiently rapid time from submission to publication, this textbook will be the resource of choice for many professionals and teaching programs. Its focus on genomics parallels the evolution of these technologies as primary methods in the clinical lab. The rapid evolution of genomics and its applications in medicine necessitates the (frequent) updating of this publication. This text will provide a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays will be discussed together with issues related to reporting and the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms will be detailed. Genomic applications in pharmacogenomics, inherited genetic diseases and infectious diseases will also be discussed. The latest iteration of practice recommendations or guidelines in genomic testing put forth by stakeholder professional organizations such as the College of American Pathology and the Association for Molecular Pathology, will be discussed as well as regulatory issues and laboratory accreditation related to genomic testing. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.

The Value of Genetic and Genomic Technologies

The Value of Genetic and Genomic Technologies PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309184991
Category : Medical
Languages : en
Pages : 109

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Book Description
Knowing one's genetic disposition to a variety of diseases, including common chronic diseases, can benefit both the individual and society at large. The IOM's Roundtable on Translating Genomic-Based Research for Health held a workshop on March 22, 2010, to bring together diverse perspectives on the value of genetic testing, and to discuss its use in clinical practice.