Polyether Antibiotics: Biology PDF Download
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Author: John W. Westley
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 492
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Book Description
Author: John W. Westley
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 492
Get Book Here
Book Description
Author: J. W. Westley
Publisher: CRC Press
ISBN: 9780367451929
Category :
Languages : en
Pages : 432
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Book Description
This collection of essays will stimulate the use of ionophores in different research areas. It includes information on potential breakthroughs in the halogenated derivatives of lasalocid and ethers of antibiotic A204A, polyethers and analytical techniques used to unravel their complex structures.
Author: J. W. Westley
Publisher: CRC Press
ISBN: 1000944522
Category : Medical
Languages : en
Pages : 433
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Book Description
This collection of essays will stimulate the use of ionophores in different research areas. It includes information on potential breakthroughs in the halogenated derivatives of lasalocid and ethers of antibiotic A204A, polyethers and analytical techniques used to unravel their complex structures.
Author: Natanya Civjan
Publisher: John Wiley & Sons
ISBN: 1118391829
Category : Science
Languages : en
Pages : 437
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Book Description
Based on the award winning Wiley Encyclopedia of Chemical Biology, this book provides a general overview of the unique features of the small molecules referred to as "natural products", explores how this traditionally organic chemistry-based field was transformed by insights from genetics and biochemistry, and highlights some promising future directions. The book begins by introducing natural products from different origins, moves on to presenting and discussing biosynthesis of various classes of natural products, and then looks at natural products as models and the possibilities of using them in medicine.
Author: Stephen W. Queener
Publisher: Elsevier
ISBN: 0323162932
Category : Science
Languages : en
Pages : 441
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Book Description
The Bacteria: Volume IX: Antibiotic-Producing Streptomyces explores how Streptomyces, including actinomycetes, produce a variety of antibiotics such as aminocyclitols, ansamycins, macrolides, and tetracyclines. Topics covered range from physiology and fermentation to genetic recombination and chromosome mapping in Streptomyces, biomodification of antibiotics by Streptomyces, and biosynthesis of tylosin and erythromycin. The genome structure and evolution of Streptomyces are also discussed. This volume is comprised of 10 chapters and begins with a discussion on the taxonomy of Streptomyces based on morphology, physiological characteristics, the composition of cell constituents such as cell walls, and the presence of characteristic lipids, sugars, and quinones. The discussion then turns to the intraspecific and interspecific recombination in Streptomyces; pathways of DNA repair and mutagenesis in Streptomyces fradiae; strategies for isolation of improved Streptomyces mutants for antibiotic production; and derivation of DNA cloning vectors from Streptomyces phages. The biology and use of Streptomyces plasmids as cloning vectors are also described. The final chapter is devoted to major structural classes of antibiotics produced by Streptomyces, including anthracyclines and other quinones, ß-lactams, macrolides, nucleosides, peptides, polyenes, polyether antibiotics, and tetracyclines. This book will be of value to microbiologists, bacteriologists, biochemists, and biologists.
Author: Goutam Brahmachari
Publisher: John Wiley & Sons
ISBN: 3527684417
Category : Science
Languages : en
Pages : 544
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Book Description
Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.
Author: John Buckingham
Publisher: Chapman & Hall/CRC
ISBN: 9780412170508
Category : Science
Languages : en
Pages : 1000
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Book Description
Author: Satoshi Omura
Publisher: Academic Press
ISBN: 9780125264518
Category : Medical
Languages : en
Pages : 668
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Book Description
Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.
Author: Barrie W. Bycroft
Publisher: CRC Press
ISBN: 1482282151
Category : Science
Languages : en
Pages : 2118
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Book Description
Bacterial and parasitic diseases are the second leading cause of death worldwide, according to a report by the London School of Economics. Due to the emergence of drug-resistant "superbugs," like methicillin-resistant Staphylococcus aureus (MRSA), traditional antibiotics such as penicillin and its derivatives are in danger of becoming obsolete. In an effort to combat this problem, pharmaceutical companies continue to research new and effective antibiotics. The Dictionary of Antibiotics and Related Substances, Second Edition is a definitive reference work dealing with this crucially important class of biochemicals. It consists of a comprehensive survey of the antibiotic field, providing a single-volume resource and a significant update to the first edition published in 1988. Each dictionary entry contains the chemical name and synonyms, CAS Number, chemical structure, biological activity, and a concise bibliography. Entries include naturally occurring antibiotics, such as the beta-lactams (penicillins, cephalosporins, and carbapenems) and aminoglycosides; semisynthetic antibiotics—the most common type available—modified chemically from original compounds found in nature; and synthetic antibiotics, including the sulfonamides, the quinolones, and the oxazolidinones. It is estimated that there are approximately 10,000 antibiotics known, and this revised edition of the successful compilation covers all of the different classes. The dictionary also includes fully searchable downloadable resources.
Author: Sasadhar Majhi
Publisher: Elsevier
ISBN: 0443152705
Category : Science
Languages : en
Pages : 484
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Book Description
Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented. Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development. - Focuses on the current resistance mechanisms of antibiotics, chemical derivatization of antibiotics, and clinical applications of semisynthetic derivatives. - Includes discussion of the semisynthesis of natural products using green tools, green solvents, and eco-friendly catalysts. - Illustrates the concept of toxicity, the merits of transition-metal-free reactions, and the semisynthesis of natural products by introducing the oxygen atom(s) under transition-metal-free conditions.
