Plasticity of Myosin Heavy Chain Isoforms in Human Skeletal Muscle. Effects of Training and Detraining. Ph. D.-Thesis PDF Download
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Author: Jesper Løvind Andersen
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Jesper Løvind Andersen
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Jesper Løvind Andersen
Publisher:
ISBN:
Category :
Languages : en
Pages : 45
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Author: Roberto Bottinelli
Publisher: Springer Science & Business Media
ISBN: 1402051778
Category : Medical
Languages : en
Pages : 372
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The ability of striated muscle tissue to adapt to changes in activity or in working conditions is extremely high. In some ways it is comparable to the ability of the brain to learn. The interest in muscle adaptation is increasing in relation to the idea that physical fitness helps in the prevention of disease, may counteract the loss of physical performance and generally improves wellbeing. Plasticity is the word used since the late 1970’s to indicate collectively all the processes and mechanisms which form the background of muscle adaptation. This book aims to provide a systematic updating of the available knowledge on molecular and cellular mechanisms, as well as on changes at whole muscle level. The book means to be a guide and a help for people who enter the field as PhD or medical students, but is also a tool for refreshing and updating knowledge for people already active in the field in basic sciences as well as in applied disciplines such as neurology, sports science and rehabilitation.
Author: Peter G. Schantz
Publisher:
ISBN:
Category : Adaptation (Physiology)
Languages : en
Pages : 68
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Author: Antonios Matsakas
Publisher: diplom.de
ISBN: 3832482938
Category : Medical
Languages : en
Pages : 124
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Inhaltsangabe:Abstract: Skeletal muscle is a complex and heterogeneous tissue capable of remarkable adaptation in response to various stimuli such as exercise training. Molecular biology approaches have made a large contribution to our current understanding of how mechanical loading can alter gene expression and muscle protein synthesis rates in skeletal muscle. The steady-state level of a given mRNA is a function of both its rate of synthesis and its rate of degradation, implying that the rate of change in response to a cellular stimulus is dependent on the dynamics of mRNA turnover. Changes in muscle mRNA steady-state levels can be taken as an index of changes in gene expression, constituting currently one of the best described and understood molecular events that underlie muscle plasticity. The discovery of new growth factors involved in the regulation of muscle development provides a better understanding of the molecular mechanisms involved in the adaptation of skeletal muscle to exercise training. Since it has been shown that changes in contractile function can be brought about by switching on one subset and repressing another subset of genes, it was hypothesized that the steady state level of multiple mRNAs (growth factors and metabolic genes) involved in regulatory functions in a muscle which is frequently recruited during exercise is different between endurance trained versus untrained rats. Recent scientific data indicate that myostatin constitutes a limiting factor in normal muscle development playing a crucial role in skeletal muscle hypertrophy. Nevertheless, there are only scarce data so far about the role of myostatin in the exercise-induced skeletal muscle adaptation. The transient changes in regulatory and structural gene expression provide the molecular basis of the adaptability of the skeletal muscle to exercise stimulus. To get an insight into the molecular mechanisms of skeletal muscle adaptation, the main objective of this study was to examine the effect of both the short- and long- term effect of exercise (five day of swimming vs. chronic wheel running) on IGF-I and MSTN (positive and negative skeletal muscle regulators respectively) mRNA contents in male Wistar rats. Potential increase of positive and/or decrease of negative regulators of muscle growth lead to enhanced muscle-progenitor proliferation providing a new perspective in the mechanism of muscle adaptability. It was hypothesized that exercise training could be [...]
Author: Ming-Yuan Zhou
Publisher:
ISBN:
Category :
Languages : en
Pages : 95
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Author: Kunihiro Sakuma
Publisher: Springer
ISBN: 9811032920
Category : Medical
Languages : en
Pages : 295
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This book discusses recent advances and various topics in plasticity of skeletal muscle from the perspectives of morphology, biological function, and clinical applications. Skeletal muscle is a highly plastic organ to adapt to environmental various demands, appears to endocrine various myokines, which flow into blood to protect the recognizing function of brain and inhibit the appearance of several cancer tumorigenesis. The book deals with current stem-cell based, pharmacological, and nutritional therapies for muscle wasting (sarcopenia, cachexia, and muscular dystrophy). It also explains the roles of biological mediators such as PGC-1, transient receptor potential cation channels (TRPC), and AMPK in modulating muscle function. The functional roles of ubiquitin-proteasome system, autophagy-dependent signaling in muscle homeostasis, ribosome biogenesis, and redox regulation of mechanotransduction to modulate skeletal muscle mass are also covered. It is an essential resource for physicians, researchers, post-docs as well as graduate students in the field of sports science including rehabilitation therapy, exercise physiology, exercise biochemistry, and molecular biology dealing with skeletal muscle.
Author: Paige Christine Geiger
Publisher:
ISBN:
Category :
Languages : en
Pages : 436
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![The Effects of the Smooth Muscle Myosin Heavy Chain Loop 1 Isoforms on Smooth Muscle Kinetics [microform] PDF](https://books.google.com/books/content/images/frontcover/uPwiNAEACAAJ?fife=w80-h100)
Author: Karagiannis, Peter
Publisher: Ann Arbor, Mich. : University Microfilms International
ISBN:
Category :
Languages : en
Pages : 198
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Author: H. Klitgaard
Publisher:
ISBN:
Category :
Languages : en
Pages : 7
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