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Author: Ali Akbar Velayati
Publisher: Elsevier
ISBN: 0443217130
Category : Science
Languages : en
Pages : 339
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Book Description
Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances discusses the types of pili produced by the tuberculosis-causing bacterium, Mycobacterium tuberculosis (MTBC. The book examines the structure of pili shown under electron and atomic force microscopy and by using whole genome sequencing, outlines the importance of pili in mycobacterium tuberculosis. It also explores the role of pili in bacteria-host interactions and in drug development and delivery. Pili in Mycobacterium Tuberculosis opens with an overview of the structure, synthesis, and function of pili in bacteria. This includes taxonomy and the role of pili in diseases. The book also examines the preparation of Mycobacterium tuberculosis for electronic and atomic microscopy and looks at the different life cycles and susceptibility patterns of MTBC. It does on to discuss the expression and function of pili using whole genome sequencing and PCR-based methods and delves into bacteria host interactions. Lastly, it explores the development of new drugs and its delivery by pili. • Covers the structure, synthesis, and function of pili produced by the tuberculosis-causing bacterium, MTB • Introduces seven types of pili in MTB • Explains the mechanism of bacteria–host attachment and importance of this phenomena in MTB pili and other bacteria • Emphasizes the use of advances techniques to study and investigate the TB-bacilli and its interaction with host cells
Author: Ali Akbar Velayati
Publisher: Elsevier
ISBN: 0443217130
Category : Science
Languages : en
Pages : 339
Get Book
Book Description
Pili in Mycobacterium Tuberculosis: Structure, Function, and Therapeutic Advances discusses the types of pili produced by the tuberculosis-causing bacterium, Mycobacterium tuberculosis (MTBC. The book examines the structure of pili shown under electron and atomic force microscopy and by using whole genome sequencing, outlines the importance of pili in mycobacterium tuberculosis. It also explores the role of pili in bacteria-host interactions and in drug development and delivery. Pili in Mycobacterium Tuberculosis opens with an overview of the structure, synthesis, and function of pili in bacteria. This includes taxonomy and the role of pili in diseases. The book also examines the preparation of Mycobacterium tuberculosis for electronic and atomic microscopy and looks at the different life cycles and susceptibility patterns of MTBC. It does on to discuss the expression and function of pili using whole genome sequencing and PCR-based methods and delves into bacteria host interactions. Lastly, it explores the development of new drugs and its delivery by pili. • Covers the structure, synthesis, and function of pili produced by the tuberculosis-causing bacterium, MTB • Introduces seven types of pili in MTB • Explains the mechanism of bacteria–host attachment and importance of this phenomena in MTB pili and other bacteria • Emphasizes the use of advances techniques to study and investigate the TB-bacilli and its interaction with host cells
Author: Jean Pieters
Publisher: Springer
ISBN: 9783642402333
Category : Medical
Languages : en
Pages : 245
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Book Description
Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.
Author: Edward E.K. Baidoo
Publisher: Humana
ISBN: 9781493987566
Category : Science
Languages : en
Pages : 0
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Book Description
This detailed volume includes protocols that represent the breadth of microbial metabolomics approaches to both large-scale and small-scale experiments with intention of highlighting techniques that can be used for applications ranging from environmental microbiology to human disease. Utilizing mass spectrometry as their primary measurement tool, the chapters explore microbial metabolomics, metabolism and microbial physiology, metabolite sample preparation, current analytical techniques used to profile primary and secondary metabolites and lipids, as well as establishing data analysis workflows for targeted metabolomics, untargeted metabolomics, analysis of metabolic fluxes, and genome-scale models. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Microbial Metabolomics: Methods and Protocols serves as an ideal reference for both novice and advanced users and can be adapted to similar analytical platforms or customized to suit the needs of the researcher.
Author: Venketeshwer Rao
Publisher: BoD – Books on Demand
ISBN: 9535124757
Category : Medical
Languages : en
Pages : 396
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Book Description
Probiotic microorganisms are recognised as being beneficial for human health. Prebiotics are substrates that are used preferentially by the probiotic bacteria for their growth. A great deal of interest has been generated in recent years in identifying probiotic bacteria and prebiotics, their characterization, mechanisms of action and their role in the prevention and management of human health disorders. Together they are referred to as synbiotic. This book is in response to the need for more current and global scope of probiotics and prebiotics. It contains chapters written by internationally recognized authors. The book has been planned to meet the needs of the researchers, health professionals, government regulatory agencies and industries. This book will serve as a standard reference book in this important and fast-growing area of probiotics and prebiotics in human nutrition and health.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author:
Publisher: Academic Press
ISBN: 9780080860565
Category : Science
Languages : en
Pages : 620
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Book Description
Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control
Author: Barry R. Bloom
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 664
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Book Description
The authors discuss fundamental questions about the biology, genetics, mechanisms of pathogenicity, mechanisms of resistance, and drug development strategies that are likely to provide important new knowledge about TB and new interventions to prevent and treat this disease.
Author: Ali Akbar Velayati
Publisher: Academic Press
ISBN: 0128038802
Category : Medical
Languages : en
Pages : 226
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Book Description
Atlas of Mycobacterium Tuberculosis reveals in-depth information about mycobacterium tuberculosis which has never before been reported. Using atomic force microscopy (AFM), the in-depth phenotypic interaction that occurs in different stages of the tuberculosis lifecycle is illustrated, including resting, exponential, and dormant states. Coverage also includes the macroscopic and microscopic anatomy of mycobacterium, including pigmentation, morphology of colonies, size and shape, and the phenotypic changes from susceptible to resistant, all shown with images from electronic and atomic force microscopes. This book will open a new window into the results of molecular changes at the cellular level, guiding researchers and scientists to think in new ways about the area of cell wall and the reproductive and drug resistance phenomena surrounding tuberculosis. Identifies the different stages and morphological aspects of mycobacterium tuberculosis with the use of new microscopy techniques Includes never-before-seen photographs from the personal collection and scientific achievement of the authors Outlines the nature of the lifecycle of mycobacterium tuberculosis in relation to adaptation in humans
Author: Douglas I. Johnson
Publisher: Springer
ISBN: 3319676512
Category : Medical
Languages : en
Pages : 461
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Book Description
Bacterial Pathogens and their Virulence Factors contains a detailed description of 32 major bacterial pathogens that affect human health and their associated virulence determinants. Chapter 1 gives an overview of the different types and classes of general virulence factors involved in host cell adherence and invasion, dissemination within the host, host cell damage, and evasion of host defense systems, as well as mechanisms by which these virulence factors are regulated. Chapters 2 through 33 give concise descriptions of the disease states associated with the 32 bacterial genera and their major pathogenic species, along with an in-depth description of the individual virulence factors that have been found to be functionally involved in pathogenicity. A detailed bibliography derived from primary literature and review articles accompanies each of these chapters, allowing the reader to delve more deeply into individual pathogens and their virulence determinants. Chapter 34 discusses the exciting possibilities and initial successes of using detailed information on a pathogen’s virulence toolkit to design new therapeutics aimed at specific virulence traits.
Author: David Schlossberg
Publisher: Springer Science & Business Media
ISBN: 1468403052
Category : Medical
Languages : en
Pages : 226
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Book Description
Completely revised and updated, this comprehensive resource covers the epidemiology, pathogenesis, varied clinical manifestations, treatment and prevention of tuberculosis. All of the extra-pulmonary as well as pulmonary manifestations of tuberculosis are covered. Atypical mycobacterial infection is detailed. A special feature of this second edition is the new material on AIDS, which is now known to be complicated by tuberculosis infection.
