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Author: Alexander B. Poletaev
Publisher: Bentham Science Publishers
ISBN: 1608057240
Category : Medical
Languages : en
Pages : 254
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Book Description
The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. A considerable number of immune functions, including those related to antimicrobial defense, derive from autoclearance as well as construction and support of multicellularity. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonins), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the affected organ. Secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. Experimental and clinical production antibodies reveal antibodies against nuclear antigens, which penetrate into living cell nuclei and alter nuclear acid synthesis, cell proliferation and function. Autoantibodies can thus be regarded as hormone-like bioregulators of gene expression. The immune system is apparently able to reproduce complementary regulators for various cell receptors, including nuclear ones. The book focuses on physiological autoimmunity models and delves into the relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The E-book is a unique and comprehensive monograph and includes a history and contemporary research on natural autoimmunity - a fundamental concept essential for many branches of medicine and pathology. The concepts described in this e-book also have broad practical implications for the healthcare sector, because it establishes effective method of early prediction for many different diseases and creates a basis for prophylaxis. The reference gives medical and clinical professionals a chance to revisit old dogmas and acquire fruitful perspectives for theoretical reasoning and research planning.
Author: Alexander B. Poletaev
Publisher: Bentham Science Publishers
ISBN: 1608057240
Category : Medical
Languages : en
Pages : 254
Get Book Here
Book Description
The immune system is a natural component, regulator and direct participant in the physiological activities in a healthy body. A considerable number of immune functions, including those related to antimicrobial defense, derive from autoclearance as well as construction and support of multicellularity. Various pathological processes in any organ are usually accompanied by different patterns of cell death and, thus, by increased exposure and presentation of self antigens. These events induce the secondary rise in production of autoantibodies with appropriate specificity (opsonins), which provides augmentation of clearance by facilitating the efficacy of macrophage-dependent consumption of debris in the affected organ. Secondary changes in production and serum content of autoantibodies can be considered the universal and earliest detectable marker of any chronic disease. Experimental and clinical production antibodies reveal antibodies against nuclear antigens, which penetrate into living cell nuclei and alter nuclear acid synthesis, cell proliferation and function. Autoantibodies can thus be regarded as hormone-like bioregulators of gene expression. The immune system is apparently able to reproduce complementary regulators for various cell receptors, including nuclear ones. The book focuses on physiological autoimmunity models and delves into the relation between autoimmunity and autoallergy in the context of disease prevention and prediction. The E-book is a unique and comprehensive monograph and includes a history and contemporary research on natural autoimmunity - a fundamental concept essential for many branches of medicine and pathology. The concepts described in this e-book also have broad practical implications for the healthcare sector, because it establishes effective method of early prediction for many different diseases and creates a basis for prophylaxis. The reference gives medical and clinical professionals a chance to revisit old dogmas and acquire fruitful perspectives for theoretical reasoning and research planning.
Author: Carlo Perricone
Publisher: Academic Press
ISBN: 012814307X
Category : Medical
Languages : en
Pages : 728
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Book Description
The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.
Author: M. Eric Gershwin
Publisher: Academic Press
ISBN: 0128122420
Category : Medical
Languages : en
Pages : 1534
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Book Description
The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P's" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. - Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy - Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases - Keeps readers abreast of current trends and emerging areas in the field - Ensures that content is not only up-to-date, but applicable and relevant - Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy
Author: Yehuda Shoenfeld
Publisher: John Wiley & Sons
ISBN: 1118663438
Category : Science
Languages : en
Pages : 394
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Book Description
In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.
Author: Sudhir Gupta
Publisher: Springer Science & Business Media
ISBN: 1461512433
Category : Science
Languages : en
Pages : 138
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Book Description
Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies. This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists.
Author: Anthony S. Fauci
Publisher: McGraw Hill Professional
ISBN: 1259836282
Category : Medical
Languages : en
Pages : 357
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Book Description
Rheumatology – as only Harrison’s can cover it A Doody's Core Title for 2019! Featuring a superb compilation of chapters related to rheumatology derived from Harrison’s Principles of Internal Medicine, Nineteenth Edition (including content from the acclaimed Harrison’s DVD, now available here in print), this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find 24 chapters from more than 35 renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. FEATURES • Current, thorough coverage of important immunology and rheumatology topics, including the immune system in health and disease, disorders of immune-mediated injury, and disorders of the joints and adjacent tissues • Delivers insights designed to reduce pain, lesson joint and organ damage, and improve overall patient outcomes • Integrates pathophysiology with clinical management • High-yield board review questions make this text ideal for keeping current and preparing for the boards • Helpful appendix of laboratory values of clinical importance
Author: David G. Gardner
Publisher: McGraw Hill Professional
ISBN: 1259589293
Category : Medical
Languages : en
Pages : 941
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Book Description
A full-color guide to the entire field of clinical endocrinology and its scientific underpinnings – updated with the latest breakthroughs and developments A Doody’s Core Title for 2021! Greenspan’s Basic & Clinical Endocrinology delivers a succinct, leading-edge overview of the underlying molecular biology of the endocrine system and the latest perspectives on the diagnosis and treatment of specific diseases and disorders. Featuring an enhanced design that includes hundreds of full-color illustrations and clinical photographs, Greenspan’s is a true must-have during traditional or integrated courses in endocrinology, endocrinology rotation, or exam prep in internal medicine and endocrinology and as reference for disease management. Greenspan’s provides clinically relevant coverage of metabolic bone disease, pancreatic hormones and diabetes mellitus, hypoglycemia, obesity, geriatric endocrinology, and many other diseases and disorders. Supporting this essential material is a handy appendix of normal hormone reference ranges across the lifespan. Here’s why Greenspan’s is an essential tool for learning how to manage endocrine patients: • The Tenth Edition is enhanced by updated content throughout each chapter • NEW CHAPTERS on Transgender Endocrinology and Disorders of Sexual Determination and Differentiation • Important chapter on Evidence-Based Endocrinology and Clinical Epidemiology • Concise, balanced coverage of both scientific and clinical principles that guide patient management • The best source for current concepts in endocrine pathophysiology to aid clinical decision making • The most practical, current insights into diagnostic testing • More than 270 full-color illustrations and clinical photographs If you are in need of a well-illustrated, completely up-to-date guide to the entire field of clinical endocrinology, this trusted classic belongs on your desk or computer.
Author: Michael Laposata
Publisher: McGraw-Hill Education / Medical
ISBN: 9781260116793
Category : Medical
Languages : en
Pages : 592
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Book Description
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The acclaimed full-color guide to selecting the correct laboratory test and interpreting the results –- covering ALL of clinical pathology Laboratory Medicine is the most comprehensive, user-friendly, and well-illustrated guide available for learning how to order the correct laboratory test and understand the clinical significance of the results. The book features an easy-to-follow, consistent presentation for each disease discussed. Chapters begin with a brief description of the disorder followed by a discussion that includes tables detailing the laboratory evaluation of specific disorders, diagnosis, baseline tests to exclude diagnostic possibilities, and clinical indications that warrant further screening and special testing. With new, increasingly expensive and complicated tests appearing almost daily, Laboratory Medicine, Third Edition is required reading for medical students, clinical laboratory scientists, and healthcare professionals who want to keep abreast of the latest testing procedures and maximize accuracy and patient safety. Features: •48 clinical laboratory methods presented in easy-to-understand illustrations that include information on the expense and complexity of the assays •More than 200 tables and full-color algorithms that encapsulate important information and facilitate understanding •Full-color blood-smear micrographs that demonstrate common abnormal morphologies of red blood cells •Valuable learning aids in each chapter, including learning objectives, chapter outlines, and a general introduction -- and new to this edition: chapter-ending self-assessment Q&A•Logical systems-based organization that complements most textbooks •Extensive table of Clinical Laboratory Reference Values that show the conversions between U.S. and SI units for each value
Author: Prof Dr Mike KS Chan
Publisher: EUROPEAN WELLNESS ACADEMY
ISBN: 1662930216
Category : Medical
Languages : en
Pages : 607
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Book Description
This handbook focuses on different aspects of anti-aging and both preventive and regenerative medicine. It includes analysis of the paradigm of ageing and concepts of anti-aging medicine. Standards and technologies are highlighted in over twenty chapters all authored by international experts in regenerative medicine. Topics covered include: • Ageing, aging, and anti-aging: A Decalogue for anti-aging medicine • Lessons from Sicilian centenarians for anti-aging medicine • Molecular biomarkers and genetic aspects of aging • Future of peptides in clinical practice • Mitochondrial approaches in anti-aging medicine and in SARS-CoV2 infection • Tissue-specific autoantibodies in preventive medicine • Chronic stress as a psycho-neuro-immunological dysfunction • Gut-associated immune system and its health implications • Regenerative medicine with platelet-rich-plasma • Alzheimer’s disease: Preventive and anti-aging neurology • Autistic spectrum disorder and mitochondrial medicine • Integrative hormonal approach in anti-aging medicine • Preventive cardiology and phlebology • Aesthetic and anti-aging medicine • Preventive ophthalmology • Preventive oncology • Nutrition in healthy aging • Physical activity and fitness paradigms for anti-aging and longevity Recommended reading for clinicians working in anti-aging medicine as well as ageing people. The authors hope it will set a new “standard of anti-aging medicine” and as a tool in planning for the inevitable challenges we all will face caring for ageing patients and creating preventive-health programs.
Author: Nima Rezaei
Publisher: Academic Press
ISBN: 0323859763
Category : Medical
Languages : en
Pages : 460
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Book Description
As the autoimmune diseases could affect different organs, Translational Autoimmunity: Autoimmune Diseases in Different Organs addresses the spectrum of autoimmune diseases. The fourth volume of Translational Immunology Series focuses on clinical and laboratory details of autoimmune diseases which are broadly categorized into two types of organ-specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases). Autoimmune rheumatic diseases such as systemic lupus erythematosus and rheumatoid arthritis, autoimmune rheumatic diseases such as diabetes mellitus and thyroid diseases, autoimmune neurologic diseases such as multiple sclerosis, as well as autoimmune hepatobiliary diseases, autoimmune renal diseases and autoimmune cutaneous diseases as the subject of discussion in Translational Autoimmunity: Autoimmune Diseases in Different Organs. - Comprises major parts that cover basic immunology, clinical aspects of autoimmunity, and translational immunology studies in autoimmunity - Each and every key concept will be mentioned after an easy background is drawn and then, will be supported by a systematic appraisal of the most recent evidence - Can help students at all the academic levels while applicable to scientists who work with autoimmunity - Designed for learning, teaching, review and testing, practice, and research. Hence, it might be useful for students, teachers and instructors, physicians, and researchers
