Bulletin of the Atomic Scientists PDF Download
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 88
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Book Description
The Bulletin of the Atomic Scientists is the premier public resource on scientific and technological developments that impact global security. Founded by Manhattan Project Scientists, the Bulletin's iconic "Doomsday Clock" stimulates solutions for a safer world.
Author: Peter V E McClintock
Publisher: Mdpi AG
ISBN: 9783036516462
Category : Science
Languages : en
Pages : 306
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Book Description
The book reprints a set of important scientific papers applying physics and mathematics to address the problem of selective ionic conduction in narrow water-filled channels and pores. It is a long-standing problem, and an extremely important one. Life in all its forms depends on ion channels and, furthermore, the technological applications of artificial ion channels are already widespread and growing rapidly. They include desalination, DNA sequencing, energy harvesting, molecular sensors, fuel cells, batteries, personalised medicine, and drug design. Further applications are to be anticipated. The book will be helpful to researchers and technologists already working in the area, or planning to enter it. It gives detailed descriptions of a diversity of modern approaches, and shows how they can be particularly effective and mutually reinforcing when used together. It not only provides a snapshot of current cutting-edge scientific activity in the area, but also offers indications of how the subject is likely to evolve in the future.
Author: E.V. Mielczarek
Publisher: Springer Science & Business Media
ISBN: 9780883188552
Category : Science
Languages : en
Pages : 450
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Book Description
Market: Students and researchers in biological physics. "Any medical
Author: Shin-Ho Chung
Publisher: Springer Science & Business Media
ISBN: 0387689192
Category : Science
Languages : en
Pages : 657
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Book Description
This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Author:
Publisher:
ISBN:
Category : Physics
Languages : en
Pages : 1256
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Book Description
Author: Michael Nastasi
Publisher: Cambridge University Press
ISBN: 052137376X
Category : Science
Languages : en
Pages : 572
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Book Description
Comprehensive guide to an important materials science technique for students and researchers.
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Category : Aeronautics
Languages : en
Pages : 308
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Book Description
Author: Inka Sastalla
Publisher: Frontiers Media SA
ISBN: 2889199916
Category : Immunologic diseases. Allergy
Languages : en
Pages : 192
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Book Description
Bacterial pathogenicity factors are functionally diverse. They may facilitate the adhesion and colonization of bacteria, influence the host immune response, assist spreading of the bacterium by e.g. evading recognition by immune cells, or allow bacteria to dwell within protected niches inside the eukaryotic cell. Exotoxins can be single polypeptides or heteromeric protein complexes that act on different parts of the cells. At the cell surface, they may insert into the membrane to cause damage; bind to receptors to initiate their uptake; or facilitate the interaction with other cell types. For example, bacterial superantigens specifically bind to major histocompatibility complex (MHC) II molecules on the surface of antigen presenting cells and the T cell receptor, while cytolysins cause pore formation. For intracellular activity, exotoxins need to be translocated across the eukaryotic membrane. Gram-negative bacteria can directly inject effector proteins in a receptor-independent manner by use of specialized needle apparatus such as bacterial type II, III, or type IV secretion systems. Other methods of translocation include the phagocytic uptake of bacteria followed by toxin secretion, or receptor-mediated endocytosis which allows the targeting of distinct cell types. Receptor-based uptake is initiated by the binding of heteromeric toxin complexes to the cell surface and completed by the translocation of the effector protein(s) across the endosomal membrane. In the cytosol, toxins interact with specific eukaryotic target proteins to cause post-translational modifications that often result in the manipulation of cellular signalling cascades and inflammatory responses. It has become evident that the actions of some bacterial toxins may exceed their originally assumed cytotoxic function. For example, pore-forming toxins do not only cause cytolysis, but may also induce autophagy, pyroptosis, or activation of the MAPK pathways, resulting in adjustment of the host immune response to infection and modification of inflammatory responses both locally and systemically. Other recently elucidated examples of the immunomodulatory function of cell death-inducing exotoxins include TcdB of Clostridium difficile which activates the inflammasome through modification of cellular Rho GTPases, or the Staphyloccocus d-toxin which activates mast cells. The goal of this research topic was to gather current knowledge on the interaction of bacterial exotoxins and effector proteins with the host immune system. The following 16 research and review articles in this special issue describe mechanisms of immune modification and evasion and provide an overview over the complexity of bacterial toxin interaction with different cells of the immune system.
Author: Chao Huang
Publisher: John Wiley & Sons
ISBN: 1119507553
Category : Science
Languages : en
Pages : 47
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Book Description
A comprehensive review of global ionospheric research from the polar caps to equatorial regions It's more than a century since scientists first identified the ionosphere, the layer of the Earth’s upper atmosphere that is ionized by solar and cosmic radiation. Our understanding of this dynamic part of the near-Earth space environment has greatly advanced in recent years thanks to new observational technologies, improved numerical models, and powerful computing capabilities. Ionosphere Dynamics and Applications provides a comprehensive overview of historic developments, recent advances, and future directions in ionospheric research. Volume highlights include: Behavior of the ionosphere in different regions from the poles to the equator Distinct characteristics of the high-, mid-, and low-latitude ionosphere Observational results from ground- and space-based instruments Ionospheric impacts on radio signals and satellite operations How earthquakes and tsunamis on Earth cause disturbances in the ionosphere The American Geophysical Union promotes discovery in Earth and space science for the benefit of humanity. Its publications disseminate scientific knowledge and provide resources for researchers, students, and professionals. Find out more about the Space Physics and Aeronomy collection in this Q&A with the Editors in Chief
Author: Stuart A. Rice
Publisher: John Wiley & Sons
ISBN: 1118158709
Category : Science
Languages : en
Pages : 521
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Book Description
The Advances in Chemical Physics series—the cutting edge of research in chemical physics The Advances in Chemical Physics series provides the chemical physics and physical chemistry fields with a forum for critical, authoritative evaluations of advances in every area of the discipline. Filled with cutting-edge research reported in a cohesive manner not found elsewhere in the literature, each volume of the Advances in Chemical Physics series offers contributions from internationally renowned chemists and serves as the perfect supplement to any advanced graduate class devoted to the study of chemical physics. This volume explores: Control of Quantum Phenomena (Constantin Brif, Raj Chakrabarti, and Herschel Rabitz) Crowded Charges in Ion Channels (Bob Eisenberg) Colloidal Crystallization Between Two and Three Dimensions (H. Löwen, E.C. Oguz, L. Assoud, and R. Messina) Statistical Mechanics of Liquids and Fluids in Curved Space (Gilles Tarjus, FranÇois Sausset, and Pascal Viot)
Author: Armin Kargol
Publisher: Morgan & Claypool Publishers
ISBN: 1643277561
Category : Science
Languages : en
Pages : 107
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Book Description
All living matter is comprised of cells, small compartments isolated from the environment by a cell membrane and filled with concentrated solutions of various organic and inorganic compounds. Some organisms are single-cell, where all life functions are performed by that cell. Others have groups of cells, or organs, specializing in one particular function. The survival of the entire organism depends on all of its cells and organs fulfilling their roles. While the cells are studied by different sciences, they are seen differently by biologists, chemists, or physicists. Biologists concentrate their attention on cell structure and function. What the cells consists of? Where are its organelles? What function each organelle fulfils? From a chemists’ point of view, a cell is a complex chemical reaction chamber where various molecules are synthesized or degraded. The main question is how these, sometimes very complicated chains of reactions are controlled. Finally, from a physics standpoint, some of the fundamental questions are about the physical movement of all these molecules between organelles within the cell, their exchange with the extracellular medium, as well as electrical phenomena resulting from such transport. The aim of this book is to look into the basic physical phenomena occurring in cells. These physical transport processes facilitate chemical reactions in the cell and various electrical effects, and that in turn leads to biological functions necessary for the cell to satisfy its role in the mother organism. Ultimately, the goals of every cell are to stay alive and to fulfill its function as a part of a larger organ or organism. The first volume of this book is an inventory of physical transport processes occurring in cells while this second volume provides a closer look at how complex biological and physiological cell phenomena result from these very basic physical processes.
