Phosphorylation of Initiation Factor EIF-2, Binding of MRNA to 48S Complexes and Its Reutilization in Initiation of Protein Synthesis PDF Download
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Author: Arrigo De Benedetti
Publisher:
ISBN:
Category : Phosphorylation
Languages : en
Pages : 60
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Book Description
Author: Arrigo De Benedetti
Publisher:
ISBN:
Category : Phosphorylation
Languages : en
Pages : 60
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Author: Nahum Sonenberg
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 1040
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Book Description
There is fresh interest in protein synthesis and recognition of the key role of translational control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the 1996 publication, Translational Control, but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.
Author: Heinz Herrmann
Publisher: HarperCollins Publishers
ISBN:
Category : Science
Languages : en
Pages : 936
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1142
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Author: Federation of American Societies for Experimental Biology
Publisher:
ISBN:
Category : Biochemistry
Languages : en
Pages : 1020
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Author: Swati Joshi-Barve
Publisher:
ISBN:
Category :
Languages : en
Pages : 228
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Author: Michael J. Clemens
Publisher: CRC Press
ISBN: 9789057020308
Category : Medical
Languages : en
Pages : 300
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Book Description
The aim of this text is to integrate the processes of protein phosphorylation and dephosphorylation into the complex pathways by which cellular proliferation is driven, bringing together the many different systems of control implicated in the regulation of cell growth. Presents a survey of protein phosphorylation roles in the control of cellular proliferation and differentiation. A large number of protein kinases and phosphatases have been characterised in higher cells, and have been shown to be involved in signal transduction pathways by which growth factors, mitogens, and extracellular agents exert proliferative effects on cells. Important subjects covered include control of gene expression at the transcriptional and translational levels, and roles of the cdk kinases and cyclins in cell cycles regulation. Describes all major families of protein kinases of significance to growth regulation.
Author: George Stamatoyannopoulos
Publisher: W.B. Saunders Company
ISBN:
Category : Medical
Languages : en
Pages : 776
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Author: John Leonard Fakunding
Publisher:
ISBN:
Category :
Languages : en
Pages : 312
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The initiation of the synthesis of proteins is a fundamental process shared by all living organisms. Each organism has both shared and unique mechanisms for regulation of this vital process. Higher plants provide for a major amount of fixation of carbon from the environment and turn this carbon into food and fuel sources for our use. However, we have very little understanding of how plants regulate the synthesis of the proteins necessary for these metabolic processes. The research carried out during the grant period sought to address some of these unknowns in the regulation of protein synthesis initiation. Our first goal was to determine if phosphorylation plays a significant role in plant initiation of protein synthesis. The role of phosphorylation, although well documented in mammalian protein synthesis regulation, is not well studied in plants. We showed that several of the factors necessary for the initiation of protein synthesis were targets of plant casein kinase and showed differential phosphorylation by the plant specific isoforms of this kinase. In addition, we identified and confirmed the phosphorylation sites in five of the plant initiation factors. Further, we showed that phosphorylation of one of these factors, eIF5, affected the ability of the factor to participate in the initiation process. Our second goal was to develop a method to make initiation factor 3 (eIF3) using recombinant methods. To date, we successfully cloned and expressed 13/13 subunits of wheat eIF3 in E. coli using de novo gene construction methods. The final step in this process is to place the subunits into three different plasmid operons for co-expression. Successful completion of expression of eIF3 will be an invaluable tool to the plant translation community.
