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Author: G. Brian Wisdom
Publisher: IRL Press
ISBN:
Category : Medical
Languages : en
Pages : 280
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Book Description
Peptide antigens and their antibodies have been widely exploited for the measurement, location, and purification of oligopeptides such as peptide hormones. Recently, the use of peptides to mimic substructures of proteins has led to major expansion in the application of anti-peptide antibodies. These have been especially important in identifying the characterizing proteins which are only known by their primary structure derived from a DNA sequence. Another area of recent expansion is the use of defined peptided antigens to identify and map antibodies and T-cell receptors. This book provides information and detailed protocols for the main techniques for exploitation of peptide antigens and anti-peptide antibodies, and will interest research workers in many fields.
Author: G. Brian Wisdom
Publisher: IRL Press
ISBN:
Category : Medical
Languages : en
Pages : 280
Get Book
Book Description
Peptide antigens and their antibodies have been widely exploited for the measurement, location, and purification of oligopeptides such as peptide hormones. Recently, the use of peptides to mimic substructures of proteins has led to major expansion in the application of anti-peptide antibodies. These have been especially important in identifying the characterizing proteins which are only known by their primary structure derived from a DNA sequence. Another area of recent expansion is the use of defined peptided antigens to identify and map antibodies and T-cell receptors. This book provides information and detailed protocols for the main techniques for exploitation of peptide antigens and anti-peptide antibodies, and will interest research workers in many fields.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: S. Muller
Publisher: Elsevier
ISBN: 008085897X
Category : Medical
Languages : en
Pages : 401
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Book Description
This newest edition to the Laboratory Techniques Series gives current state of the art use of synthetic peptides in molecular biology and practical protocols on how to conjugate peptides, immunize animals with peptides and monitor immune responses to peptides in vitro. It gives background information on antigenic specificity, prediction of antigenic sites in proteins and applications of peptides in immunology and virology, as probes in diagnosis and as vaccines. The book also describes antigenicity of proteins and methods to localize antigenic sites as well as methods for predicting epitoxes, and gives detailed protocols for peptide-carrier conjugation, immunization with peptides, and peptide immunoassays. The volume also describes typical use of antipeptide antibodies in molecular and cellular biology as well as the use of peptides in the diagnosis of viral infections and autoimmune diseases, and the use of peptides as potential synthetic vaccines. An excellent edition to an excellent series, available in hardbound and paperback.
Author: M. Z. Atassi
Publisher: Springer Science & Business Media
ISBN: 1468479741
Category : Medical
Languages : en
Pages : 278
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Book Description
This symposia series, founded in 1976, is devoted to the advancement and dissemination of knowledge in the field in immunology, particularly as it relates to the immune recognition and responses to protein and peptide antigens. Leading investigators are convened every 2 or 3 years for the purpose of consolidating the research on protein and peptide antigens of defined structure and to focus on these findings in the context of contemporary immunology. Each symposium has focussed on a particular aspect of molecular and cellular immunology of proteins and peptides. It is extremely gratifying that, in the last 2-3 years, the scientific community has shown a heightened interest in the study and understanding of protein and peptide antigens. The third symposium was devoted to viral and bacterial antigens. Great advances have been made in recent years in the elucidation and synthesis of protein antigenic sites. These, together with advances in cloning, expression and sequencing of protein genes, have offered new avenues for the preparation of synthetic vaccines for viral, bacterial and other antigens. Such vaccines have been the aspiration of immunologists for over 20 years. The meeting has served to integrate and correlate the current knowledge of these systems with developing trends in immunology and to identify the most promising new directions for future investigations.
Author: Hilary Koprowski
Publisher: Springer Science & Business Media
ISBN: 3642714404
Category : Medical
Languages : en
Pages : 93
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Book Description
The humoral response of the immune system to a foreign antigen usually requires the recognition of two antigenic determinants. The one, called the carrier, is recognized by T-Iymphocytes, the other, called the hapten, by B-Iympho cytes. As a consequence, T - and B-Iymphocytes proliferate, B-Iymphocytes produce hapten-specific antibodies, and the system develops memory to the antigens. It was long thought that antigens would form a bridge to mediate the cooperation of T - and B-Iymphocytes. However, it now appears that antigens are broken down to fragments which then act as carrier determinants for T -lymphocytes. The cells which originally process antigen are called an tigen-presenting cells. They have phagocytic properties. They can take up and degrade antigens, in the case of pro teins to peptides. The peptides of protein antigens reappear on the surface of the antigen-presenting cells, where they must become associated with membrane proteins encoded by genes of the major histocompatibility complex (MHC) in order to be recognized by T-Iymphocytes. To activate helper T-Iym phocytes which cooperate in antibody responses, MHC class II molecules have to be expressed on the surface of the antigen-presenting cells. Once T -lymphocytes have be come activated, they are ready to cooperate with B cells.
Author: J.P. Briand
Publisher: Elsevier
ISBN: 9780080858883
Category : Medical
Languages : en
Pages : 226
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Book Description
Synthetic Polypeptides as Antigens is the first volume to give a comprehensive treatment under one cover of the various techniques used for synthesizing peptides by the solid phase approach, for coupling them to carrier molecules and analyzing their immunochemical activity by a variety of immunoassays. This book also describes methods for analyzing the antigenic structure of proteins and predicting the location of their antigenic sites. Recent advances in the detection of gene products with antipeptide antibodies, and the still controversial use of synthetic peptides as vaccines are also described. The book provides: - detailed descriptions of procedures - extensive bibliography - detailed analysis of the structural basis of antigenicity in proteins Synthetic Polypeptides as Antigens is intended for researchers and graduate students in molecular biology, protein structure, immunology, virology, and microbiology. Those using synthetic peptides as immunological probes will find this a most useful book, as will those wishing to overcome the difficulties of achieving antigenic mimicry by synthesis.
Author: M. Zouhair Atassi
Publisher: Springer Science & Business Media
ISBN: 1468454420
Category : Medical
Languages : en
Pages : 332
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Book Description
This symposium was established in 1976 for the purpose of bringing to gether once every two or three years, active investigators in the fore front of contemporary immunology, to present their findings and to discuss their significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the under standing of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptides which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has finally occurred and many applications of these peptides are now being realized. The main symposia topics of the fourth symposium were: T-cell recognition of proteins, structure and function of the T-cell receptor, presentation of protein antigens, recycling and activation of membrane receptor molecules, Ir-gene control of T-cell responses and methods of cell separation. The molecular features recognized by antibodies on proteins were the first immune recognition sites to be local ized and confirmed by synthetic peptides. The complete antigenic structures of several proteins have been defined, and individual antigenic sites have been described on many more proteins. More recently, major breakthroughs have been reported in the immune recognition of proteins by T cells.
Author: N. D. Zegers
Publisher: CRC Press
ISBN: 9780849389672
Category : Medical
Languages : en
Pages : 498
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Book Description
Immunological Recognition of Peptides in Medicine and Biology gives a state-of-the-art overview on the use of peptides and peptide-ligand interactions, and the critical role they play in recognition patterns for the regulation of various biological functions. A wide range of applications are discussed, including some experimental preclinical ones such as epitope mapping, peptide libraries, and production of amino acid-specific antibodies and their therapeutic use in oncology and infectious disease vaccines. Each chapter also includes step-by-step protocols to aid in actual experiments. Several alternative techniques and strategies are discussed by different authors offering the reader an opportunity to select the most favorable application for a specific biological problem.
Author:
Publisher: Academic Press
ISBN: 0080582222
Category : Medical
Languages : en
Pages : 561
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Book Description
Topics Covered Include: X-ray crystallography of ligands. Catalytic antibodies. Nature of the antigen. Antibody binding sites. Maturation of the immune response. Computational biochemistry of antibodies and T-cell receptors. Antigen-specific T-cell receptors and their reactions. Key Features* X-Ray Crystallography of Ligands* Catalytic Antibodies* Nature of the Antigen* Antibody Binding Sites* Maturtion of the Immune Response* Computational Biochemistry of Antibodies and * T-Cell Receptors* Antigen-Specific T-Cell Receptors and Their Reactions
