Pathophysiologic Effects of Stable Iodine Used as a Thyroidal Blocking Agent to Reduce Thyroid Radiation Exposure. Progress Report, November 1, 1975--October 31, 1976. [/sup 125/I Tracer Technique]

Pathophysiologic Effects of Stable Iodine Used as a Thyroidal Blocking Agent to Reduce Thyroid Radiation Exposure. Progress Report, November 1, 1975--October 31, 1976. [/sup 125/I Tracer Technique] PDF Author:
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ISBN:
Category :
Languages : en
Pages :

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In an effort to determine whether iodide administration in man can induce injury to thyroid follicular cells similar to that demonstrated in lower animals, this study measures thyroglobulin, thyroxine and triiodothyronine and thyroid autoantibodies in the serum before and after administration of iodine in a variety of patients. In the last eight months primary efforts have been devoted to the development of a high specificity and sensitivity radioimmunoassay of thyroglobulin and its preliminary clinical application. Human thyroglobulin obtained from operative specimens was purified and its identity and purity established. Rabbits were injected with thyroglobulin for 30 weeks with the appearance of significant titres of antibodies within 6 weeks. The antibody developed was examined for immunological purity and used in a radioimmunoassay system with thyroglobulin labeled in this Laboratory with /sup 125/I.

Pathophysiologic Effects of Stable Iodine Used as a Thyroidal Blocking Agent to Reduce Thyroid Radiation Exposure. Progress Report, November 1, 1975--October 31, 1976. [/sup 125/I Tracer Technique]

Pathophysiologic Effects of Stable Iodine Used as a Thyroidal Blocking Agent to Reduce Thyroid Radiation Exposure. Progress Report, November 1, 1975--October 31, 1976. [/sup 125/I Tracer Technique] PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description
In an effort to determine whether iodide administration in man can induce injury to thyroid follicular cells similar to that demonstrated in lower animals, this study measures thyroglobulin, thyroxine and triiodothyronine and thyroid autoantibodies in the serum before and after administration of iodine in a variety of patients. In the last eight months primary efforts have been devoted to the development of a high specificity and sensitivity radioimmunoassay of thyroglobulin and its preliminary clinical application. Human thyroglobulin obtained from operative specimens was purified and its identity and purity established. Rabbits were injected with thyroglobulin for 30 weeks with the appearance of significant titres of antibodies within 6 weeks. The antibody developed was examined for immunological purity and used in a radioimmunoassay system with thyroglobulin labeled in this Laboratory with /sup 125/I.

Pathophysiologic Effects of Stable Iodine Used as a Thyroidal Blocking Agent to Reduce Thyroid Radiation Exposure. Final Progress Report, November 1, 1976--December 31, 1977

Pathophysiologic Effects of Stable Iodine Used as a Thyroidal Blocking Agent to Reduce Thyroid Radiation Exposure. Final Progress Report, November 1, 1976--December 31, 1977 PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description
In order to determine whether acute administration of iodide leads to any undesirable effects in the general population, we studied a group of patients who received iodinated radiographic contrast medium in the course of routine x-ray diagnostic procedures. We were particularly interested in investigating the possibility that administration of iodine could damage thyroid follicular cells leading to release of intrathyroidal antigens such as thyroglobulin into the blood. An increase in serum thyroglobulin might, in turn, either initiate or exacerbate thyroid autoimmunity in susceptible individuals, leading to autoimmune thyroiditis. We looked for undesirable effects due to the administration of iodide in 3 ways: a possible acute toxic effect on thyroid follicular cells was investigated by determining serum thyroglobulin immediately prior to and 24 hours after injection of iodinated contrast medium; an effect on thyroid autoimmunity was investigated by determining thyroid autoantibodies immediately prior to and 3 to 6 months after injection of iodinated contrast medium; and acute and chronic effects on thyroid function were investigated by performing thyroid function tests immediately prior to, 24 hours after and 3 to 6 months after injection of iodinateed contrast medium.

TID.

TID. PDF Author:
Publisher:
ISBN:
Category : Energy development
Languages : en
Pages : 676

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Low-level Radiation

Low-level Radiation PDF Author: United States. Department of Energy. Technical Information Center
Publisher:
ISBN:
Category : Radiation
Languages : en
Pages : 740

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Energy Research Abstracts

Energy Research Abstracts PDF Author:
Publisher:
ISBN:
Category : Power resources
Languages : en
Pages : 668

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Effects of Stable Iodide Blocking of Exposure to Radioiodine. Progress Report, November 1, 1974--October 31, 1975

Effects of Stable Iodide Blocking of Exposure to Radioiodine. Progress Report, November 1, 1974--October 31, 1975 PDF Author:
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Category :
Languages : en
Pages :

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Results are reported from studies on the influence of dietary iodine intake on the uptake of $sup 131$I by the thyroid gland of beagles. A model of iodine kinetics in normal dogs was developed that consists of separate subsystems for iodine, thyroxine, triiodothyronine, and the thyroid gland. The model demonstrates important differences in iodine metabolism and thyroid function between the dog and man. (CH).

INIS Atomindeks

INIS Atomindeks PDF Author:
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ISBN:
Category : Nuclear energy
Languages : en
Pages : 1104

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Essentials of Nuclear Medicine Science

Essentials of Nuclear Medicine Science PDF Author: William B. Hladik
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 472

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Fundamentals of Nuclear Pharmacy

Fundamentals of Nuclear Pharmacy PDF Author: Gopal B. Saha
Publisher: Springer
ISBN: 3319575805
Category : Medical
Languages : en
Pages : 430

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Book Description
Currently an estimated 17 million nuclear medicine procedures are performed each year in the US and constantly evolving, as new radiopharmaceuticals and imaging techniques are introduced for better diagnosis and treatment of human diseases. In keeping up with new developments, the Seventh Edition of Fundamentals of Nuclear Pharmacy chronicles the advancements in radiopharmaceuticals and their use in clinical applications. It discusses basic concepts such as the atom, radioactive decay, instrumentation and production of radionuclides, and explores the design, labeling, characteristics and quality control of radiopharmaceuticals. Radiation regulations and diagnostic and therapeutic applications of radiopharmaceuticals are detailed. Thoroughly updated, the Seventh Edition includes new topics such as alternative productions of 99Mo; production of 64Cu, 86Y, 89Zr, 177Lu, 223Ra; synthesis and clinical uses of new radiopharmaceuticals such as DaTscan, Xofigo, Amyvid, Neuraceq, Vizamyl, Axumin and 68Ga-DOTATATE; dosimetry of new radiopharmaceuticals; theranostic agents and translational medicine. It features numerous examples, diagrams, and images to further clarify the information and offers end- of-chapter questions to help readers assess their comprehension of the material. Recognized as a classic text on nuclear chemistry and pharmacy and acclaimed for its concise and easy-to-understand presentation, Fundamentals of Nuclear Pharmacy is an authoritative resource for nuclear medicine physicians, residents, students, and technologists.

Clinical Endocrinology of Dogs and Cats

Clinical Endocrinology of Dogs and Cats PDF Author: A. Rijnberk
Publisher: Springer Science & Business Media
ISBN: 9400901054
Category : Medical
Languages : en
Pages : 245

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Book Description
Clinical endocrinology is a fascinating field requiring the challenging combination of broad pathophysiological interest and specific expertise in the field of endocrinology, thereby occupying a common ground between biochemistry, physiology and clinical medicine. In the majority of cases the clinician's notion of the presence of an endocrine disease is largely based upon pattern recognition, in which physical changes play an important role. Therefore many color illustrations have been included throughout the text. In addition there are many full color graphs and illustrations of diagnostic imaging and pathology. With over 350 illustrations the book represents a richly illustrated text on the diseases of endocrine glands. For each gland there is an introductory section on the relevant morphology and physiology, followed by descriptions of the disorders of the gland. When endocrine diseases are quite different in dogs and cats, separate descriptions are given for these species. Protocols for function tests and emergency treatments are presented in the last chapters. Consequently the book provides the user with both comprehensive descriptions and quick references. The book has been written by leading clinicians in the field, with contributions from two biochemists, a radiologist and pathologist. As such a valuable textbook for veterinary students and practitioners has been compiled to fulfil the need for an up-to-date and complete book on endocrine diseases of dogs and cats.