Author: Chongyang Liu
Publisher: Springer
ISBN: 3662437937
Category : Mathematics
Languages : en
Pages : 191
Book Description
The book presents, in a systematic manner, the optimal controls under different mathematical models in fermentation processes. Variant mathematical models – i.e., those for multistage systems; switched autonomous systems; time-dependent and state-dependent switched systems; multistage time-delay systems and switched time-delay systems – for fed-batch fermentation processes are proposed and the theories and algorithms of their optimal control problems are studied and discussed. By putting forward novel methods and innovative tools, the book provides a state-of-the-art and comprehensive systematic treatment of optimal control problems arising in fermentation processes. It not only develops nonlinear dynamical system, optimal control theory and optimization algorithms, but can also help to increase productivity and provide valuable reference material on commercial fermentation processes.
Optimal Control of Switched Systems Arising in Fermentation Processes
Author: Chongyang Liu
Publisher: Springer
ISBN: 3662437937
Category : Mathematics
Languages : en
Pages : 191
Book Description
The book presents, in a systematic manner, the optimal controls under different mathematical models in fermentation processes. Variant mathematical models – i.e., those for multistage systems; switched autonomous systems; time-dependent and state-dependent switched systems; multistage time-delay systems and switched time-delay systems – for fed-batch fermentation processes are proposed and the theories and algorithms of their optimal control problems are studied and discussed. By putting forward novel methods and innovative tools, the book provides a state-of-the-art and comprehensive systematic treatment of optimal control problems arising in fermentation processes. It not only develops nonlinear dynamical system, optimal control theory and optimization algorithms, but can also help to increase productivity and provide valuable reference material on commercial fermentation processes.
Publisher: Springer
ISBN: 3662437937
Category : Mathematics
Languages : en
Pages : 191
Book Description
The book presents, in a systematic manner, the optimal controls under different mathematical models in fermentation processes. Variant mathematical models – i.e., those for multistage systems; switched autonomous systems; time-dependent and state-dependent switched systems; multistage time-delay systems and switched time-delay systems – for fed-batch fermentation processes are proposed and the theories and algorithms of their optimal control problems are studied and discussed. By putting forward novel methods and innovative tools, the book provides a state-of-the-art and comprehensive systematic treatment of optimal control problems arising in fermentation processes. It not only develops nonlinear dynamical system, optimal control theory and optimization algorithms, but can also help to increase productivity and provide valuable reference material on commercial fermentation processes.
Fed-Batch Cultures
Author: Henry C. Lim
Publisher: Cambridge University Press
ISBN: 1107328128
Category : Technology & Engineering
Languages : en
Pages : 477
Book Description
Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.
Publisher: Cambridge University Press
ISBN: 1107328128
Category : Technology & Engineering
Languages : en
Pages : 477
Book Description
Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.
Batch Fermentation
Author: Ali Cinar
Publisher: CRC Press
ISBN: 9780203911358
Category : Science
Languages : en
Pages : 658
Book Description
Illustrating techniques in model development, signal processing, data reconciliation, process monitoring, quality assurance, intelligent real-time process supervision, and fault detection and diagnosis, Batch Fermentation offers valuable simulation and control strategies for batch fermentation applications in the food, pharmaceutical, and chemical industries. The book provides approaches for determining optimal reference trajectories and operating conditions; estimating final product quality; modifying, adjusting, and enhancing batch process operations; and designing integrated real-time intelligent knowledge-based systems for process monitoring and fault diagnosis.
Publisher: CRC Press
ISBN: 9780203911358
Category : Science
Languages : en
Pages : 658
Book Description
Illustrating techniques in model development, signal processing, data reconciliation, process monitoring, quality assurance, intelligent real-time process supervision, and fault detection and diagnosis, Batch Fermentation offers valuable simulation and control strategies for batch fermentation applications in the food, pharmaceutical, and chemical industries. The book provides approaches for determining optimal reference trajectories and operating conditions; estimating final product quality; modifying, adjusting, and enhancing batch process operations; and designing integrated real-time intelligent knowledge-based systems for process monitoring and fault diagnosis.
Computer Control of Fermentation Processes
Author: Daniel R. Omstead
Publisher: CRC Press
ISBN: 1000141756
Category : Computers
Languages : en
Pages : 362
Book Description
The purpose of this volume is to describe the components, assembly, and implementation of computer-based process control systems. Presented in two sections, it illustrates how such systems have been used to monitor and control industrial fermentation processes as a means to improve our understanding of product biosynthesis. This book covers the fields of indirect parameter estimation and fermentation-specific control algorithms. It also includes chapters which describe system architecture and process application, process control, on-line liquid sampling and computer system architecture. This is an ideal source for anyone involved with biotechnology, bioengineering, microbial technology, chemical engineering, and computer control.
Publisher: CRC Press
ISBN: 1000141756
Category : Computers
Languages : en
Pages : 362
Book Description
The purpose of this volume is to describe the components, assembly, and implementation of computer-based process control systems. Presented in two sections, it illustrates how such systems have been used to monitor and control industrial fermentation processes as a means to improve our understanding of product biosynthesis. This book covers the fields of indirect parameter estimation and fermentation-specific control algorithms. It also includes chapters which describe system architecture and process application, process control, on-line liquid sampling and computer system architecture. This is an ideal source for anyone involved with biotechnology, bioengineering, microbial technology, chemical engineering, and computer control.
2nd International Workshop on Practical Applications of Computational Biology and Bioinformatics (IWPACBB 2008)
Author: Juan Manuel Corchado Rodríguez
Publisher: Springer Science & Business Media
ISBN: 354085861X
Category : Technology & Engineering
Languages : en
Pages : 265
Book Description
The success of Bioinformatics in recent years has been prompted by research in mole- lar biology and medicine in initiatives like the human genome project. The volume and diversification of data has increased so much that it is very hard if not impossible to analyze it by human experts. The analysis of this growing body of data, intensified by the development of a number of high-throughput experimental techniques that are generating the so called 'omics' data, has prompted for new computational methods. New global approaches, such as Systems Biology, have been emerging replacing the reductionist view that dominated biology research in the last decades, requiring the coordinated efforts of biological researchers with those related to data analysis, mathematical modelling and computer science. Computational methods have been helping in tasks related to knowledge discovery, modelling and optimization tasks. This workshop brings the opportunity to discuss applications of Bioinformatics and Computational Biology exploring the interactions between computer scientists, bio- gists and other scientific researchers. The IWPACBB technical program includes 29 papers (23 long papers and 6 short papers) selected from a submission pool of 51 papers, from 9 different countries. We thank the excellent work of the local organization members and also from the members of the Program Committee for their excellent reviewing work. October 2008 Juan M. Corchado Juan F. De Paz Miguel P. Rocha Florentino Fernández Riverola Organization
Publisher: Springer Science & Business Media
ISBN: 354085861X
Category : Technology & Engineering
Languages : en
Pages : 265
Book Description
The success of Bioinformatics in recent years has been prompted by research in mole- lar biology and medicine in initiatives like the human genome project. The volume and diversification of data has increased so much that it is very hard if not impossible to analyze it by human experts. The analysis of this growing body of data, intensified by the development of a number of high-throughput experimental techniques that are generating the so called 'omics' data, has prompted for new computational methods. New global approaches, such as Systems Biology, have been emerging replacing the reductionist view that dominated biology research in the last decades, requiring the coordinated efforts of biological researchers with those related to data analysis, mathematical modelling and computer science. Computational methods have been helping in tasks related to knowledge discovery, modelling and optimization tasks. This workshop brings the opportunity to discuss applications of Bioinformatics and Computational Biology exploring the interactions between computer scientists, bio- gists and other scientific researchers. The IWPACBB technical program includes 29 papers (23 long papers and 6 short papers) selected from a submission pool of 51 papers, from 9 different countries. We thank the excellent work of the local organization members and also from the members of the Program Committee for their excellent reviewing work. October 2008 Juan M. Corchado Juan F. De Paz Miguel P. Rocha Florentino Fernández Riverola Organization
Optimal Control in Bioprocesses
Author: Jérôme Harmand
Publisher: John Wiley & Sons
ISBN: 1119597374
Category : Science
Languages : en
Pages : 264
Book Description
Optimal control is a branch of applied mathematics that engineers need in order to optimize the operation of systems and production processes. Its application to concrete examples is often considered to be difficult because it requires a large investment to master its subtleties. The purpose of Optimal Control in Bioprocesses is to provide a pedagogical perspective on the foundations of the theory and to support the reader in its application, first by using academic examples and then by using concrete examples in biotechnology. The book is thus divided into two parts, the first of which outlines the essential definitions and concepts necessary for the understanding of Pontryagin’s maximum principle – or PMP – while the second exposes applications specific to the world of bioprocesses. This book is unique in that it focuses on the arguments and geometric interpretations of the trajectories provided by the application of PMP.
Publisher: John Wiley & Sons
ISBN: 1119597374
Category : Science
Languages : en
Pages : 264
Book Description
Optimal control is a branch of applied mathematics that engineers need in order to optimize the operation of systems and production processes. Its application to concrete examples is often considered to be difficult because it requires a large investment to master its subtleties. The purpose of Optimal Control in Bioprocesses is to provide a pedagogical perspective on the foundations of the theory and to support the reader in its application, first by using academic examples and then by using concrete examples in biotechnology. The book is thus divided into two parts, the first of which outlines the essential definitions and concepts necessary for the understanding of Pontryagin’s maximum principle – or PMP – while the second exposes applications specific to the world of bioprocesses. This book is unique in that it focuses on the arguments and geometric interpretations of the trajectories provided by the application of PMP.
A Unified Computational Approach to Optimal Control Problems
Author: K. L. Teo
Publisher:
ISBN:
Category : Mathematics
Languages : en
Pages : 360
Book Description
Concerned with optimal control theory, this text aims to supplement existing work in this field from the viewpoints of computation and applications. In particular those computational algorithms derived from the concept of control parametrization are emphasized in this text.
Publisher:
ISBN:
Category : Mathematics
Languages : en
Pages : 360
Book Description
Concerned with optimal control theory, this text aims to supplement existing work in this field from the viewpoints of computation and applications. In particular those computational algorithms derived from the concept of control parametrization are emphasized in this text.
Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing
Author: Ganapathy Subramanian
Publisher: John Wiley & Sons
ISBN: 3527347690
Category : Technology & Engineering
Languages : en
Pages : 404
Book Description
Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing Explore new trends in continuous biomanufacturing with contributions from leading practitioners in the field With the increasingly widespread acceptance and investment in the ??technology, the last decade has demonstrated the utility of continuous ??processing in the pharmaceutical industry. In Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing, distinguished biotechnologist Dr. Ganapathy Subramanian delivers a comprehensive exploration of the potential of the continuous processing of biological products and discussions of future directions in advancing continuous processing to meet new challenges and demands in the manufacture of therapeutic products. A stand-alone follow-up to the editor’s Continuous Biomanufacturing: Innovative Technologies and Methods published in 2017, this new edited volume focuses on critical aspects of process intensification, process control, and the digital transformation of biopharmaceutical processes. In addition to topics like the use of multivariant data analysis, regulatory concerns, and automation processes, the book also includes: Thorough introductions to capacitance sensors to control feeding strategies and the continuous production of viral vaccines Comprehensive explorations of strategies for the continuous upstream processing of induced microbial systems Practical discussions of preparative hydrophobic interaction chromatography and the design of modern protein-A-resins for continuous biomanufacturing In-depth examinations of bioprocess intensification approaches and the benefits of single use for process intensification Perfect for biotechnologists, bioengineers, pharmaceutical engineers, and process engineers, Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing is also an indispensable resource for chemical engineers seeking a one-stop reference on continuous biomanufacturing.
Publisher: John Wiley & Sons
ISBN: 3527347690
Category : Technology & Engineering
Languages : en
Pages : 404
Book Description
Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing Explore new trends in continuous biomanufacturing with contributions from leading practitioners in the field With the increasingly widespread acceptance and investment in the ??technology, the last decade has demonstrated the utility of continuous ??processing in the pharmaceutical industry. In Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing, distinguished biotechnologist Dr. Ganapathy Subramanian delivers a comprehensive exploration of the potential of the continuous processing of biological products and discussions of future directions in advancing continuous processing to meet new challenges and demands in the manufacture of therapeutic products. A stand-alone follow-up to the editor’s Continuous Biomanufacturing: Innovative Technologies and Methods published in 2017, this new edited volume focuses on critical aspects of process intensification, process control, and the digital transformation of biopharmaceutical processes. In addition to topics like the use of multivariant data analysis, regulatory concerns, and automation processes, the book also includes: Thorough introductions to capacitance sensors to control feeding strategies and the continuous production of viral vaccines Comprehensive explorations of strategies for the continuous upstream processing of induced microbial systems Practical discussions of preparative hydrophobic interaction chromatography and the design of modern protein-A-resins for continuous biomanufacturing In-depth examinations of bioprocess intensification approaches and the benefits of single use for process intensification Perfect for biotechnologists, bioengineers, pharmaceutical engineers, and process engineers, Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing is also an indispensable resource for chemical engineers seeking a one-stop reference on continuous biomanufacturing.
Optimization—Theory and Applications
Author: L. Cesari
Publisher: Springer Science & Business Media
ISBN: 1461381657
Category : Science
Languages : en
Pages : 555
Book Description
This book has grown out of lectures and courses in calculus of variations and optimization taught for many years at the University of Michigan to graduate students at various stages of their careers, and always to a mixed audience of students in mathematics and engineering. It attempts to present a balanced view of the subject, giving some emphasis to its connections with the classical theory and to a number of those problems of economics and engineering which have motivated so many of the present developments, as well as presenting aspects of the current theory, particularly value theory and existence theorems. However, the presentation ofthe theory is connected to and accompanied by many concrete problems of optimization, classical and modern, some more technical and some less so, some discussed in detail and some only sketched or proposed as exercises. No single part of the subject (such as the existence theorems, or the more traditional approach based on necessary conditions and on sufficient conditions, or the more recent one based on value function theory) can give a sufficient representation of the whole subject. This holds particularly for the existence theorems, some of which have been conceived to apply to certain large classes of problems of optimization. For all these reasons it is essential to present many examples (Chapters 3 and 6) before the existence theorems (Chapters 9 and 11-16), and to investigate these examples by means of the usual necessary conditions, sufficient conditions, and value function theory.
Publisher: Springer Science & Business Media
ISBN: 1461381657
Category : Science
Languages : en
Pages : 555
Book Description
This book has grown out of lectures and courses in calculus of variations and optimization taught for many years at the University of Michigan to graduate students at various stages of their careers, and always to a mixed audience of students in mathematics and engineering. It attempts to present a balanced view of the subject, giving some emphasis to its connections with the classical theory and to a number of those problems of economics and engineering which have motivated so many of the present developments, as well as presenting aspects of the current theory, particularly value theory and existence theorems. However, the presentation ofthe theory is connected to and accompanied by many concrete problems of optimization, classical and modern, some more technical and some less so, some discussed in detail and some only sketched or proposed as exercises. No single part of the subject (such as the existence theorems, or the more traditional approach based on necessary conditions and on sufficient conditions, or the more recent one based on value function theory) can give a sufficient representation of the whole subject. This holds particularly for the existence theorems, some of which have been conceived to apply to certain large classes of problems of optimization. For all these reasons it is essential to present many examples (Chapters 3 and 6) before the existence theorems (Chapters 9 and 11-16), and to investigate these examples by means of the usual necessary conditions, sufficient conditions, and value function theory.
Bioreaction Engineering Principles
Author: Jens Nielsen
Publisher: Springer
ISBN: 1461507677
Category : Technology & Engineering
Languages : en
Pages : 537
Book Description
This is the second edition of the text "Bioreaction Engineering Principles" by Jens Nielsen and John Villadsen, originally published in 1994 by Plenum Press (now part of Kluwer). Time runs fast in Biotechnology, and when Kluwer Plenum stopped reprinting the first edition and asked us to make a second, revised edition we happily accepted. A text on bioreactions written in the early 1990's will not reflect the enormous development of experimental as well as theoretical aspects of cellular reactions during the past decade. In the preface to the first edition we admitted to be newcomers in the field. One of us (JV) has had 10 more years of job training in biotechnology, and the younger author (IN) has now received international recognition for his work with the hottest topics of "modem" biotechnology. Furthermore we are happy to have induced Gunnar Liden, professor of chemical reaction engineering at our sister university in Lund, Sweden to join us as co-author of the second edition. His contribution, especially on the chemical engineering aspects of "real" bioreactors has been of the greatest value. Chapter 8 of the present edition is largely unchanged from the first edition. We wish to thank professor Martin Hjortso from LSU for his substantial help with this chapter.
Publisher: Springer
ISBN: 1461507677
Category : Technology & Engineering
Languages : en
Pages : 537
Book Description
This is the second edition of the text "Bioreaction Engineering Principles" by Jens Nielsen and John Villadsen, originally published in 1994 by Plenum Press (now part of Kluwer). Time runs fast in Biotechnology, and when Kluwer Plenum stopped reprinting the first edition and asked us to make a second, revised edition we happily accepted. A text on bioreactions written in the early 1990's will not reflect the enormous development of experimental as well as theoretical aspects of cellular reactions during the past decade. In the preface to the first edition we admitted to be newcomers in the field. One of us (JV) has had 10 more years of job training in biotechnology, and the younger author (IN) has now received international recognition for his work with the hottest topics of "modem" biotechnology. Furthermore we are happy to have induced Gunnar Liden, professor of chemical reaction engineering at our sister university in Lund, Sweden to join us as co-author of the second edition. His contribution, especially on the chemical engineering aspects of "real" bioreactors has been of the greatest value. Chapter 8 of the present edition is largely unchanged from the first edition. We wish to thank professor Martin Hjortso from LSU for his substantial help with this chapter.