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Author: Christine E. Engeland
Publisher: Humana
ISBN: 9781493997961
Category : Medical
Languages : en
Pages : 329
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Book Description
This book aims to provide a guide for virologists, translational researchers, and clinicians in the field of cancer research by providing reference protocols and methodologies from vector development through clinical translation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Oncolytic Viruses: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author: Christine E. Engeland
Publisher: Humana
ISBN: 9781493997961
Category : Medical
Languages : en
Pages : 329
Get Book Here
Book Description
This book aims to provide a guide for virologists, translational researchers, and clinicians in the field of cancer research by providing reference protocols and methodologies from vector development through clinical translation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Oncolytic Viruses: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author: Christine E. Engeland
Publisher: Humana
ISBN: 9781493997930
Category : Medical
Languages : en
Pages : 329
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Book Description
This book aims to provide a guide for virologists, translational researchers, and clinicians in the field of cancer research by providing reference protocols and methodologies from vector development through clinical translation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Oncolytic Viruses: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author: Natalia L. Komarova
Publisher: Springer Science & Business Media
ISBN: 1461483018
Category : Mathematics
Languages : en
Pages : 235
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Book Description
Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.
Author: Benjamin Gesundheit
Publisher: Frontiers Media SA
ISBN: 2889453588
Category :
Languages : en
Pages : 195
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Book Description
The ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. Understanding the mechanisms involved and the complex interaction between the viruses and the immune system will undoubtedly help guide the development of new strategies. Theranostic biomarkers to monitor these therapies in clinical trials serve an important need in this innovative field and demand further research.
Author: Dr. Hakim. K. Saboowala
Publisher: Dr.Hakim Saboowala
ISBN:
Category : Medical
Languages : en
Pages : 40
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Book Description
Understanding the “Oncolytic Virus (OV) Basis & Therapy.” Oncolytic viruses (OVs) are an emerging class of cancer therapeutics that offer the: · Benefits of selective replication in tumour cells, · Delivery of multiple eukaryotic transgene payloads, · Induction of immunogenic cell death and promotion of antitumour immunity, and · Tolerable safety profile that largely does not overlap with that of other cancer therapeutics. To date, four OVs and one non-oncolytic virus have been approved for the treatment of cancer globally although talimogene laherparepvec (T-VEC) remains the only widely approved therapy. Despite increasing research interest, a better understanding of the underlying biology of OVs is needed to enable the full therapeutic potential of these agents in patients with cancer. Thus, it is strived in this Booklet to precisely describe: ü Time-line History of oncolytic virus development, ü Mechanisms of Tumour Tropism, ü Mechanisms of action of virus destroying tumour cells and ü Inherent and engineered oncolytic viruses. Further, it is also attempted to describe on optimization of the use of OVs in clinical practice along with plenty of relevant IMAGES for better understanding. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Author: Shuren Zhang
Publisher: Springer
ISBN: 9401775559
Category : Medical
Languages : en
Pages : 293
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Book Description
This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors.
Author:
Publisher: Springer
ISBN: 9781617793417
Category :
Languages : en
Pages : 252
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Book Description
Author: Dr. Hakim Saboowala
Publisher: Dr.Hakim Saboowala
ISBN:
Category : Medical
Languages : en
Pages : 56
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Book Description
In recent years, there has been an explosion in the number of immune-oncology drugs approved or in development for cancer treatment, and some of these therapies have demonstrated objective responses not seen with small molecules Three oncolytic viruses (OVs): 1. an echovirus, 2. an adenovirus, and 3. a herpes simplex-1virus, have passed governmental regulatory approval in Latvia, China, and the USA and EU. Numerous other recombinant viruses from diverse families are in clinical testing in cancer patients and we highlight the design features of selected examples, including: · Adenovirus, · Herpes simplex virus, · Measles virus, · Retrovirus, · Reovirus, · Vaccinia virus, · Vesicular stomatitis virus. An attempt has been made in this Booklet to discuss current clinical advancements in oncolytic viral therapy, with a focus on the viral platforms approved for clinical use and highlights the benefits each platform provides. Further, thoughts have been provided on the path forward for this rapidly expanding field especially in combination with immune modulating drugs …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Author: Fouad Sabry
Publisher: One Billion Knowledgeable
ISBN:
Category : Medical
Languages : en
Pages : 288
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Book Description
What Is Oncolytic Virus A virus is said to be oncolytic if it targets cancer cells for infection and then proceeds to destroy those cells. As a result of the oncolysis, infected cancer cells are being eliminated, which results in the production of additional infectious virus particles called virions, which further contribute to the elimination of the residual tumor. It is believed that oncolytic viruses not only induce the direct killing of tumor cells, but also activate the host's anti-tumor immune system responses. [Citation needed] [Citation needed] In addition to this, oncolytic viruses are able to influence the microenvironment of the tumor in a variety of different ways. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Oncolytic virus Chapter 2: Virotherapy Chapter 3: Virus latency Chapter 4: Herpes simplex virus Chapter 5: Tony Minson Chapter 6: Genetically modified virus Chapter 7: Pelareorep Chapter 8: Pexastimogene devacirepvec Chapter 9: Herpes simplex research Chapter 10: Jennerex Chapter 11: Talimogene laherparepvec Chapter 12: Oncolytic herpes virus Chapter 13: Oncolytic adenovirus Chapter 14: GL-ONC1 Chapter 15: Genelux Corporation Chapter 16: ONCOS-102 Chapter 17: Akseli Hemminki Chapter 18: Infected cell protein 34.5 Chapter 19: Oncolytic AAV Chapter 20: HSV epigenetics Chapter 21: Transgene (company) (II) Answering the public top questions about oncolytic virus. (III) Real world examples for the usage of oncolytic virus in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of oncolytic virus' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of oncolytic virus.
Author: Philippe Fournier
Publisher: Frontiers Media SA
ISBN: 2889194507
Category : Cancer
Languages : en
Pages : 111
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Book Description
Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.
