On the Feasibility of Dose Quantification with in Beam PET Data in Radiotherapy with 12 C and Proton Beams PDF Download
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Author: Katia Parodi
Publisher:
ISBN:
Category :
Languages : en
Pages : 117
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Book Description
Author: Katia Parodi
Publisher:
ISBN:
Category :
Languages : en
Pages : 117
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Author: Vinzenz Brendler
Publisher:
ISBN:
Category : Ion bombardment
Languages : en
Pages : 117
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Book Description
Author: Matthias Würl
Publisher: Springer
ISBN: 3658131683
Category : Science
Languages : en
Pages : 99
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Book Description
Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.
Author: Joao Seco
Publisher: CRC Press
ISBN: 1000455564
Category : Medical
Languages : en
Pages : 299
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Book Description
Thoroughly updated throughout, this second edition of Monte Carlo Techniques in Radiation Therapy: Applications to Dosimetry, Imaging, and Preclinical Radiotherapy, edited by Joao Seco and Frank Verhaegen, explores the use of Monte Carlo methods for modelling various features of internal and external radiation sources. Monte Carlo methods have been heavily used in the field of radiation therapy in applications such as dosimetry, imaging, radiation chemistry, modelling of small animal irradiation units, etc. The aim of this book is to provide a compendium of the Monte Carlo methods that are commonly used in radiation therapy applications, which will allow students, postdoctoral fellows, and university professors to learn and teach Monte Carlo techniques. This book provides concise but detailed information about many Monte Carlo applications that cannot be found in any other didactic or scientific book. This second edition contains many new chapters on topics such as: Monte Carlo studies of prompt gamma emission Developments in proton imaging Monte Carlo for cone beam CT imaging Monte Carlo modelling of proton beams for small animal irradiation Monte Carlo studies of microbeam radiation therapy Monte Carlo in micro- and nano-dosimetry GPU-based fast Monte Carlo simulations for radiotherapy This book is primarily aimed at students and scientists wishing to learn and improve their knowledge of Monte Carlo methods in radiation therapy.
Author: Harald Paganetti
Publisher: CRC Press
ISBN: 1351855751
Category : Science
Languages : en
Pages : 772
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Book Description
Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective
Author: Marco Durante
Publisher: Frontiers Media SA
ISBN: 288945391X
Category :
Languages : en
Pages : 650
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Book Description
High-energy charged particles represent a cutting-edge technique in radiation oncology. Protons and carbon ions are used in several centers all over the world for the treatment of different solid tumors. Typical indications are ocular malignancies, tumors of the base of the skull, hepatocellular carcinomas and various sarcomas. The physical characteristics of the charged particles (Bragg peak) allow sparing of much more normal tissues than it is possible using conventional X-rays, and for this reason all pediatric tumors are considered eligible for protontherapy. Ions heavier than protons also display special radiobiological characteristics, which make them effective against radioresistant and hypoxic tumors. On the other hand, protons and ions with high charge (Z) and energy (HZE particles) represent a major risk for human space exploration. The main late effect of radiation exposure is cancer induction, and at the moment the dose limits for astronauts are based on cancer mortality risk. The Mars Science Laboratory (MSL) measured the dose on the route to Mars and on the planet’s surface, suggesting that a human exploration missions will exceed the radiation risk limits. Notwithstanding many studies on carcinogenesis induced by protons and heavy ions, the risk uncertainty remains very high. In this research topic we aim at gathering the experiences and opinions of scientists dealing with high-energy charged particles either for cancer treatment or for space radiation protection. Clinical results with protons and heavy ions, as well as research in medical physics and pre-clinical radiobiology are reported. In addition, ground-based and spaceflight studies on the effects of space radiation are included in this book. Particularly relevant for space studies are the clinical results on normal tissue complications and second cancers. The eBook nicely demonstrates that particle therapy in oncology and protection of astronauts from space radiation share many common topics, and can learn from each other.
Author: Harald Paganetti
Publisher: CRC Press
ISBN: 1439836450
Category : Medical
Languages : en
Pages : 691
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Book Description
Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.
Author: Arash Darafsheh
Publisher: CRC Press
ISBN: 1351005367
Category : Medical
Languages : en
Pages : 816
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Book Description
This comprehensive book covers the everyday use and underlying principles of radiation dosimeters used in radiation oncology clinics. It provides an up-to-date reference spanning the full range of current modalities with emphasis on practical know-how. The main audience is medical physicists, radiation oncology physics residents, and medical physics graduate students. The reader gains the necessary tools for determining which detector is best for a given application. Dosimetry of cutting edge techniques from radiosurgery to MRI-guided systems to small fields and proton therapy are all addressed. Main topics include fundamentals of radiation dosimeters, brachytherapy and external beam radiation therapy dosimetry, and dosimetry of imaging modalities. Comprised of 30 chapters authored by leading experts in the medical physics community, the book: Covers the basic principles and practical use of radiation dosimeters in radiation oncology clinics across the full range of current modalities. Focuses on providing practical guidance for those using these detectors in the clinic. Explains which detector is more suitable for a particular application. Discusses the state of the art in radiotherapy approaches, from radiosurgery and MR-guided systems to advanced range verification techniques in proton therapy. Gives critical comparisons of dosimeters for photon, electron, and proton therapies.
Author: Sultan B. Dabagov
Publisher:
ISBN: 9780819467782
Category : Science
Languages : en
Pages : 582
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Book Description
Proceedings of SPIE present the original research papers presented at SPIE conferences and other high-quality conferences in the broad-ranging fields of optics and photonics. These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.
Author:
Publisher:
ISBN:
Category : Imaging systems in medicine
Languages : en
Pages : 758
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Book Description
