On the Cancer Frontier

On the Cancer Frontier PDF Author: Paul Marks
Publisher: PublicAffairs
ISBN: 1610392531
Category : Medical
Languages : en
Pages : 274

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Book Description
In 1950, a diagnosis of cancer was all but a death sentence. Mortality rates only got worse, and as late as 1986, an article in the New England Journal of Medicine lamented: "We are losing the war against cancer." Cancer is one of humankind's oldest and most persistent enemies; it has been called the existential disease. But we are now entering a new, and more positive, phase in this long campaign. While cancer has not been cured -- and a cure may elude us for a long time yet -- there has been a revolution in our understanding of its nature. Years of brilliant science have revealed how this individualistic disease seizes control of the foundations of life -- our genes -- and produces guerrilla cells that can attack and elude treatments. Armed with those insights, scientists have been developing more effective weapons and producing better outcomes for patients. Paul A. Marks, MD, has been a leader in these efforts to finally control this devastating disease. Marks helped establish the strategy for the "war on cancer" in 1971 as a researcher and member of President Nixon's cancer panel. As the president and chief executive officer for nineteen years at the world's pre-eminent cancer hospital, the Memorial Sloan-Kettering Cancer Center, he was instrumental in ending the years of futility. He also developed better therapies that promise a new era of cancer containment. Some cancers, like childhood leukemia and non-Hodgkin's lymphoma, that were once deadly conditions, are now survivable -- even curable. New steps in prevention and early diagnosis are giving patients even more hope. On the Cancer Frontier is Marks' account of the transformation in our understanding of cancer and why there is growing optimism in our ability to stop it.

On the Cancer Frontier

On the Cancer Frontier PDF Author: Paul Marks
Publisher: PublicAffairs
ISBN: 1610392531
Category : Medical
Languages : en
Pages : 274

Get Book Here

Book Description
In 1950, a diagnosis of cancer was all but a death sentence. Mortality rates only got worse, and as late as 1986, an article in the New England Journal of Medicine lamented: "We are losing the war against cancer." Cancer is one of humankind's oldest and most persistent enemies; it has been called the existential disease. But we are now entering a new, and more positive, phase in this long campaign. While cancer has not been cured -- and a cure may elude us for a long time yet -- there has been a revolution in our understanding of its nature. Years of brilliant science have revealed how this individualistic disease seizes control of the foundations of life -- our genes -- and produces guerrilla cells that can attack and elude treatments. Armed with those insights, scientists have been developing more effective weapons and producing better outcomes for patients. Paul A. Marks, MD, has been a leader in these efforts to finally control this devastating disease. Marks helped establish the strategy for the "war on cancer" in 1971 as a researcher and member of President Nixon's cancer panel. As the president and chief executive officer for nineteen years at the world's pre-eminent cancer hospital, the Memorial Sloan-Kettering Cancer Center, he was instrumental in ending the years of futility. He also developed better therapies that promise a new era of cancer containment. Some cancers, like childhood leukemia and non-Hodgkin's lymphoma, that were once deadly conditions, are now survivable -- even curable. New steps in prevention and early diagnosis are giving patients even more hope. On the Cancer Frontier is Marks' account of the transformation in our understanding of cancer and why there is growing optimism in our ability to stop it.

Cancer and the Kidney

Cancer and the Kidney PDF Author: Eric P. Cohen
Publisher: Oxford University Press, USA
ISBN: 0199580197
Category : Medical
Languages : en
Pages : 382

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Book Description
Cancer and the Kidney covers the challenging overlap area of nephrology and oncology, both in terms of kidney problems in cancer patients, and cancer that affects kidney patients, including assessment of kidney function, to paraneoplastic disorders, acquired cysts and native kidney cancers, and all points inbetween.

Frontiers in Oncology: Quarterly Highlights. Quarter 1 2019

Frontiers in Oncology: Quarterly Highlights. Quarter 1 2019 PDF Author: Giuseppe Giaccone
Publisher: Frontiers Media SA
ISBN: 288945939X
Category :
Languages : en
Pages : 213

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Book Description
Foreword from the Field Chief Editor, Giuseppe Giaccone Once again Frontiers in Oncology has started the year on a positive note, breaking previous records for submissions and publications, as well as the number of Research Topic article collections posted. The journal continues to grow in size, adding an 18th section focusing on Cancer Metabolism, led by Michael Lisanti and Ubaldo Martinez-Outschoorn, and has brought on a total of five new Chief Editors. Here, introducing Frontiers in Oncology: Quarterly Highlights, we feature a collection of carefully selected articles published during the first quarter of 2019 across the different sections. With a record number of papers to choose from, the papers enclosed in this Special Edition highlight some of the recent advances across the different disciplines. With an array of papers looking at everything from translational research to association studies and clinical trial results, Frontiers in Oncology continues to publish high-quality research from researchers around the world. Many of the recently posted Research Topics in the journal focus on early diagnosis and prevention, as well as the importance of survivorship studies and outcomes of cancer treatment. Consideration of such aspects of cancer research and treatment is pivotal in the global effort towards increased survival rates and improved quality of life. With ASCO 2019 marking the end of Q1 and the transition into Q2, the journal looks forward to the rest of the year, and continuing to play an active role in the research community. Giuseppe Giaccone

The Cancer Chronicles

The Cancer Chronicles PDF Author: George Johnson
Publisher: Vintage
ISBN: 0385349718
Category : Medical
Languages : en
Pages : 305

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Book Description
When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

The Five Health Frontiers

The Five Health Frontiers PDF Author: Christopher Thomas
Publisher:
ISBN: 9780745343921
Category :
Languages : en
Pages : 240

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Book Description
A transformative approach to public health, political economy and social care in the wake of Covid-19

Re-Irradiation: New Frontiers

Re-Irradiation: New Frontiers PDF Author: Carsten Nieder
Publisher: Springer
ISBN: 3319418254
Category : Medical
Languages : en
Pages : 368

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Book Description
This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.

Science, the Endless Frontier

Science, the Endless Frontier PDF Author: Vannevar Bush
Publisher: Princeton University Press
ISBN: 069120165X
Category : Science
Languages : en
Pages : 186

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Book Description
The classic case for why government must support science—with a new essay by physicist and former congressman Rush Holt on what democracy needs from science today Science, the Endless Frontier is recognized as the landmark argument for the essential role of science in society and government’s responsibility to support scientific endeavors. First issued when Vannevar Bush was the director of the US Office of Scientific Research and Development during the Second World War, this classic remains vital in making the case that scientific progress is necessary to a nation’s health, security, and prosperity. Bush’s vision set the course for US science policy for more than half a century, building the world’s most productive scientific enterprise. Today, amid a changing funding landscape and challenges to science’s very credibility, Science, the Endless Frontier resonates as a powerful reminder that scientific progress and public well-being alike depend on the successful symbiosis between science and government. This timely new edition presents this iconic text alongside a new companion essay from scientist and former congressman Rush Holt, who offers a brief introduction and consideration of what society needs most from science now. Reflecting on the report’s legacy and relevance along with its limitations, Holt contends that the public’s ability to cope with today’s issues—such as public health, the changing climate and environment, and challenging technologies in modern society—requires a more capacious understanding of what science can contribute. Holt considers how scientists should think of their obligation to society and what the public should demand from science, and he calls for a renewed understanding of science’s value for democracy and society at large. A touchstone for concerned citizens, scientists, and policymakers, Science, the Endless Frontier endures as a passionate articulation of the power and potential of science.

Invisible Frontiers

Invisible Frontiers PDF Author: Stephen S. Hall
Publisher: Oxford University Press, USA
ISBN: 9780195151596
Category : Medical
Languages : en
Pages : 0

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Book Description
Author Stephen Hall weaves together the scientific, social and political threads of this story - the fierce rivalry between labs, the fateful clash of egos within labs, the invasion of academia by commerce, the public fears about genetic engineering, the threat of government regulation, and the ultimate triumph of modern biology - to give us an outstanding tale of scientific research."--BOOK JACKET.

Cancer Metastasis

Cancer Metastasis PDF Author: David Lyden
Publisher: Cambridge University Press
ISBN: 1139498754
Category : Science
Languages : en
Pages : 661

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Book Description
Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.

Science at the Frontier

Science at the Frontier PDF Author: National Academy of Sciences
Publisher: National Academies Press
ISBN: 0309045924
Category : Science
Languages : en
Pages : 286

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Book Description
Science at the Frontier takes you on a journey through the minds of some of the nation's leading young scientists as they explore the most exciting areas of discovery today. Based on the second Frontiers of Science symposium sponsored by the National Academy of Sciences, this book describes recent accomplishments and new directions in ten basic fields, represented by outstanding scientists convening to discuss their research. It captures the excitement and personal quality of these exchanges, sometimes pointing to surprising connections spanning the boundaries of traditional disciplines, while providing a context for the reader that explains the basic scientific framework for the fields under discussion. The volume explores: New modifications to scientific theory as geologists probe deep inside the earth and astrophysicists reach to the limits of the observable universe for answers to some of nature's most fundamental and vexing questions. The influence of research in smog formation on the public debate about how to effectively control air pollution. The increasing use of computer modeling in science, from describing the evolution of cellular automata to revealing the workings of the human brain via neural networks. The rise of dynamical systems (the study of chaotic behavior in nature) to a full-fledged science. The search to understand the regulation of gene activity and the many biological problems-such as the onset of cancer-to which it applies. Recent progress in the quest to transform what we know about photosynthesis into functional, efficient systems to tap the sun's energy. Current developments in magnetic resonance imaging and its promise for new breakthroughs in medical diagnosis. Throughout this work the reader is witness to scientific discovery and debate centered on such common concerns as the dramatic and transforming effect of computers on scientists' thinking and research; the development of more cross-disciplinary perspectives; and the very nature of the scientific enterprise itself-what it is to be part of it, and its significance for society. Science at the Frontier is must reading for informed lay readers, scientists interested in fields other than their own, and science students considering a future specialization.