OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 495: Ros (Reactive Oxygen Species) Assay for Photoreactivity PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264567119
Category :
Languages : en
Pages : 18
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Book Description
Phototoxicity is defined as a toxic response is elicited by topically or systemically administered photoreactive chemicals after the exposure of the body to environmental light. Several classes of photoreactive chemicals could cause phototoxic reactions when activated by light at otherwise non-toxic doses. Phototoxicity can be categorized as photoirritation, photoallergy, and photogenotoxicity. The purpose of this test is to measure the phototoxicity of a chemical. The main event in any phototoxic reaction is the absorption of photons of a wavelength that induces the excitation of the chromophore. Excitation energy is often transferred to oxygen molecules, followed by the generation of ROS (reactive Oxygen Species). Measurements are performed using a spectrometer. The determination of the ROS generation from irradiated chemicals with simulated sunlight is indicative of phototoxic potential.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264567119
Category :
Languages : en
Pages : 18
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Book Description
Phototoxicity is defined as a toxic response is elicited by topically or systemically administered photoreactive chemicals after the exposure of the body to environmental light. Several classes of photoreactive chemicals could cause phototoxic reactions when activated by light at otherwise non-toxic doses. Phototoxicity can be categorized as photoirritation, photoallergy, and photogenotoxicity. The purpose of this test is to measure the phototoxicity of a chemical. The main event in any phototoxic reaction is the absorption of photons of a wavelength that induces the excitation of the chromophore. Excitation energy is often transferred to oxygen molecules, followed by the generation of ROS (reactive Oxygen Species). Measurements are performed using a spectrometer. The determination of the ROS generation from irradiated chemicals with simulated sunlight is indicative of phototoxic potential.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264353089
Category :
Languages : en
Pages : 28
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Book Description
Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.
Author: Monika Schäfer-Korting
Publisher: Springer Nature
ISBN: 3030700631
Category : Medical
Languages : en
Pages : 325
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Book Description
This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
Author: Ali S. Faqi
Publisher: Elsevier
ISBN: 0323984622
Category : Medical
Languages : en
Pages : 1074
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Book Description
A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. - Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy - Includes the latest international guidelines for nonclinical toxicology in both small and large molecules - Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology
Author: M.H. Fulekar
Publisher: Springer Science & Business Media
ISBN: 8132211669
Category : Science
Languages : en
Pages : 204
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Book Description
Global society in the 21st century is facing challenges of improving the quality of air, water, soil and the environment and maintaining the ecological balance. Environmental pollution, thus, has become a major global concern. The modern growth of industrialization, urbanization, modern agricultural development and energy generation has resulted in the indiscriminate exploitation of natural resources for fulfilling human desires and needs, which has contributed in disturbing the ecological balance on which the quality of our environment depends. Human beings, in the truest sense, are the product of their environment. The man-environment relationship indicates that pollution and deterioration of the environment have a social origin. The modern technological advancements in chemical processes/operations have generated new products, resulting in new pollutants in such abundant levels that they are above the self-cleaning capacity of the environment. One of the major issues in recent times is the threat tohuman lives due to the progressive deterioration of the environment from various sources. The impact of the pollutants on the environment will be significant when the accumulated pollutants load will exceed the carrying capacity of the receiving environment. Sustainable development envisages the use of natural resources, such as forests, land, water and fisheries, in a sustainable manner without causing changes in our natural world. The Rio de Janeiro-Earth Summit, held in Brazil in 1992, focused on sustainable development to encourage respect and concern for the use of natural resources in a sustainable manner for the protection of the environment. This book will be beneficial as a source of educational material to post-graduate research scholars, teachers and industrial personnel for maintaining the balance in the use of natural sources for sustainable development.
Author: Fernando López-Valdez
Publisher: Springer
ISBN: 3319967193
Category : Technology & Engineering
Languages : en
Pages : 221
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Book Description
Nanobiotechnology in agriculture is a new knowledge area that offers novel possibilities to achieve high productivity levels at manageable costs during the production and merchandising of crops. This book shows us how we can use the cutting-edge knowledge about agriculture, nanotechnology, and biotechnology to increase the agricultural productivity and shape a sustainable future in order to increase the social welfare in rural areas and preserve the environmental health. Specialists from several countries will provide their feedback on a range of relevant topics such as environment-friendly use of nanofertilisers, nanodevices, nano-food packaging, nanocoating and nanocarriers and their relationship with the modern agriculture.
Author: Ruy Beck
Publisher: Springer Science & Business Media
ISBN: 3642197922
Category : Technology & Engineering
Languages : en
Pages : 368
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Book Description
The book "Nanocosmetics and nanomedicines: new approaches for skin care” contains a summary of the most important nanocarriers for skin delivery. Although “nanocosmetics” is a subject widely commented in the academy and the beauty industry, a book covering the skin care treatments using nanotechnological approaches with cosmetics and nanomedicines is still missing, therefore the need for this publication. This book is divided in three parts: The first one (Part A) is devoted to a brief review on the main topics related to the skin delivery and to the introduction of the subject “nanocosmetics”. The second part (Part B) presents different types of nanocarriers applied as skin delivery systems for cosmetics or drugs. The last part (Part C) shows a wide range of applications of nanotechnology on the skin care area as well as on dermatocosmetic and dermatological fields.
Author: Ajit Varma
Publisher: Springer
ISBN: 3319491970
Category : Science
Languages : en
Pages : 459
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Book Description
This book provides essential molecular techniques and protocols for analyzing microbes that are useful for developing novel bio-chemicals, such as medicines, biofuels, and plant protection substances. The topics and techniques covered include: microbial diversity and composition; microorganisms in the food industry; mass cultivation of sebacinales; host-microbe interaction; targeted gene disruption; function-based metagenomics to reveal the rhizosphere microbiome; mycotoxin biosynthetic pathways; legume-rhizobium symbioses; multidrug transporters of yeast; drug-resistant bacteria; the fungal endophyte piriformospora indica; medicinal plants; arbuscular mycorrhizal fungi; biosurfactants in microbial enhanced oil recovery; and biocontrol of the soybean cyst nematode with root endophytic fungi; as well as microbe-mediated drought tolerance in plants.
Author: Charis M. Galanakis
Publisher: Woodhead Publishing
ISBN: 0128135735
Category : Technology & Engineering
Languages : en
Pages : 458
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Book Description
Polyphenols: Properties, Recovery, and Applications covers polyphenol properties, health effects and new trends in recovery procedures and applications. Beginning with coverage of the metabolism and health effects of polyphenols, the book then addresses recovery, analysis, processing issues and industrial applications. The book not only connects the properties and health effects of polyphenols with recovery, processing and encapsulation issues, but also explores industrial applications that are affected by these aspects, including both current applications and those under development. - Covers the properties and health effects of polyphenols, along with trends in recovery procedures and applications - Addresses recovery, analysis and processing issues - Concludes with coverage of the industrial applications of polyphenols
Author: Nandita Dasgupta
Publisher: Springer
ISBN: 9811069867
Category : Science
Languages : en
Pages : 196
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Book Description
This book provides authentic and comprehensive information on the concepts, methods, functional details and applications of nano-emulsions. Following an introduction to the applications of nanotechnology in the development of foods, it elaborates on food-grade nano-emulsion and their significance, discusses various techniques and methods for producing food-grade nano-emulsion, and reviews the main ingredient and component of food-grade nano-emulsions. Further, the book includes a critical review of the engineering aspect of fabricating food-grade nano-emulsions and describe recently developed vitamin encapsulated nano-systems. In closing, it discuss the challenges and opportunities of characterizing nano-emulsified systems, the market risks and opportunities of nano-emulsified foods, and packaging techniques and safety issues – including risk identification and risk management – for nano-foods. The book offers a unique guide for scientists and researchers working in this field. It will also help researchers, policymakers, industry personnel, journalists and the general public to understand food nanotechnology in great detail.
