OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264071342
Category :
Languages : en
Pages : 6
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Book Description
Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071342
Category :
Languages : en
Pages : 6
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Book Description
Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264264825
Category :
Languages : en
Pages : 15
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Book Description
The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071504
Category :
Languages : en
Pages : 6
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Book Description
The mouse heritable translocation test detects structural and numerical chromosome changes in mammalian germ cells as recovered in first generation progeny. The types of chromosome changes detected in this test system are reciprocal translocations ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071423
Category :
Languages : en
Pages : 6
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Book Description
This assay may be used to measure mitotic recombination (gene conversion or crossingover) in yeast, a eukaryotic micro-organism. Crossing-over is generally assayed by the production of recessive homozygous colonies or sectors produced in a ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071482
Category :
Languages : en
Pages : 4
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Book Description
The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071407
Category :
Languages : en
Pages : 5
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Book Description
This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071369
Category :
Languages : en
Pages : 6
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Book Description
Dominant lethal (DL) effects cause embryonic or foetal death. Induction of a dominant lethal event after exposure to a test substance (liquid, solid, vapour or gas, ...) indicates that the substance has affected germinal tissue of the test species ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071385
Category :
Languages : en
Pages : 5
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Book Description
The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070842
Category :
Languages : en
Pages : 8
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Book Description
This Test Guideline for reproduction testing is designed to provide general information concerning the effects of a test substance (Solid, liquid, gas or vapour) on male and female reproductive performance. The test substance is administered orally ...
